Inflammatory optic neuropathy following SARS-CoV-2 mRNA vaccine: Description of two cases

Barone, Valentina; Camilli, Federico; Crisci, Michela; Scandellari, Cinzia; Barboni, Piero

doi:10.1016/j.jns.2021.118186

Cited by 6 publications

(3 citation statements)

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“…Elevated levels of Ang II is a causal factor in neurodegeneration of the optic nerve, causing optic neuritis, which can result in severe irreversible visual loss ( Guo et al, 2017 ). Multiple case reports have described cases of optic neuropathy appearing shortly after mRNA vaccination for COVID-19 ( Maleki, 2021 ; Barone et al, 2021 ). Other debilitating neurological conditions are also appearing shortly after vaccination, where a causal relationship is suspected.…”

Section: Guillain Barré Syndrome and Neurologic Injury Syndromesmentioning

confidence: 99%

Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs

Seneff¹,

Nigh

Kyriakopoulos³

et al. 2022

Food and Chemical Toxicology

103

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Section: Guillain Barré Syndrome and Neurologic Injury Syndromesmentioning

confidence: 99%

Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs

Seneff¹,

Nigh

Kyriakopoulos³

et al. 2022

Food and Chemical Toxicology

103

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“…The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) flow chart is shown in figure 1. There were 34 studies of ON following COVID-19 infection,12–45 and an equal number of publications reported patients with ON post-COVID-19 vaccination 46–78. There were 19 case series and the remaining 49 were case reports.…”

Section: Resultsmentioning

confidence: 99%

Systematic review exploring the clinical features of optic neuritis after SARS-CoV infection and vaccination

Georganta,

Chasapi,

Smith

et al. 2023

BMJ Open Ophth

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BackgroundThis study aims to characterise the symptoms and clinical features of optic neuritis (ON) following SARS-CoV-2 infection and vaccination.MethodA literature search was conducted in four databases (PubMed, Medline, Embase and Google Scholar) to identify relevant case reports and case series. The records were screened and articles adhering to the inclusion criteria were critically appraised.ResultsSixty-eight studies were found to be eligible for inclusion, including 34 reporting ON following SARS-CoV-2 infection and an equal number reporting cases postvaccination. In total 93 patients and 125 eyes were included. The infection cohort included 42 patients and 56 eyes, 51.2% were female and 33.3% experienced bilateral ON. The mean visual acuity was 1.64 log of minimum angle of resolution (LogMAR), while pain was present in 77.8%. Oligoclonal bands were present in 3 patients, myelin oligodendrocyte glycoprotein (MOG) antibodies in 18 patients and AQP-4 antibodies in 4 patients. The vaccination cohort included 51 patients and 69 eyes. 60.8% were female and 35.3% had a bilateral ON. The mean visual acuity was 0.93 LogMAR. Oligoclonal bands were present in 46.7%, MOG antibodies in nine patients and AQP-4 antibodies in three patients.ConclusionPatients with ON post-SARS-CoV infection were more likely to experience severe visual impairment than in cases following vaccination. Further research is required to outline the clinical features of ON after COVID-19 infection and vaccination, and establish causality.

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“…Overexpression of Ang II is a causal factor in neurodegeneration of the optic nerve, causing optic neuritis, which can result in severe irreversible visual loss [180]. Multiple case reports have described cases of optic neuropathy appearing shortly after mRNA vaccination for COVID-19 [181,182]. Other debilitating neurological conditions are also appearing shortly after vaccination, where a causal relationship is suspected.…”

Section: Guillain Barré Syndrome and Other Neurological Conditionsmentioning

confidence: 99%

Innate Immune Suppression by SARS-CoV-2 mRNA Vaccinations: The role of G-quadruplexes, exosomes and microRNAs

Seneff

Nigh

Kyriakopoulos³

et al. 2022

Preprint

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The mRNA SARS-CoV-2 vaccines were brought to market in response to the widely perceived public health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious disease had no precedent, but desperate times seemed to call for desperate measures. The mRNA vaccines utilize genetically modified mRNA encoding spike proteins. These alterations hide the mRNA from cellular defenses, promote a longer biological half-life for the proteins, and provoke higher overall spike protein production. However, both experimental and observational evidence reveals a very different immune response to the vaccines compared to the response to infection with SARS-CoV-2. As we will show, the genetic modifications introduced by the vaccine are likely the source of these differential responses. In this paper, we present the evidence that vaccination, unlike natural infection, induces a profound impairment in type I interferon signaling, which has diverse adverse consequences to human health. We explain the mechanism by which immune cells release into the circulation large quantities of exosomes containing spike protein along with critical microRNAs that induce a signaling response in recipient cells at distant sites. We also identify potential profound disturbances in regulatory control of protein synthesis and cancer surveillance. These disturbances are shown to have a potentially direct causal link to neurodegenerative disease, myocarditis, immune thrombocytopenia, Bell’s palsy, liver disease, impaired adaptive immunity, increased tumorigenesis, and DNA damage. We show evidence from adverse event reports in the VAERS database supporting our hypothesis. We believe a comprehensive risk/benefit assessment of the mRNA vaccines excludes them as positive contributors to public health, even in the context of the Covid-19 pandemic.

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Inflammatory optic neuropathy following SARS-CoV-2 mRNA vaccine: Description of two cases

Cited by 6 publications

References 0 publications

Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs

Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs

Systematic review exploring the clinical features of optic neuritis after SARS-CoV infection and vaccination

Innate Immune Suppression by SARS-CoV-2 mRNA Vaccinations: The role of G-quadruplexes, exosomes and microRNAs

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