Inflammatory myofibroblastic tumor in children

Abstract

The authors presented the cases of two children with inflammatory myofibroblastic (IMF) tumor and reviewed the literature to facilitate the preoperative recognition, delineate the clinical features, and describe the natural history of this entity. The first child had IMF tumor arising from the mesentery of the small intestine. He presented with an abdominal mass associated with severe inflammatory response manifested by fever, impaired growth, thrombocytosis, and microcytic, hypochromic anemia. After surgical resection, his fever resolved and his growth rate and the laboratory abnormalities normalized. Five months after initial diagnosis, the fever, anemia, and thrombocytosis recurred along with two tumors arising from the omentum and the abdominal soft tissue. After the second surgery, he remains free of recurrent disease for 30 months. The second child presented with a lung mass that was radiologically indistinguishable from pulmonary sequestration. After surgical resection, she remains free of recurrent disease for 18 months. IMF tumor should be considered in any solid tumor that occurs in association with a chronic inflammatory response. IMF tumor should also be considered in the differential diagnosis of pulmonary sequestration.

Exophytic inflammatory myofibroblastic tumor of the stomach in an adult woman: A rare cause of hemoperitoneum

“…It was once accepted that IMT is primarily a disease of children and young adults and commonly occurs in the lungs [13,14] . However, a recent study by Coffin et al has shown that IMT may span the entire age range and can occur in any site of the body [1] .…”

Inflammatory pseudotumour of the sigmoid colon mesentery: US and CT findings (2004:12b)

“…However, complete surgical resection is necessary to avoid recurrence as well as to prevent [2,10,11]. The incidence of local recurrence has been reported to be 15 to 37% in IPT of the mesentery and retroperitoneum [6,13,15]. Sarcomatous transformation has also been previously reported [7,13,16].…”

Mesenteric inflammatory myofibroblastic tumors in an elder patient with early recurrence: A case report

“…In general, the most common initial symptoms and signs are palpable mass, abdominal pain, weight loss, or fever. Laboratory abnormalities are present in a minority of patients and include an elevated erythrocyte sedimentation rate (ESR), anemia, thrombocytosis, or hypergammaglobulinemia, which often resolve after resection [11][12][13][14] . Occasionally, IMT presented with symptoms like acute abdomen [10] .…”