Inflammatory Monocytes Recruited to Allergic Skin Acquire an Anti-inflammatory M2 Phenotype via Basophil-Derived Interleukin-4

Egawa, Mayumi; Mukai, Kaori; Yoshikawa, Seiji; Iki, Misako; Mukaida, Naofumi; Kawano, Yoshiaki; Minegishi, Yoshiyuki; Karasuyama, Hajime

doi:10.1016/j.immuni.2012.11.014

Cited by 223 publications

(220 citation statements)

References 65 publications

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“…In addition, release of IL-4 and IL-13 by basophils may induce alternatively activated macrophages, which in turn play a role in tissue homeostasis and repair [40,41]. Therefore, synergy in cytokine production by basophils may amplify Th2-type immune responses via T cell-dependent and -independent mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Activation of human basophils by combined toll‐like receptor‐ and FcεRI‐triggering can promote Th2 skewing of naive T helper cells

et al. 2013

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Additional supporting information may be found in the online version of this article at the publisher's web-site IntroductionBasophils are circulating granulocytes that can migrate to tissues when inflammation or other triggers are present locally. Activation of basophils through crosslinking of FcεRI via antigen-specific IgE causes the release of granule contents (histamine, proteoglycans), lipid-derived mediators (leukotrienes), and cytokines. Due to their potent activation via IgE-bound antigens and their production of T helper 2 (Th2) type cytokines such as IL-4 and IL-13, Correspondence: Jolien Suurmond e-mail: j.suurmond@lumc.nl basophils are often considered important innate effector cells in IgE-mediated immune responses. Besides activation through IgE, several other pathways have been described to activate basophils, including activation through complement receptors and toll-like receptors (TLR). Although information about TLR protein expression and the response of basophils to TLR ligands is scarce, human basophils express mRNA of several TLRs, and protein of TLR-2 and -4. However, the functional response of basophils to ligation of most TLRs is unknown [1][2][3][4].Basophil responses to TLR ligands may be important, as it is not understood how pathogens and allergens may lead to induction of Th2 responses. As TLR ligation of dendritic cells most often induces type 1 responses through production of IL-12, it is not understood whether and how Th2 cells can be induced via TLR. Since basophils are a known early source of IL-4 and other cytokines associated with Th2 responses, they have been proposed to play a prominent role in the induction of such responses [8]. In mice, it was suggested that basophils play a crucial role in responses against Th2-associated helminth parasites and in protease allergens [9][10][11]. Basophils were proposed to function as APCs in these studies and were also shown to be present in LNs in models of allergy and helminth infection [12][13][14]. However, the function of basophils as APCs during the priming phase of Th2 responses in mice has been challenged by others [13,15,16], and human basophils could not present antigens to CD4 + T cells [17,18]. Therefore, it seems unlikely that human basophils function as APCs. However, by providing an early IL-4 signal that facilitates Th2 skewing after T-cell activation by APCs, basophils could play an important role in skewing of Th2 responses as accessory cells. Indeed, in a mouse model for papain-induced Th2 responses, both DCs and basophils were important for Th2 skewing [19].Since several allergens and helminth parasites can activate TLRs [20][21][22], it would be of high importance to know whether human basophils can be activated via TLR triggering, and if so, which cytokines are released. Until now, little information on these aspects is available for human basophils. Furthermore, as allergic responses and helminth infections may induce IgE responses [23], it would be important to know whether these pathways would interact and prom...

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Section: Discussionmentioning

confidence: 99%

Activation of human basophils by combined toll‐like receptor‐ and FcεRI‐triggering can promote Th2 skewing of naive T helper cells

et al. 2013

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“…Over the past years several genetic mouse models have been used to elucidate basophil functions in vivo. It has been shown that basophils cooperate with dendritic cells to initiate Th2 responses, promote alternative activation of macrophages, and contribute to acquired resistance against parasites (12)(13)(14)(15)(16). We and others have shown that basophils contribute to protective immune responses against secondary infection by Nb and ticks (13,14,17).…”

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confidence: 85%

Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion

Schwartz

Turqueti-Neves

Hartmann

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Significance Gastrointestinal worms (helminths) infect more than 2 billion people, and vaccines are not yet available. Helminths elicit a type 2 immune response characterized by high serum IgE levels and increased numbers of IL-4– or IL-13–secreting effector cells including Th2 cells, eosinophils, basophils, and type 2 innate lymphoid cells. We determined the mechanism by which basophils contribute to protection against secondary infections with gastrointestinal helminths. Here we demonstrate that basophils are recruited into the small intestine of infected mice and orchestrate the local type 2 immune response in this tissue. Basophil-mediated protection required the presence of IgE and the expression of activating Fc receptors and IL-4/IL-13 in basophils. These findings could help the development of new vaccination strategies against helminths.

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“…On the other hand, an unexpected interaction between basophils and monocytes-macrophages was observed during allergic skin inflammation [22]. The fate, polarization and function of monocytes after their recruitment to skin lesions were analyzed under an immunoglobulin Emediated chronic allergic inflammation (IgE-CAI), a model where basophils play a critical role.…”

Section: Basophils and Th2 Cell Responsesmentioning

confidence: 99%

The role of eosinophils and basophils in allergic diseases considering genetic findings

Nadif

Zerimech²,

Matran³

2013

Current Opinion in Allergy &Amp; Clinical Immunology

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2 Purpose of reviewBasophils and eosinophils respectively represent less than 1 and 5% of white blood cells respectively. Their role in asthma and allergic inflammation remains incompletely defined.The present review addresses recent advances regarding the role of these two cell populations in allergic inflammation and asthma regarding both biological and genetic point of view. Recent findingsRegarding eosinophils, the role of interleukin ( SummaryRecent findings from biological and genetic studies on eosinophils and basophils highlight the role of epithelial cell-derived cytokines such as TSLP and IL-33 in asthma and allergic diseases.

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Inflammatory Monocytes Recruited to Allergic Skin Acquire an Anti-inflammatory M2 Phenotype via Basophil-Derived Interleukin-4

Cited by 223 publications

References 65 publications

Activation of human basophils by combined toll‐like receptor‐ and FcεRI‐triggering can promote Th2 skewing of naive T helper cells

Activation of human basophils by combined toll‐like receptor‐ and FcεRI‐triggering can promote Th2 skewing of naive T helper cells

Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion

The role of eosinophils and basophils in allergic diseases considering genetic findings

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