Inflammatory myoblastic tumor of the uterus and interleukin-6

Azuno, Yoichi; Yaga, Ken; Suehiro, Yutaka; Ariyama, Shigemi; Oga, Atsunori

doi:10.1067/s0002-9378(03)00208-4

Cited by 47 publications

(39 citation statements)

References 4 publications

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“…A similar clinical presentation may be seen in the plasma cell variant of Castleman disease, in which overproduction of interleukin 6 (IL-6) is thought to be the underlying cause of the systemic complaints 22. Two patients with IMT were reported to have raised serum levels of IL-6 that returned to normal postoperatively as their systemic symptoms resolved,23 24 and several authors have demonstrated production of IL-6 mRNA and protein by tumour cells, supporting a possible analogous mechanism in IMT 23 – 25…”

Section: Clinical Featuresmentioning

confidence: 83%

Inflammatory myofibroblastic tumours: where are we now?

2007

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Inflammatory pseudotumour is a generic term applied to a variety of neoplastic and non-neoplastic entities that share a common histological appearance, namely a cytologically bland spindle cell proliferation with a prominent, usually chronic inflammatory infiltrate. Over the last two decades, inflammatory myofibroblastic tumour (IMT) has emerged from within the broad category of inflammatory pseudotumour, with distinctive clinical, pathological and molecular features. IMT shows a predilection for the visceral soft tissues of children and adolescents and has a tendency for local recurrence, but only a small risk of distant metastasis. Characteristic histological patterns include the fasciitis-like, compact spindle cell and hypocellular fibrous patterns, which are often seen in combination within the same tumour. Chromosomal translocations leading to activation of the ALK tyrosine kinase can be detected in approximately 50% of IMTs, particularly those arising in young patients. This review will examine the clinical, pathological, and molecular genetic features of IMT and discuss an approach to diagnosis and differential diagnosis.

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Section: Clinical Featuresmentioning

confidence: 83%

Inflammatory myofibroblastic tumours: where are we now?

2007

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“…IMT has been reported rarely in the uterus, cervix, or fallopian tube as individual case reports, [5][6][7] and one small series by Rabban and coworkers. 8 Most of these tumors occurred in the uterine corpus, and several presented as masses that prolapsed through the cervical os, as in our series.…”

Section: Resultsmentioning

confidence: 99%

ALK-1 Protein Expression and ALK Gene Rearrangements Aid in the Diagnosis of Inflammatory Myofibroblastic Tumors of the Female Genital Tract

Fuehrer

Keeney²,

Ketterling³

et al. 2012

Archives of Pathology &Amp; Laboratory Medicine

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Context.—Inflammatory myofibroblastic tumor is a predominantly benign, spindle cell, mesenchymal neoplasm with myxoid areas that occurs rarely in the female genital tract and may be confused with other spindle cell lesions, particularly leiomyosarcoma. Objective.—To investigate the utility of detecting anaplastic lymphoma kinase-1 protein expression and ALK gene rearrangements in the diagnosis of inflammatory myofibroblastic tumors in the female genital tract. Design.—Eight inflammatory myofibroblastic tumors arising in the female genital tract and seen in consultation (from 2004 to 2011) were reviewed. Immunohistochemistry for anaplastic lymphoma kinase-1 and fluorescence in-situ hybridization studies for ALK gene rearrangements were performed. Results.—The anatomic sites included myometrium (4 cases) and endometrium, fallopian tube, cervix, and a cervical polyp (1 each), with a patient age range from 25 to 52 years. Histologic features ranged from bland spindle cells to striking cytologic atypia, embedded in a prominent myxoid background. Anaplastic lymphoma kinase-1 immunohistochemistry was positive in 7 cases. Fluorescence in-situ hybridization studies detected ALK gene rearrangements in 5 cases. Five cases had both immunopositivity and fluorescence in-situ hybridization abnormalities, 2 cases had immunopositivity only, and 1 case was negative by both methods. Conclusions.—This is the first report, to our knowledge, of ALK gene rearrangements in inflammatory myofibroblastic tumors in the female genital tract. If a myxoid background is appreciated in a spindle cell lesion of the female genital tract, especially if inflammatory cells are present, anaplastic lymphoma kinase-1 staining along with fluorescence in situ hybridization studies, for ALK gene rearrangements, may aid in distinguishing inflammatory myofibroblastic tumors from their malignant mimics.

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“…In the gynecologic tract, it has mostly been documented in the uterus (6)(7)(8)(9)(10)(11)(12), although it has been described in extrauterine sites in the postpartum setting (13). Support for the clonal nature of this neoplasm has been furthered by the finding of chromosomal changes involving 2p23 with different fusion transcripts, including TPM3-ALK and TPM4-ALK (14)(15)(16).…”

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confidence: 99%

Inflammatory Myofibroblastic Tumor of the Placenta

Banet

Ning

Montgomery

2015

International Journal of Gynecological Pathology

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Inflammatory myofibroblastic tumor has been described in a wide variety of anatomic sites, although in the gynecologic tract, it has mostly been documented in the uterus, and has never been described in the placenta. Two patients presented with well-circumscribed placental masses that showed classic histologic features of inflammatory myofibroblastic tumor including a proliferation of myofibroblastic cells, a mixed inflammatory infiltrate, and a myxoid background. One case was positive by immunohistochemistry for anaplastic lymphoma kinase (ALK-1), whereas the other was negative by immunohistochemistry and fluorescent in situ hybridization. Inflammatory myofibroblastic tumors should be differentiated from other more aggressive uterine tumors that may involve the placenta by direct extension/metastasis because they can be managed conservatively, and in these 2 cases, did not seem to affect the course of the patient's pregnancies.

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Inflammatory myoblastic tumor of the uterus and interleukin-6

Cited by 47 publications

References 4 publications

Inflammatory myofibroblastic tumours: where are we now?

Inflammatory myofibroblastic tumours: where are we now?

ALK-1 Protein Expression and ALK Gene Rearrangements Aid in the Diagnosis of Inflammatory Myofibroblastic Tumors of the Female Genital Tract

Inflammatory Myofibroblastic Tumor of the Placenta

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