Inflammatory profile in optimally treated patients with adult versus early-onset asthma

Papaporfyriou, Anastasia; Papaioannou, Andriana Ι.; Hillas, Geogrios; Konstantelou, Elissavet; Tseliou, Eleni; Koulouris, Nikolaos; Papiris, Spyros; Bakakos, Petros; Κostikas, Κonstantinos; Loukides, Stelios

doi:10.1080/00325481.2019.1600884

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…Reducing the expression of IL-6 can reduce the inflammation level of asthma lung tissue and improve lung function (15). IL-8 strongly attracts neutrophils to the inflammatory site, and IL-8 in the serum and BALF of asthma patients was significantly increased (16). IL-17 has proinflammatory factors secreted by Th17 cells, is significantly increased in asthma and other inflammatory diseases, and is significantly correlated with the severity of the disease (17).…”

Section: Roc Curves Of Low Feno and High Feno In Balfmentioning

confidence: 99%

Correlation study of cytokine levels in alveolar lavage fluid with exhaled nitric oxide and lung function in children with bronchial asthma

Lü¹,

Ke²,

Cui³

et al. 2021

Transl Pediatr

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Background: The associations between cytokines in the bronchoalveolar lavage fluid (BALF), lung cytokine expression, fractional exhaled nitric oxide (FeNO) and pulmonary function test results in pediatric asthmatics have not been extensively characterized. This study sought to explore correlations between cytokines BALF, FeNO, and pulmonary function test results. Methods: From October 2018 to October 2020, a prospective study was conducted on 42 children with asthma and 17 children with pulmonary foreign bodies that required bronchoscopy. Pulmonary function tests and FeNO tests were performed on all patients. Patients were divided into a high FeNO group or low FeNO group based on their FeNO results. Interleukin (IL)-4, IL-5, IL-6, IL-8, IL-13, and IL-17 in the BALF were measured by enzyme-linked immunosorbent assays. Pearson correlations were used to assess the correlations between the cytokines in BALF, the pulmonary function test results, and the FeNO results. Pearson correlation was used to calculate the correlation coefficient "r" among alveolar lavage fluid cytokines, lung function, and FeNO. Receiver operating characteristic (ROC) curves were used to determine the area under the curve (AUC), sensitivity, and specificity of BALF cytokines for the high and low FeNO groups.

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Section: Roc Curves Of Low Feno and High Feno In Balfmentioning

confidence: 99%

Correlation study of cytokine levels in alveolar lavage fluid with exhaled nitric oxide and lung function in children with bronchial asthma

Lü¹,

Ke²,

Cui³

et al. 2021

Transl Pediatr

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show abstract

“…Asthma severity has been defined previously in different contexts to include lung function and the risk of acute exacerbations [3][4][5], but it may also be indicated by the minimum treatment required to achieve control at a specific time [1,[6][7][8][9]. This approach has been recommended by the joint American Thoracic Society/European Respiratory Society Taskforce [10].…”

Section: Introductionmentioning

confidence: 99%

Derivation of asthma severity from electronic prescription records using British thoracic society treatment steps

2022

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Background: Asthma severity is typically assessed through a retrospective assessment of the treatment required to control symptoms and to prevent exacerbations. The joint British Thoracic Society and Scottish Intercollegiate Guidelines Network (BTS/SIGN) guidelines encourage a stepwise approach to pharmacotherapy, and as such, current treatment step can be considered as a severity categorisation proxy. Briefly, the steps for adults can be summarised as: no controller therapy (Step 0), low-strength Inhaled Corticosteroids (ICS; Step 1), ICS plus Long-Acting Beta-2 Agonist (LABA; Step 2), medium-dose ICS + LABA (Step 3), and finally either an increase in strength or additional therapies (Step 4). This study aimed to investigate how BTS/SIGN Steps can be estimated from across a large cohort using electronic prescription records, and to describe the incidence of each BTS/SIGN Step in a general population. Methods: There were 41,433,707 prescriptions, for 671,304 individuals, in the Asthma Learning Health System Scottish cohort, between 1/2009 and 3/2017. Days on which an individual had a prescription for at least one asthma controller (preventer) medication were labelled prescription events. A rule-based algorithm was developed for extracting the strength and volume of medication instructed to be taken daily from free-text data fields. Asthma treatment regimens were categorised by the combination of medications prescribed in the 120 days preceding any prescription event and categorised into BTS/SIGN treatment steps. Results: Almost 4.5 million ALHS prescriptions were for asthma controllers. 26% of prescription events had no inhaled corticosteroid prescriptions in the preceding 120 days (Step 0), 16% were assigned to BTS/SIGN Step 1, 7% to Step 2, 21% to Step 3, and 30% to Step 4. The median days spent on a treatment step before a step-down in treatment was 297 days, whereas a step-up only took a median of 134 days. Conclusion We developed a reproducible methodology enabling researchers to estimate BTS/SIGN asthma treatment steps in population health studies, providing valuable insights into population and patient-specific trajectories, towards improving the management of asthma.

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“…The measure of FeNO quanti es NO, and has been proposed as a marker of airway in ammation and as a guide for anti-in ammatory therapy in asthma [1,2,3]. According to an o cial ATS clinical practice guideline [4], a FeNO value of >50 ppb in adults and the elderly indicates severe asthma; however, asthma treatment strategies for severe asthma have poor e cacy and are high risk [5,6]. Several studies investigating the pathogenic mechanisms underlying severe asthma have been conducted in an effort to improve the therapeutic effect of treatment strategies [7,8,9].…”

Section: Introductionmentioning

confidence: 99%

Effects of PM2.5 and temperature on the incidence of severe asthma in adults and the elderly in Shanghai, China: A retrospective study

Ding

Gao

Zhang

et al. 2022

Preprint

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Background The study aimed to investigate the correlation between both particulate matter (PM) 2.5 and temperature and the incidence of severe asthma as diagnosed by fractional exhaled nitric oxide (FeNO) values of >50 parts per billion. Methods This large-scale retrospective study used data on PM2.5 and temperature from the Shanghai Meteorological Bureau in China that had been collected between May 2014 and April 2016. All patients with suspected airway inflammation, who had visited the Minhang branch of Zhongshan Hospital, an affiliation of Fudan University, between May 2014 and April 2016, were retrospectively enrolled in this study. Spearman’s rank correlation coefficient and multiple linear regression models were used to analyze the synergistic effect of PM2.5 and temperature on the incidence of severe asthma in the different subgroups of patients with suspected airway inflammation. Results PM2.5 and temperature were significantly correlated with the incidence of asthma in the Oldabove50 subgroup (Spearman’s r = 0.580, p = 0 .003 and Spearman’s r = -0.689, p ≤ 0.001, respectively), when analyzed using non-parametric statistical analysis methods. The combined effect of PM2.5 and temperature on the incidence of asthma was significantly greater in the Oldabove50 subgroup (R = 0.693) than in the Adultabove50 subgroup (R = 0.275) (F > Fα; Fα = 2.997066, p < 0.05). In particular, in the Oldabove50 subgroup, the effect of temperature on the incidence of asthma was greater than that of PM2.5, when using beta coefficients (p = 0.004). Conclusions The FeNO cut-off value can be used to determine the effect of PM2.5 and temperature on patients’ respiratory health. Although the study’s limitations may have impacted these findings, and further investigation is necessary, this study provided a convenient investigation into the epidemiology of asthma. Such research is important for public health.

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Inflammatory profile in optimally treated patients with adult versus early-onset asthma

Cited by 3 publications

References 19 publications

Correlation study of cytokine levels in alveolar lavage fluid with exhaled nitric oxide and lung function in children with bronchial asthma

Correlation study of cytokine levels in alveolar lavage fluid with exhaled nitric oxide and lung function in children with bronchial asthma

Derivation of asthma severity from electronic prescription records using British thoracic society treatment steps

Effects of PM2.5 and temperature on the incidence of severe asthma in adults and the elderly in Shanghai, China: A retrospective study

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