Inflammatory myofibroblastic tumor of the skin grossly mimicking squamous cell carcinoma: A case report

Inoue, Takuya; Misago, Noriyuki; Okawa, Takeshi; Narisawa, Yutaka

doi:10.1111/j.1346-8138.2011.01217.x

Cited by 7 publications

(11 citation statements)

References 9 publications

(21 reference statements)

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“…Although the lung is the best known and most common site, IMT can occur in many organs. Only few cases occurring in the skin have been previously reported, so that cutaneous IMT should be considered as a diagnosis of exclusion . The spindle cells usually express vimentin and smooth muscle actin and approximately 50% of IMT are positive for p80/ALK1.…”

Section: Discussionmentioning

confidence: 99%

Atypical fibrous histiocytoma of the skin with CD30 and p80/ALK1 positivity and ALK gene rearrangement

Szablewski

Laurent-Roussel

Rethers³

et al. 2014

J Cutan Pathol

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We report the case of a two patients who presented with a solitary, asymptomatic, angiomatoid nodule on the right thigh. Histopathological finding showed a poorly circumscribed lesion, located in the dermis. The morphological aspect strongly suggested the diagnosis of atypical fibrous histiocytoma (AFH), but surprisingly, the neoplastic cells were diffusely CD30+, with a membrane staining devoid of paranuclear dot. The lesions were tested for p80/ALK1 expression. Surprisingly, we found a diffuse cytoplasmic positivity. Interestingly, using break-apart fluorescent in situ hybridization (FISH), we evidenced an ALK rearrangement in nearly 50% of the neoplastic cells. The expression of CD30 and ALK1 with ALK gene rearrangement raised the possibility of three diagnoses: a primary cutaneous anaplastic large cell lymphoma (ALCL), a cutaneous inflammatory myofibroblastic tumor (IMT), an AFH of the skin associated with ALK gene rearrangement and CD30 positivity. The three hypotheses were discussed and finally, although p80/ALK1 expression and cytogenetic abnormalities in fibrous histiocytoma (FH) are not yet reported to the best of our knowledge, we favored the diagnosis of AFH.

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Section: Discussionmentioning

confidence: 99%

Atypical fibrous histiocytoma of the skin with CD30 and p80/ALK1 positivity and ALK gene rearrangement

Szablewski

Laurent-Roussel

Rethers³

et al. 2014

J Cutan Pathol

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“…We report here, for the first time, four cases of ALK‐positive cutaneous IMT. To date, rare cases of IMT with a cutaneous localization have been reported . The six cases immunostained with ALK1 antibody were negative, leading us to use another ALK antibody, as staining discrepancies depending on the employed ALK antibodies have already been reported .…”

Section: Discussionmentioning

confidence: 99%

“…To date, rare cases of IMT with a cutaneous localization have been reported. [3][4][5][6][7][8][9][10][11] The six cases immunostained with ALK1 antibody were negative, 7,8 antibody, as staining discrepancies depending on the employed ALK antibodies have already been reported. 12,13 In our study, the two ALK antibodies used gave clear cytoplasmic reactivity, with no detectable difference in staining intensity.…”

Section: Discussionmentioning

confidence: 99%

“…However, on the basis of clinical, pathological and molecular features, IMTs appear to constitute a distinct entity within the broad category of inflammatory pseudotumours . They have been reported in a wide range of anatomical locations (lung, abdominopelvic region, retroperitoneum, and soft tissue), but only 16 have been reported in skin . Here, we report four cases, one in a child and three in young adults.…”

Section: Introductionmentioning

confidence: 88%

“…2 They have been reported in a wide range of anatomical locations (lung, abdominopelvic region, retroperitoneum, and soft tissue), but only 16 have been reported in skin. [3][4][5][6][7][8][9][10][11] Here, we report four cases, one in a child and three in young adults. Interestingly, they were all ALK-positive.…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous inflammatory myofibroblastic tumours can be anaplastic lymphoma kinase‐positive: report of the first four cases

et al. 2015

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Fibrous, Fibrohistiocytic, and Myofibroblastic Tumors of Intermediate Malignancy

Singh

Udager

Billings

2018

Soft Tissue Tumors of the Skin

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Inflammatory myofibroblastic tumor of the skin grossly mimicking squamous cell carcinoma: A case report

Cited by 7 publications

References 9 publications

Atypical fibrous histiocytoma of the skin with CD30 and p80/ALK1 positivity and ALK gene rearrangement

Atypical fibrous histiocytoma of the skin with CD30 and p80/ALK1 positivity and ALK gene rearrangement

Cutaneous inflammatory myofibroblastic tumours can be anaplastic lymphoma kinase‐positive: report of the first four cases

Fibrous, Fibrohistiocytic, and Myofibroblastic Tumors of Intermediate Malignancy

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