Inflammatory myofibroblastic tumor of the pancreatic head

Lacoste, L; Galant, Christine; Gigot, Jean‐François; Lacoste, B; Annet, Laurence

doi:10.5334/jbr-btr.638

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…Primary mesenchymal tumors of the pancreas comprise only 1-2% of all pancreatic neoplasms (1), and the literature on mesenchymal tumors involving the pancreas is largely limited to case reports or analyses of small series (3,(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Here, we present a large series of mesenchymal tumors involving the pancreas, discuss their clinicopathologic features and differential diagnoses, and compare our findings with the previous experience reported in the literature.…”

Section: Introductionmentioning

confidence: 65%

“…In the literature, the most commonly reported primary benign/borderline mesenchymal tumors were schwannoma followed by inflammatory myofibroblastic tumor, whereas the most commonly reported malignant ones were leiomyosarcoma and undifferentiated sarcomas (3,(6)(7)(8)(9)(10)(11)(19)(20)(21)(22)(23). In our series, the most common benign/borderline mesenchymal tumors involving the pancreas were solitary fibrous tumor (n=9), followed by schwannoma (n=4), and the most common malignant ones were leiomyosarcoma (n=6), followed by liposarcoma (n=4).…”

Section: Discussionmentioning

confidence: 99%

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Mesenchymal tumors involving the pancreas: a clinicopathologic analysis and review of the literature

Askan¹,

Baştürk²

2021

TJPATH

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Objective: Most pancreatic tumors are epithelial, and, among these, more than 90% are of ductal origin. However, a variety of mesenchymal tumors may involve the pancreas and may manifest different clinicopathological characteristics. The literature on mesenchymal tumors in the pancreas is largely limited to individual case reports or analyses of small series, predominantly focusing on radiologic features. Material and Method:Authors' institutional and consultation databases were reviewed to identify the mesenchymal tumors involving the pancreas.Results: Forty cases were identified; twenty-five (63%) tumors were benign/borderline, and the remaining fifteen (37%) were malignant. Of the benign/borderline tumors; 9 were solitary fibrous tumors, 6 gastrointestinal stromal tumors (GISTs), 4 schwannomas, 2 desmoid type fibromatosis, 1 lymphangioma, 1 ganglioneuroma, 1 inflammatory myofibroblastic tumor, and 1 low grade mesenchymal neoplasm. Malignant tumors included 6 cases of leiomyosarcomas, 4 liposarcomas, 2 rhabdomyosarcomas, 1 epithelioid angiosarcoma, 1 malignant peripheral nerve sheet tumor, and 1 undifferentiated pleomorphic sarcoma. Four cases (multicystic schwannoma, desmoid fibromatosis, lymphangioma and inflammatory myofibroblastic tumor) were preoperatively misdiagnosed as a primary epithelial tumor of the pancreas. Conclusion:Mesenchymal tumors rarely involve the pancreas. They are usually benign/borderline neoplasms but may be diagnostically challenging, especially clinically/radiologically, as they may form cystic and/or large lesions in the pancreas. Mesenchymal tumors should be considered in both the clinical/radiological and pathological differential diagnosis of pancreatic lesions.

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Section: Introductionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Mesenchymal tumors involving the pancreas: a clinicopathologic analysis and review of the literature

Askan¹,

Baştürk²

2021

TJPATH

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“…Contrast enhancement in computed tomography is variable (60, 61); however, 18 F-FDG-PET/CT is suitable for diagnosis. (22, 30, 57, 60, 62, 63)…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Pseudotumor (IPT) and Inflammatory Myofibroblastic Tumor (IMT): A Representative Literature Review Occasioned by a Rare IMT of the Transverse Colon in a 9-year-old Child

Höhne

Milzsch

Adams

et al. 2015

Tumori

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The liver and biliary tract were the most commonly affected of all body regions, at 32%. This was followed by the lung, including the respiratory tract, at 27%, and by the gastrointestinal tract, at 10%. Lesions of the large bowel, as in the present case of a 9-year-old boy, are very rare. There were organ-related as well as nonspecific clinical symptoms, such as fever, weight loss, and fatigue. Laboratory test results revealed anemia and elevated inflammation-dependent parameters. The patterns in medical imaging are variable and nonspecific. Morphology often suggests a malignant process. For this reason, therapy in most cases is surgical, but this is required more often in IMTs. Many IPTs could be treated conservatively.

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“…Although numerous primary mesenchymal tumors of the pancreas have been reported, the majority of cases were reported as case reports (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). To the best of our knowledge, there has been only one comprehensive study of these tumors in a single institution (3).…”

Section: Introductionmentioning

confidence: 99%

Primary mesenchymal tumors of the pancreas in a single center over 15 years

Zhang

Wang

et al. 2016

Oncology Letters

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Abstract. In total, 95% of primary tumors in the pancreas are epithelial tumors; primary mesenchymal tumors at this site are extremely rare. At present, only one comprehensive study about these rare tumors has been performed. Another retrospective analysis of these rare tumors is performed in the present study, which, to the best of our knowledge, is the first to be performed in China. In the present study, 10 patients that underwent resection for primary mesenchymal tumors of the pancreas were identified in a 15-year period at the Chinese Academy of Medical Sciences and Peking Union Medical College, which accounted for 0.51% of the total surgically resected primary tumors of the pancreas at this hospital. Among the 10 patients, 7 patients (70%) were diagnosed with benign/borderline tumors, and the remaining 3 patients (30%) were diagnosed with malignant tumors. It was a unique finding of the present study that the preoperative diagnosis was frequently a misdiagnosis, in terms of the specific pathological diagnosis. Therefore, although primary mesenchymal tumors of the pancreas are extremely rare, they should be considered in order to make the correct preoperative diagnosis. Contrarily to a previous study, in the present study, the most common benign tumor was not desmoid tumor, but solitary fibrous tumors; the most frequent primary sarcoma was not undifferentiated/unclassified sarcoma either. In conclusion, the present study aids the understanding of these rare tumors; however, primary mesenchymal tumors of the pancreas require additional exploration in the future. IntroductionThe predominant primary tumor that occurs in the pancreas is ductal adenocarcinoma (1). Stroma is scant in the normal pancreas, and therefore primary mesenchymal tumors of the pancreas are extremely rare (2).Although numerous primary mesenchymal tumors of the pancreas have been reported, the majority of cases were reported as case reports (3-22). To the best of our knowledge, there has been only one comprehensive study of these tumors in a single institution (3). A lack of comprehensive studies from other large institutes to provide a comprehensive understanding of this type of tumor remains. In the present study, a thorough retrospective analysis of primary mesenchymal tumors of the pancreas in Peking Union Medical College Hospital (Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China) was performed and the relevant studies published in the English literature were reviewed.According to the published studies, at present there have been 221 cases of primary mesenchymal tumors of the pancreas reported in the English literature (3). Among these, the most commonly reported primary benign/borderline mesenchymal tumors of the pancreas were schwannomas, followed by inflammatory myofibroblastic tumors, solid and cystic hamartomas, and solitary fibrous tumors. In addition, the most frequently reported primary malignant mesenchymal tumors of the pancreas were leiomyosarcomas, followed by Ewing sarcomas/primitive neur...

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Inflammatory myofibroblastic tumor of the pancreatic head

Cited by 6 publications

References 6 publications

Mesenchymal tumors involving the pancreas: a clinicopathologic analysis and review of the literature

Mesenchymal tumors involving the pancreas: a clinicopathologic analysis and review of the literature

Inflammatory Pseudotumor (IPT) and Inflammatory Myofibroblastic Tumor (IMT): A Representative Literature Review Occasioned by a Rare IMT of the Transverse Colon in a 9-year-old Child

Primary mesenchymal tumors of the pancreas in a single center over 15 years

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