Inflammatory Myofibroblastic Tumor of Common Bile Duct in a Girl

Wang

et al. 2023

Preprint

Introduction: Inflammatory myofibroblastic tumour of the common bile duct (CBD) is an extremely rare low-grade malignancy with various biological behaviours and a lack of specific clinical and histopathological features. Preoperative and intraoperative diagnosis are challenging, and an undiagnosed tumour can cause increased surgical trauma. Case presentation: We report a 34-year-old male who presented with yellowish whole-body skin and yellowish eyes for 20 + days. There was no history of abdominal swelling or pain, fever or chills. Computed tomography (CT) revealed a well-defined, asymmetrical, circumferential obstructing mass in the hilum-mid CBD. The patient was suspected to have cholangiocarcinoma and underwent total bile duct tumour resection and digestive tract reconstruction. The postoperative pathological diagnosis was inflammatory myofibroblastic tumour, and the patient was followed up for three years and exhibited good health. Conclusion: We report a case and literature review regarding inflammatory myofibroblastic tumour of the CBD, which is an extremely rare low-grade malignancy.

Section: Discussionmentioning

confidence: 99%

Inflammatory Myofibroblastic Tumour of the Common Bile Duct: A Case Report and Literature Review

Wang

et al. 2023

Preprint

“…IMTs seem to be more common in middle-aged women; the male-to-female ratio is 2:5, and the age range of IMT patients is 6 to 71 years (average, 46.5 years). The main clinical manifestations are jaundice without other associated symptoms, but a few patients also show abdominal pain, emaciation and fever [11,12,21]. Biliary bleeding rarely occurs [17].…”

Section: Discussionmentioning

confidence: 99%

Inflammatory myofibroblastic tumour of the common bile duct: a case report and literature review

Wang

et al. 2023

World J Surg Onc

Introduction Inflammatory myofibroblastic tumour (IMT) of the common bile duct (CBD) is an extremely rare low-grade malignancy with various biological behaviours and a lack of specific clinical and histopathological features. Preoperative and intraoperative diagnosis are challenging, and a diagnostic delay may increase surgical complexity. Case presentation We present the case of a 34-year-old male with no relevant medical history who presented with jaundice of 20 days of evolution. Histology and immunohistochemistry confirmed the diagnosis of an IMT with anaplastic lymphoma kinase (ALK)-1 expression. In addition, a review of the relevant literature revealed 13 published reports of biliary IMTs. The clinical history and histopathological features in these 13 cases were compared with those in our case to provide a comprehensive overview of the clinical manifestations and histopathological features of the disease. Conclusion IMT of the CBD is an extremely rare low-grade malignancy that mainly occurs in middle-aged female patients. The main clinical manifestation is monosymptomatic jaundice. The reported tumours originated in the middle and lower segments of the CBD, with an average size of approximately 3.5 cm × 3.0 cm and tumour cells expressing smooth muscle actin (SMA), vimentin and ALK. Abnormal ALK expression and ALK gene rearrangement represent potential histopathological and differential diagnoses. A clear diagnosis by preoperative biopsy and intraoperative frozen section examination is critical and can significantly reduce surgical trauma. The prognosis is good, and very few patients experience recurrence or distant metastasis.

Section: Discussionmentioning

confidence: 99%

Inflammatory Myofibroblastic Tumour of the Common Bile Duct: A Case Report and Literature Review

Luo

et al. 2022

Preprint

Introduction: Inflammatory myofibroblastic tumour of the common bile duct (CBD) is an extremely rare low-grade malignancy with various biological behaviours and a lack of specific clinical and histopathological features. Preoperative and intraoperative diagnosis are challenging, and an undiagnosed tumour can cause increased surgical trauma.Case presentation: We report a 34-year-old male who presented with yellowish whole-body skin and yellowish eyes for 20+ days. There was no history of abdominal swelling or pain, fever or chills. Computed tomography (CT) revealed a well-defined, asymmetrical, circumferential obstructing mass in the hilum-mid CBD. The patient was suspected to have cholangiocarcinoma and underwent total bile duct tumour resection and digestive tract reconstruction. The postoperative pathological diagnosis was inflammatory myofibroblastic tumour, and the patient was followed up for three years and exhibited good health.Conclusion: We report a case and literature review regarding inflammatory myofibroblastic tumour of the CBD, which is an extremely rare low-grade malignancy.