Inflammatory myofibroblastic tumors in children: literature review

Сулейманова, А. М.; Качанов, Д. Ю.; Имянитов, Е. Н.; Рощин, В. Ю.; Шаманская, Т. В.; Варфоломеева, С. Р.

doi:10.21682/2311-1267-2020-7-2-64-77

Ross. ž. det. gematol. onkol.

2020

DOI: 10.21682/2311-1267-2020-7-2-64-77

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Inflammatory myofibroblastic tumors in children: literature review

А. М. Сулейманова

Д. Ю. Качанов

Е. Н. Имянитов

et al.

Abstract: Inflammatory myofibroblastic tumor (IMT) is a rare type of neoplasm with undetermined biological potential. IMT can occur in both childhood and adulthood. The standard of therapy is radical surgical treatment, but for patients with inoperable/recurrent or metastatic forms of IMT, therapeutic options are very limited. This literature review describes specific clinical, morphological and biological characteristics of this neoplasm, provides modern approaches to the diagnosis and treatment of IMT. Show more

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Difficulties in diagnosing a myofibroblastic lung tumor in a child

Belykh,

Zakharova,

Piznyur

et al. 2023

Med. vestn. Ûga Ross.

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Inflammatory myofibroblastic tumor (VMO) is a rare neoplasm, which is currently referred to as a mesenchymal neoplasm with intermediate biological potential. The tumor consists of differentiated myofibroblastic fusiform cells. The frequency of occurrence of VMO among primary lung neoplasms is up to 1%. This type of tumor is the most common type of primary lung tumors in children. VMO can occur both in childhood and in adulthood. VMO is found in the soft tissues of the abdominal cavity, in the pelvic organs, larynx, mammary gland, head and neck tissues. Extra-organ localization (retroperitoneal space, mediastinum) is also diagnosed. Lung VMO often has no clinical manifestations, and if present has nonspecific symptoms, such as cough, hemoptysis, shortness of breath, hyperthermia, chest pain. VMO was previously considered as a neoplasm with a benign course, but these tumors tend to local relapses and distant metastasis. The article presents data on the prevalence, clinical manifestations and treatment of VMO, as well as own clinical observation of the course of this disease in an 8-year-old child.

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Difficulties in diagnosing a myofibroblastic lung tumor in a child

Belykh,

Zakharova,

Piznyur

et al. 2023

Med. vestn. Ûga Ross.

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Myxofibrosarcoma of the heart: case series

Makarov

Mitrofanova

Antonova

et al. 2022

Vestnik aritmologii

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Intraluminal formations of the heart are a heterogeneous group: from blood clots to malignant neoplasms. The nosology of these formations can only be determined by morphological research. Myxofibrosarcoma of the heart is a rare malignant tumor. According to modern concepts, myxofibrosarcoma belongs to the group of intimal sarcomas, subgroup of undifferentiated pleomorphic sarcomas. We describe two cases of myxofibrosarcoma of the heart: in one subject against the background of inflammatory myofibroblastic heart tumor; in another subject - with a history of breast cancer and diffuse large B-cell lymphoma. An attempt was made to identify similar mutations in patients with these tumors according to the literature.

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Inflammatory myofibroblastic tumors in children: literature review

Cited by 2 publications

References 56 publications

Difficulties in diagnosing a myofibroblastic lung tumor in a child

Difficulties in diagnosing a myofibroblastic lung tumor in a child

Myxofibrosarcoma of the heart: case series

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