Inflammatory Myofibroblastoma of the Breast: A Case Report

Wei, Liwen; Jiang, Guoyuan; Bai, Lala; Li, Tingchao; Ma, Xuejin; Jiang, Lin; Wang, Jie; Li, Shiguang

doi:10.3389/fonc.2021.646336

Cited by 4 publications

(4 citation statements)

References 23 publications

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“…When we searched PubMed using the keyword “inflammatory myofibroblast tumor of the breast” and excluded the proceedings published from 1988 to 2022, we found 4325 reports of IMT worldwide. Among them, only 35 described IMT arising in the breast; our case is the 36th (Table 1 ) [ 6 – 36 ]. IMT was first reported in the lungs in 1939 [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…Gleason and Hornick [ 40 ] also reported that the recommended treatment is complete surgical excision and that recurrence rates of up to 25% are experienced. Furthermore, many reports have emphasized the importance of preoperative examination to determine the most appropriate surgical procedure [ 23 , 27 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, many reports have emphasized the importance of preoperative examination to determine the most appropriate surgical procedure [ 23 , 27 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…ALK is a receptor tyrosine kinase that has been conserved across species. Recent studies have shown that chromosomes 2 and 9 are abnormal in IMT, and more than half of IMTs exhibit fusion of ALK genes on 2p23 [ 36 ]. The ALK-1 expression rate is reportedly about 40% to 50% in IMT arising in the breast [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

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Anaplastic lymphoma kinase-positive inflammatory myofibroblastic tumor of the breast: a case report and review of the literature

Kawakita,

Anan,

Kurata

et al. 2023

surg case rep

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Background Few reports of inflammatory myofibroblastic tumor (IMT) of the breast have been published worldwide. Furthermore, primary anaplastic lymphoma kinase (ALK)-positive IMT of the breast is extremely rare. To date, only six patients with ALK-positive IMT have been reported in the literature. Case presentation A 52-year-old woman underwent a medical examination, and a left breast mass was detected. She did not feel a mass in her chest. Mammography showed a focal asymmetric density at the lower outer portion of the left breast. Breast ultrasonography showed a 1.2-cm hypoechoic lesion with relatively clear boundaries and poor blood flow. Magnetic resonance imaging and computed tomography revealed a solitary heterogeneous mass in the left breast. Pathologic examination revealed a fibrosing lesion with proliferation of fibroblastic cells arranged in a storiform pattern and admixed inflammatory cells. Immunohistochemical examination showed that the tumor cells were positive for ALK. Under the preoperative diagnosis of IMT, we performed partial mastectomy with adequate margins. The postoperative diagnosis was pathologically confirmed as IMT. Immunohistochemical staining also showed overexpression of ALK-1 in the tumor. The patient had a good clinical course for 24 months postoperatively, without recurrence or metastasis. Conclusions IMT of the breast shows nonspecific imaging findings, making preoperative diagnosis difficult. Nevertheless, IMT has the characteristics of low-grade neoplasms with recurrence, invasion, and metastatic potential. Our report emphasizes the importance of determining a treatment plan as soon as possible based on an accurate diagnosis to improve the prognosis of this disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Furthermore, many reports have emphasized the importance of preoperative examination to determine the most appropriate surgical procedure [ 23 , 27 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Anaplastic lymphoma kinase-positive inflammatory myofibroblastic tumor of the breast: a case report and review of the literature

Kawakita,

Anan,

Kurata

et al. 2023

surg case rep

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Clinicopathological Features of Inflammatory Myofibroblastic Tumor in the Breast

et al. 2022

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Inflammatory myofibroblastic tumor (IMT) is a mesenchymal spindle cell tumour with low malignant potential which is extremely rare in breasts. Because of the lack of typical imaging and clinical characteristics of IMT, it is easy to misdiagnose before operation. We now report a case of a 37-year-old woman presenting with a mass in her left breast. Ultrasound showed a well-circumscribed lesion in the lower outer quadrant. The patient underwent lumpectomy, and histopathology revealed a tumor which was composed of fusiform cells and inflammatory cells. Immunohistochemistry (IHC) showed tumor cells are positive for vimentin, ALK, BCL2, and SMA. The FISH test demonstrated ALK (2p23) chromosomal translocation (ALK positive). The final diagnosis of breast IMT was rendered with nonclassical morphology. Postoperative 30-month follow-up no evidence showed residual tumor or recurrence. As a very rare tumor, breast IMT could be easily misdiagnosed clinically and pathologically. Complete surgical resection of the tumor is preferred, and it has the risk of recurrence and metastasis.

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