Inflammatory myofibroblastic tumor of gall bladder

Muduly, Dillip Kumar; Deo, S.V.S.; Shukla, Nootan Kumar; Manjunath, N; Durgapal, Prashant; Kallianpur, Ashwin A

doi:10.7869/tg.2012.79

Cited by 10 publications

(5 citation statements)

References 3 publications

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“…Gallbladder inflammatory pseudotumor is a kind of nonspecific chronic proliferative inflammation of the gallbladder, which can occur at any age, most of which are middle-aged people ( 5 ). GIPT reports are rare and easily misdiagnosed as gallbladder cancer.…”

Section: Discussionmentioning

confidence: 99%

Application of 18F-FDG PET/CT imaging in gallbladder inflammatory pseudotumor with elevated CA199: a case report and review of literature

Mingyan

et al. 2023

Front. Oncol.

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BackgroundGallbladder inflammatory pseudotumor (GIPT) is a nonspecific chronic proliferative inflammation of the gallbladder. At present, the pathogenesis is not clear, which may be related to bacterial and viral infections, congenital diseases, gallstones, chronic cholangitis and so on. GIPT is rare and the imaging examination has no obvious specificity. There are few reports on the 18F-FDG PET/CT imaging characteristics of GIPT. In this paper, 18F-FDG PET/CT findings of GIPT with elevated CA199 are reported and the literature is reviewed.Case descriptionA 69-year-old female patient presented with recurrent intermittent right upper abdominal pain for more than 1 year, followed by nausea and vomiting for 3 hours, without fever, dizziness, chest tightness and other symptoms. Complete CT, MRI, PET/CT and related laboratory tests, CEA (-), AFP (-), Ca199 224.50U/mL ↑,18F-FDG PET/CT images showed uneven thickening at the bottom of the gallbladder, slightly increased gallbladder volume, eccentric and localized thickening of the gallbladder body wall, nodular soft tissue density shadow, clear boundary, smooth gallbladder wall, presence and smooth hepatobiliary interface, increased FDG radioactivity uptake, SUVmax was 10.2.The tumor was resected after operation and was diagnosed as gallbladder inflammatory pseudotumor by postoperative pathology.Conclusion18F-FDGPET/CT imaging has a certain significance for gallbladder inflammatory pseudotumor. In patients with chronic cholecystitis, when the CA199 increases, the gallbladder wall appears localized thickening, the hepatobiliary interface exists and is smooth, and the 18F-FDG metabolism is mildly to moderately increase. Gallbladder cancer cannot be diagnosed alone, and the possibility of gallbladder inflammatory pseudotumor should also be considered. However, it should be noted that the cases with unclear diagnosis should still be actively treated with surgery, so as not to delay the treatment opportunity.

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Section: Discussionmentioning

confidence: 99%

Application of 18F-FDG PET/CT imaging in gallbladder inflammatory pseudotumor with elevated CA199: a case report and review of literature

Mingyan

et al. 2023

Front. Oncol.

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“…Although IMT is usually found in children and young adults, the IMT of the gallbladder mostly presented in late middle age. The youngest reported case of IMT of gallbladder was in a 35 year-old [ 4 ]. All cases were symptomatic, with abdominal pain being the most frequently found symptom.…”

Section: Discussionmentioning

confidence: 99%

“…We have searched extensively through medical databases, using the keywords; IMT OR "infammatory myofbroblastic tumor" OR "pseudotumor" OR "infammatory fbroblastic" AND gallbladder, and found seven reported cases of IMT of gallbladder. In all of these, the disease mainly involved the gallbladder and one adjacent organ [3][4][5][6][7][8][9] (Table 1). All reported cases of IMT of the gallbladder, including our case, share many similar unique features.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Myo-Fibroblastic Tumor of the Gallbladder with Multivisceral Involvement: Successful Treatment with Radical Surgery

Losuwarat

Luvira

Thanasukarn

et al. 2023

Case Reports in Hepatology

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Inflammatory myo-fibroblastic tumor (IMT) of the gallbladder is an extremely rare condition. Only seven cases have been reported. All of these were presented either with polyp/mass inside the gallbladder or gallbladder wall thickening, involving just one adjacent organ. We herein present a case of IMT of gallbladder presenting with a huge mass replacing the gallbladder with multiple organ involvement, successfully treated by en bloc multivisceral resection. Moreover, we have compared it with the characteristics of all reported cases of IMT of the gallbladder.

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“…There is also a limited number of case reports in the literature indicating the gallbladder location. These patients must be observed with close and regular long-term follow-up as recurrences have been reported to occur four to 7 years after surgery [10].…”

Section: Discussionmentioning

confidence: 99%

A case of inflammatory pseudotumour of the gallbladder presenting as a big mass of uncertain behavior

et al. 2020

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Background: Inflammatory pseudotumour has been used to describe an inflammatory or fibrosing tumoral process of an undetermined cause that may involve a variety of organ systems, including the lungs, spleen, liver, lymph nodes, pancreas and extrahepatic bile duct with potential for recurrence and persistent local growth. In this article, we report a patient with a big mass of uncertain nature and behavior. Case presentation: A 60-year-old woman presented with a 1-week history of abdominal pain, fever and jaundice. Six months before she had had right upper quadrant pain that was interpreted as biliary colic. A contrast-enhanced CT scan showed a big mass of soft tissue with diffuse infiltration of the gallbladder, displacement of the transverse colon, hepatic flexure and duodenum. For diagnostic distinction between a chronic inflammatory disease or a neoplasm, exploratory laparotomy was required. Intraoperative exploration disclosed a big mass of hard texture involving the gallbladder, with multiple concrements, hepatoduodenal ligament, right and transverse mesocolon, stomach and duodenum. Cholecystectomy was performed, preserving adjacent organs with macroscopic desmoplastic reaction. Histopathologic examination of the gallbladder showed a spindle cell proliferation with diffuse chronic inflammatory infiltrate of lymphocytes, plasma cells and hyalinized fibrous stroma. No vascular invasion or cellular atypia were evident. Conclusion: Inflammatory pseudotumour is a rare condition and diagnostic distinction from a chronic inflammatory disease or other neoplasm is only possible by histopathologic examination. There is a limited number of case reports in the literature indicating tumor location in the gallbladder.

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Inflammatory myofibroblastic tumor of gall bladder

Cited by 10 publications

References 3 publications

Application of 18F-FDG PET/CT imaging in gallbladder inflammatory pseudotumor with elevated CA199: a case report and review of literature

Application of 18F-FDG PET/CT imaging in gallbladder inflammatory pseudotumor with elevated CA199: a case report and review of literature

Inflammatory Myo-Fibroblastic Tumor of the Gallbladder with Multivisceral Involvement: Successful Treatment with Radical Surgery

A case of inflammatory pseudotumour of the gallbladder presenting as a big mass of uncertain behavior

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