Inflammatory myofibroblastic tumor with extensive involvement of the bladder in an adolescent: a case report

Yi, Xin; Lu, None Hao; Wu, Yue; Li, Wen Hui; Meng, Qing Gui; Ji, Cheng; Tang, Yong; Liu, Yu; Bai, Xian Zhong

doi:10.1186/1477-7819-11-206

Cited by 7 publications

(7 citation statements)

References 17 publications

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“…Tumors affecting this site usually appear as polypoid intraluminal or submucosal masses with or without extension into the perivesical fat [ 138 ], although a tough, diffuse lesion featuring uneven thickening of the bladder has been described [ 139 ]. Histologically, inflammatory myofibroblastic tumor is characterized by a proliferation of spindled cells arranged in cellular fascicles admixed with inflammatory cells including plasma cells, and lymphocytes.…”

Section: Inflammatory Myofibroblastic Tumor (Imt)mentioning

confidence: 99%

Genetics of Bladder Malignant Tumors in Childhood

Zangari¹,

Zaini²,

Gulìa³

2015

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Bladder masses are represented by either benign or malignant entities. Malignant bladder tumors are frequent causes of disease and death in western countries. However, in children they are less common. Additionally, different features are found in childhood, in which non epithelial tumors are more common than epithelial ones. Rhabdomyosarcoma is the most common pediatric bladder tumor, but many other types of lesions may be found, such as malignant rhabdoid tumor (MRT), inflammatory myofibroblastic tumor and neuroblastoma. Other rarer tumors described in literature include urothelial carcinoma and other epithelial neoplasms. Rhabdomyosarcoma is associated to a variety of genetic syndromes and many genes are involved in tumor development. PAX3-FKHR and PAX7-FKHR (P-F) fusion state has important implications in the pathogenesis and biology of RMS, and different genes alterations are involved in the pathogenesis of P-F negative and embryonal RMS, which are the subsets of tumors most frequently affecting the bladder. These genes include p53, MEF2, MYOG, Ptch1, Gli1, Gli3, Myf5, MyoD1, NF1, NRAS, KRAS, HRAS, FGFR4, PIK3CA, CTNNB1, FBXW7, IGF1R, PDGFRA, ERBB2/4, MET, BCOR. Malignant rhabdoid tumor (MRT) usually shows SMARCB1/INI1 alterations. Anaplastic lymphoma kinase (ALK) gene translocations are the most frequently associated alterations in inflammatory myofibroblastic tumor (IMT). Few genes alterations in urothelial neoplasms have been reported in the paediatric population, which are mainly related to deletion of p16/lnk4, overexpression of CK20 and overexpression of p53. Here, we reviewed available literature to identify genes associated to bladder malignancies in children and discussed their possible relationships with these tumors.

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Section: Inflammatory Myofibroblastic Tumor (Imt)mentioning

confidence: 99%

Genetics of Bladder Malignant Tumors in Childhood

Zangari¹,

Zaini²,

Gulìa³

2015

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“…The IMTUB invaded the peritoneum, ileocecal junction, greater omentum, appendix, and other tissues in two reported cases (12,23). Encouragingly, there was no local recurrence or distant metastasis in either adolescent after 6-12 months (12,23). The tumor may be characterized by aggressive growth if it extends to tissues outside the bladder, such as the peritoneum, greater omentum, and ileocecal region.…”

Section: Discussionmentioning

confidence: 93%

“…Concerning genes, IMT may be more related to the clonal chromosomal rearrangement of ALK than PSCN. Leiomyosarcomas and sarcomatoid carcinomas usually lack ALK expression, especially when necrosis is present ( 2 , 12 , 13 ). A meta-analysis indicated that ALK played an important role in diagnosing and distinguishing IMTUB ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Myofibroblastic Tumor of the Urinary Bladder: An 11-Year Retrospective Study From a Single Center

Chen

Huang

et al. 2022

Front. Med.

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PurposeTo share our experience in the diagnosis and treatment of an inflammatory myofibroblastic tumor of the urinary bladder (IMTUB).Materials and MethodsA database searches in the pathology archives by using the term “inflammatory myofibroblastic tumor” and” bladder” in our hospital department of pathology from 2010 to 2021. Patient characteristics, clinical features, histopathological results, immunohistochemical staining results, and treatment outcomes were reviewed.ResultsFourteen cases of IMTUB were retrieved. The mean age was 44.7 ± 18.9 years (range 12–74). Nine (64.3%) of the patients presented with hematuria, followed by seven (50%) with odynuria, five (35.7%) with urgent urination, and one (7.1%) with dysuria. Ten (71.4%) of the patients were treated with partial cystectomy (PC), three (21.4%) with transurethral resection of bladder tumor (TURBT), and one (7.1%) with radical cystectomy (RC). Histopathologically, eight (57.1%) had a compact spindle cell pattern. Anaplastic lymphoma kinase (ALK) staining was positive in six (75%) of 8 cases. During a mean follow-up period of 43.9 ± 38 months (range 3–117), a patient had recurrence within half a month. Then, the patient was treated with further TURBT surgery and had no recurrence within 6 months. Thirteen of the patients had no local recurrence or distant metastasis.ConclusionInflammatory myofibroblastic tumor of the urinary bladder (IMTUB) is clinically rare and has a good prognosis. The disease is mainly treated with surgery to remove the tumor completely. It can easily be misdiagnosed as bladder urothelial carcinoma, leiomyosarcoma, or rhabdomyosarcoma, which may result in overtreatment and poor quality of life of patients.

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“…However, among the children’s laryngeal IMT reports, the only ALK-positive case had no recurrence, and the one recurrent case was ALK-negative [ 4 , 7 ]. In other anatomic locations, there are many reports of ALK-negative IMTs showing invasive biological behavior [ 23 - 25 ]. Accordingly, we think that complete resection of the tumor with negative surgical margins is the key to preventing recurrence.…”

Section: Discussionmentioning

confidence: 99%

Recurrent laryngeal inflammatory myofibroblastic tumor with positive anaplastic lymphoma kinase mimicking recurrent respiratory papillomatosis: a case report

Dong

Liu

2014

World J Surg Onc

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Inflammatory myofibroblastic tumor (IMT) of the larynx is an unusual lesion, particularly in the pediatric age group. Laryngeal IMTs in children follow a benign clinical course with reports of only rare recurrences and no metastases. Although anaplastic lymphoma kinase (ALK) has been associated with IMTs, there is only one pediatric laryngeal IMT reported to be ALK-positive with immunohistochemical staining. Here, we present a case of a 10-year-old boy with a laryngeal IMT that recurred four times and was misdiagnosed as recurrent respiratory papillomatosis after the initial three operations. ALK positivity was demonstrated by both immunohistochemical staining and fluorescence in situ hybridization. To the best of our knowledge, this case report is the first to describe a laryngeal IMT that recurred multiple times and was confirmed to be ALK-positive at the molecular level.

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Inflammatory myofibroblastic tumor with extensive involvement of the bladder in an adolescent: a case report

Cited by 7 publications

References 17 publications

Genetics of Bladder Malignant Tumors in Childhood

Genetics of Bladder Malignant Tumors in Childhood

Inflammatory Myofibroblastic Tumor of the Urinary Bladder: An 11-Year Retrospective Study From a Single Center

Recurrent laryngeal inflammatory myofibroblastic tumor with positive anaplastic lymphoma kinase mimicking recurrent respiratory papillomatosis: a case report

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