Inflammatory myofibroblastic tumor of the prostate after transurethral resection of the prostate with negative expression of anaplastic lymphoma kinase: a case report

Abstract

Inflammatory myofibroblastic prostate tumors are rare lesions with unclear etiology. The pathological diagnosis is very important.

A Rare Case of Inflammatory Myofibroblastic Tumor of the Prostate and Review of the Literature

“…Upon examination of the cases of prostatic IMT reported in the English literature (7)(8)(9)(10)(11)(12)(13)(14), it was found to occur in various age groups (21-83 years old) but commonly in the elderly (mean age=60.8 years), and the chief complaint of patients was urinary obstruction symptoms, which were occasionally accompanied by hematuria or fever. In some patients there was difficulty in accurately assessing the size of the tumor because although the tumor was diagnosed through transurethral resection of the prostate (TUR-P) and transperineal biopsy, the diameters ranged from 1.2 to 6.5 cm.…”

“…Previous injury or suspicious findings were present in: five out of 10 cases with a 10-month (12) or 4-year TUR-P history (14); those with a 4-year history of irradiation to the prostate and transurethral resection of bladder tumor 1 month earlier (11); those with a 2.5-year history of infarction-associated lesions from TUR-P (8); and in the present case, with suspected prostatic abscess findings 13 months earlier. Prior to the confirmation of the IMT diagnosis, prostatic IMT was diagnosed as nodular hyperplasia in most biopsy examinations and were diagnosed as low-grade sarcoma (7).…”

“…Since the discovery of the alteration of anaplastic lymphoma kinase (ALK) gene in such bladder lesions, the lesions are treated as the result of neoplastic rather than reactive processes, and the name IMT has been preferred (4)(5)(6). Prostate IMT is rare, and only nine cases have been recorded in the English literature since it was first reported in 1984 as an atypical fibromyxoid tumor (7)(8)(9)(10)(11)(12)(13)(14).…”