Inflammatory myopathies: Part 2

Abstract

Idiopathic Inflammatory MyopathiesPobmyositis and Dermutomyositis (continuation from Part I ) DIAGNOSIS. The diagnosis of polymyositis (PM) and dermatomyositis (DM) poses few problems when clinical findings are typical, serum creatine kinase (CK) levels are elevated, electromyography (EMG) shows multifocal myopathic changes with spontaneous potentials, and muscle biopsy confirms the presence of a necrotizing inflammatory process. However, in patients with atypical clinical features and normal enzyme levels, or in whom EMG and biopsy findings are normal or show inconclusive changes, a diagnostic system based on certain major clinical and laboratory criteria can be useful. The criteria listed below are based on those originally proposed by Bohan and Peter 1 191 and as From the Address "Part 1 was published in the March issue of Annals ofNeuvolog~ (17:215-227). Abstract and references are contained in Part 1. Dr 317 Mathews MB, Reichlin M, Hughes GRV, Bernstein RM: Antithreonyl-tRNA synthetase, a second myositis-related autoantibody. J Exp Med 160:420-434, 1984 Reichlin M, Maddison PJ, Targoff I, et al: Antibodies to a nuclear/ nucleolar antigen in patients with polymyoritis overlap syndromes.

Cutaneous manifestations of dermatomyositis in male patient: a rare report

“…In our study, onset age was 32 years. It is reported that females outnumber males by 2:1 [13,14]. We reported this in male patient.…”

“…The cutaneous lesions usually precede the onset of weakness by 3 to 6 months, [6] however, Pearson [11] has described one case, with skin involvement for 13 years. It is known that DM has a bimodal age distribution: one peak occurs in children between 5-14 yr of age and a second, larger peak occurs between 45-64 yr of age [13,14]. In our study, onset age was 32 years.…”

Fatores de risco associados à calcinose na dermatomiosite juvenil

“…Characterization of this group of pathologies is based on its pattern of muscle involvement, the presence of associated clinical manifestations, histopathological findings, response to treatment and prognosis. [4][5][6] This is a rare disease that predominantly affects females, at a proportion of 2:1, and which has an incidence of 3.2/ 1,000,000 children and adolescents/year in the United…”

Diagnosis of dermatomyositis and polymyositis: a study of 102 cases

“…Proximal muscle weakness and inflammatory infiltrates within the skeletal muscle characterize polymyositis (PM). When myositis is accompanied by characteristic skin lesions, it is called dermatomyositis (DM) [1][2][3][4] . The skin manifestations include a heliotrope rash (blue-purple discoloration) on the upper eyelids with edema, a flat red rash on the face and upper trunk, and erythema of the knuckles accompanied by a raised, violaceous scaly eruption (Gottron's sign).…”

“…The incidence of PM, DM and inclusion-body myositis is approximately 1 in 100,000 3,5 . The cause of those diseases is still ignored, but the existence of genetic factors and autoimmune mechanisms is known 1,2,4,6 . Viral and bacterial infections as well as some drugs can also be related with the etiology of the inflammatory myopathies, but this type of condition needs to be distinguished from the idiopathic form being discussed 4,[6][7][8][9][10] .…”