Inflammatory myopathies overlapping with systemic sclerosis: a systematic review

Gonçalves, Jucier; Mugii, Naoki; Inaoka, Pleiades Tiharu; Sampaio-Barros, Percival D.; Shinjo, Samuel Katsuyuki

doi:10.1007/s10067-022-06115-0

Cited by 7 publications

(9 citation statements)

References 46 publications

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“…The data are consistent with previous studies in which patients with Myo-SSc varied between 40 and 60 years old and were mostly women. [1][2][3]6,11,12,18,19 In the present study, it was possible to map cases of the natural history of Myo-SSc due to the long median follow up period of 98 (range, 37 to 168) months. The Brazilian group had longer follow-up time and longer current follow-up.…”

Section: Discussionmentioning

confidence: 95%

“…The data are consistent with previous studies in which patients with Myo-SSc varied between 40 and 60 years old and were mostly women. [ 1 - 3 , 6 , 11 , 12 , 18 , 19 ]…”

Section: Discussionmentioning

confidence: 99%

“…This finding is in line with the literature, in which Myos tend to be secondary to SSc involvement, ranging from 32 to 78%. [ 10 , 19 , 20 ] This variation can be explained by the absence of well-established and consensual criteria for defining the complex and varied clinical spectrum of muscle involvement in Myo-SSc. [ 12 ] Another possibility is the presence of external factors.…”

Section: Discussionmentioning

confidence: 99%

“…In the past five decades, epidemiological, histopathological, and laboratory studies have attempted to determine which phenotypes of patients with SSc would develop Myos and what impact this impairment has on these patients’ prognosis. [ 9 , 19 , 27 ] Several case reports from the 19 th century[ 2 , 3 ] referred to severe outcomes for these pathologies. In addition, patients with Myo-SSc are more severe, they tend to have a worse prognosis,[ 20 ] greater morbidities, impaired quality of life[ 11 ] and incidence of cardiac involvement.…”

Section: Discussionmentioning

confidence: 99%

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Patients with inflammatory myopathies overlapping with systemic sclerosis: A Brazilian-Japanese bicentric study

et al. 2022

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Objectives: This study aims to describe and compare the demographic, clinical, and laboratory characteristics and follow-up of representative samples of patients with myopathies and systemic sclerosis overlap syndromes (Myo-SSc) from two tertiary centers. Patients and methods: This is a cross-sectional and retrospective study conducted between January 2000 and December 2020. Fourty-five patients were analyzed with Myo-SSc (6 males, 39 females; mean age: 50.2±15.4 years; range, 45 to 65 years) from two tertiary centers (n=30 from Brazil and n=15 from Japan). Results: The median follow-up was 98 (range, 37 to 168) months. Muscle impairment started simultaneously with the diagnosis of systemic sclerosis in 57.8% (26/45) of cases. Muscle involvement occurred before the onset of systemic sclerosis in 35.5% (16/45) of cases, and after in 6.7% (3/45). Polymyositis was observed in 55.6% (25/45) of cases, followed by dermatomyositis in 24.4% (11/45) and antisynthetase syndrome in 20.0% (9/45). Concerning systemic sclerosis, the diffuse and limited forms occurred in 64.4% (29/45) and 35.6% (16/45) of the cases, respectively. Comparing the subgroups, Myo or SSc onset was earlier in Brazilian patients, and they had a higher frequency of dysphagia (20/45, [66.7%]) and digital ulcers (27/45, [90%]), whereas Japanese patients had higher modified Rodnan skin scores (15 [9 to 23]) and prevalence of positive anti-centromere antibodies (4/15 [23.7%]). The current disease status and mortality were similar in both groups. Conclusion: In the present study, Myo-SSc affected middle-aged women, and its manifestation spectrum varied according to geographic distribution.

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Section: Discussionmentioning

confidence: 95%

“…The data are consistent with previous studies in which patients with Myo-SSc varied between 40 and 60 years old and were mostly women. [ 1 - 3 , 6 , 11 , 12 , 18 , 19 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Patients with inflammatory myopathies overlapping with systemic sclerosis: A Brazilian-Japanese bicentric study

et al. 2022

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“…Recently, predominant fibrosis or a fibrosing myopathy has gained recognition as the unique histopathological finding among patients with SSc-AM [9]. It is also well recognized that inflammatory muscle disease can occur in SSc, in the setting of overlap idiopathic inflammatory myopathy (IIM), described as ‘scleromyositis’ [10,11 ▪▪ ] or ‘myopathies and systemic sclerosis overlap syndrome’ [12]. Other causes of SSc-AM include neurogenic myopathy in the setting nervous system involvement, myopathy due to poor nutritional state (particularly among those with gastrointestinal involvement) and disuse myopathy (particularly among those with significant skin/contractures or poor reserve in the setting of cardiopulmonary disease) [4] (Fig.…”

Section: What Is Systemic Sclerosis Associated Myopathy?mentioning

confidence: 99%

Myopathy in systemic sclerosis

Connolly,

Paik

2023

Current Opinion in Rheumatology

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Purpose of review Systemic sclerosis associated myopathy (SSc-AM) is a complex, heterogenous disease that is associated with poor outcomes. SSc-AM lacks a clear definition, and continues to be poorly recognized. The purpose of this review is to provide a contemporary overview of the clinical, serological and pathophysiologic findings in SSc-AM to guide optimal recognition and management of this challenging disease manifestation. Recent findings There have been several advances in diagnostic techniques to facilitate characterization of SSc-AM, including muscle MRI, in which findings were correlated to distinct histopathologic categories of muscle involvement in SSc, histopathologic findings of prominent fibrosis or inflammation on biopsy, and the identification of novel autoantibodies associated with SSc-AM, which may be associated with distinct clinical phenotypes. In one of the largest studies to date, 17% of a well phenotyped SSc cohort were found to have myopathy, which was an independent risk of death, even after adjusting for potential confounders, further highlighting the importance of timely recognistion and management of SSc-AM. Summary There is increasing recognition of the importance of SSc-AM. Novel diagnostic tools provide the opportunity for more detailed insights into pathophysiologic mechanisms, which may facilitate the development of a rigorous consensus definition of SSc-AM.

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Managing gastrointestinal manifestations in systemic sclerosis, a mechanistic approach

Kaniecki,

Hughes,

McMahan

2024

Expert Review of Clinical Immunology

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Inflammatory myopathies overlapping with systemic sclerosis: a systematic review

Cited by 7 publications

References 46 publications

Patients with inflammatory myopathies overlapping with systemic sclerosis: A Brazilian-Japanese bicentric study

Patients with inflammatory myopathies overlapping with systemic sclerosis: A Brazilian-Japanese bicentric study

Myopathy in systemic sclerosis

Managing gastrointestinal manifestations in systemic sclerosis, a mechanistic approach

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