‘Inflammatory myofibroblastic tumour’‐like dedifferentiation of anaplastic lymphoma kinase‐rearranged lung adenocarcinoma

Abstract

Our findings suggest that ALK-driven epithelial and mesenchymal neoplasms exist on a morphological spectrum, and emphasize the need to consider translocation testing in pulmonary tumours with unusual sarcomatoid morphology.

Mesenchymal tumours of the pleura: review and update

“…The staining patterns (cytoplasmic, membranous, perinuclear, and/or nuclear) depends on the fusion partners. ALK immunoreactivity can be seen in other tumours with ALK fusion (such as a subset of non‐small‐cell lung carcinomas) or without ALK fusion (such as angiomatoid fibrous histiocytoma) 152,153 . In cases with unusual clinicopathologic features, orthogonal methods such as fluorescence in situ hybridisation testing and targeted next‐generation sequencing can be employed for diagnostic confirmation.…”