Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: A Systematic Review

Magalhães, Rafael Coelho; Pimenta, Leticia Pretti; Barbosa, Izabela Guimarães; Moreira, Janaína Matos; Barros, João Luís Vieira Monteiro de; Teixeira, Antônio Lúcio; Silva, Ana Cristina Simões e

doi:10.1016/j.ijdevneu.2017.10.006

Cited by 11 publications

(4 citation statements)

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“…Older demented patients with worse cognitive function show higher levels of inflammation [ 13 ] and inflammation plays a critical role in the pathological process of mild cognitive impairment [ 41 ]. In addition, cytokines and chemokines have been previously demonstrated to play a role in cognitive development [ 28 ]. In agreement with this hypothesis, in a previous study we observed that the systemic inflammation index influence verbal memory, verbal fluency, speed of information processing, and psychomotor coordination [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Long-term consequences of COVID-19 on cognitive functioning up to 6 months after discharge: role of depression and impact on quality of life

Poletti

Palladini

Mazza

et al. 2021

Eur Arch Psychiatry Clin Neurosci

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Neurologic and psychiatric symptoms have been reported in the months following the infection with COVID-19. A low-grade inflammation has been associated both with depression and cognitive symptoms, suggesting a link between these disorders. The aim of the study is to investigate cognitive functioning 6 months following hospital discharge for COVID-19, the impact of depression, and the consequences on quality of life. Ninety-two COVID-19 survivors evaluated at 1-month follow-up, 122 evaluated at 3 months and 98 evaluated at 6 months performed neuropsychological and psychiatric evaluations and were compared with a healthy comparison group (HC) of 165 subjects and 165 patients with major depression (MDD). Cognitive performances were adjusted for age, sex, and education. Seventy-nine percent of COVID-19 survivors at 1 month and 75% at 3- and 6-month follow-up showed cognitive impairment in at least one cognitive function. No significant difference in cognitive performances was observed between 1-, 3-, and 6-months follow-up. COVID-19 patients performed worse than HC but better than MDD in psychomotor coordination and speed of information processing. No difference between COVID-19 survivors and MDD was observed for verbal fluency, and executive functions, which were lower than in HC. Finally, COVID-19 survivors performed the same as HC in working memory and verbal memory. The factor that most affected cognitive performance was depressive psychopathology which, in turn, interact with cognitive functions in determining quality of life. Our results confirm that COVID-19 sequelae include signs of cognitive impairment which persist up to 6 months after hospital discharge and affect quality of life. Supplementary Information The online version contains supplementary material available at 10.1007/s00406-021-01346-9.

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Section: Discussionmentioning

confidence: 99%

Long-term consequences of COVID-19 on cognitive functioning up to 6 months after discharge: role of depression and impact on quality of life

Poletti

Palladini

Mazza

et al. 2021

Eur Arch Psychiatry Clin Neurosci

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“…Plenty of studies have shown that inflammation activation leads to cognitive deficits, suggesting a prominent role of IL-1β, IL-6, IL-18, and TNF-α (Duarte et al, 2017;Magalhaes et al, 2018;Shen et al, 2019;Chakrabarty, Torres, Bond, & Yatham, 2019). On the other hand, Neurocognitive impairments are common in patients with viral infections because inflammation may also be present after clearing the virus (Peiris et al, 2003).…”

Section: Cognitive Functions After Cytokine Storm In Covid-19mentioning

confidence: 99%

Probable Neuropsychological and Cognitive Complications Due to Cytokine Storm in Patients With COVID-19

Keshtgar

Chalabianloo

Esmaeili

2023

BCN

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Introduction: COVID-19 (coronavirus disease 2019) was identified in China in December 2019 for the first time and is rapidly spreading throughout the world as a pandemic. As COVID-19 causes mild to severe acute respiratory syndrome, most studies in this context have focused on pathogenesis primarily in the respiratory system. However, evidence shows that the central nervous system (CNS) may also be affected by COVID-19. Since COVID-19 is spreading, it is imperative to study its possible cognitive effects in patients suffering and recovering from COVID-19. Methods: The articles used in this study were searched by keywords such as Cytokine storm and covid-19, covid-19 and executive dysfunction, cognitive disorder and covid-19, CNS and covid 19, Coronavirus, Neuroinvasion in science direct, Scopus, PubMed, Embase, and Web of Science databases based on Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) checklist. The study will assess all observational studies published between December 2019 and April 2021 in peer-reviewed journals, including cross-sectional, cohort, case-control studies, case reports and case series. The search result was 106 articles, of which 73 articles related to Covid-19, the stages of infection by this virus, its effect on the nervous system and neurological symptoms, the cytokine storm caused by this infection, and the possible cognitive consequences caused by this virus in patients, has been reviewed. Other articles were not checked due to their limited relevance to the topic under discussion. Results: Studies show that neurons may be directly affected by SARS-CoV-1 and SARS-CoV-2. Furthermore, various studies indicate that systemic inflammation (so-called "cytokine storm") is also responsible for brain damage induced by infection with SARS-CoV-1 and SARS-CoV-2. Such a way that this patients showed elevated levels of interleukin (IL-), 6, 8, and 10 and of tumor necrosis factor-alpha (TNF- α) in their blood. Conclusion: Various cognitive defects following an increase level of cytokines such as TNF-α and IL-6,8 have been observed. Therefore, due to the increase level of these pro-inflammatory factors in the brains of these patients, cognitive deficits can be expected, which need further investigation.

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“…The 2021 Delgado-Alonso study examined 50 patients who underwent COVID-19, and they performed worse than healthy subjects in areas such as divided attention, selective attention, executive function, visuospatial processing, working memory and episodic memory [57]. The genesis of cognitive problems is not fully understood, but there are several hypotheses according to which cognitive dysfunction may, among other things, result from: direct invasion of the brain centers in question by the virus; from hypoxia resulting from the virus invading the lungs and bronchi, and subsequently the brain; from stroke and meningitis; from inflammation due to SARS-CoV-2 virus infection [58,59,60,61]. Among those infected with the virus, inflammatory changes in blood vessels and arteriovenous problems can occur, which can impinge on the occurrence of cognitive dysfunction [62].…”

Section: Sars-cov-2 As a Neuroinvasive Neurotropic And Neurovirulent ...mentioning

confidence: 99%

COVID-19 pandemic: disease impact on nervous system, cognitive functioning and mental health

Janeczek

2022

J Educ Health Sport

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Introduction and purpose:COVID-19, as an unknown disease until 2019, has posed and continues to pose a great challenge to the world of science and the people facing it. The purpose of this article is to present the possible consequences of experiencing COVID-19 disease and the pandemic itself in light of mental health and the organism functioning in the cognitive area, taking into account the impact of COVID-19 on the nervous system.State of knowledge (brief description):Coronaviruses are enveloped, positive single-stranded large RNA viruses. COVID-19 is a disease caused by the SARS-CoV-2 virus – its first case was reported in 2019 in Wuhan, China. Human coronaviruses can exhibit neuroinvasive, neurotropic and neurovirulent, SARS-CoV-2 also. In addition to symptoms and complications in the respiratory system, symptoms and complications are also encountered in the nervous system area; cognitive functioning may also be impaired. The pandemic as a phenomenon in itself and the outbreak of COVID-19 can carry very serious consequences from the mental health field. Among these are the problem of social isolation and its consequences or the impact of the disease and pandemic on well-being. Unfortunately, the time that has elapsed since the first cases of the disease and the amount of research does not allow a clear determination of the complications and consequences of the pandemic, but certain trends and phenomena are regularly studied and described.Summary:Existing research and the state of the art strongly underscore that COVID-19 and its pandemic could impinge on the mental health of people around the world. Changes in the nervous system and cognitive functioning are also observed as a result of contracting COVID-19. Science currently has no clear answers as to how long certain complications will persist and exactly what their genesis is – further research is recommended to explain them as precisely as possible.

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Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: A Systematic Review

Abstract: There is preliminary evidence indicating that circulating inflammatory molecules are associated with motor and cognitive development in preterm neonates, even considering different populations.

Cited by 11 publications

References 74 publications

Long-term consequences of COVID-19 on cognitive functioning up to 6 months after discharge: role of depression and impact on quality of life

Long-term consequences of COVID-19 on cognitive functioning up to 6 months after discharge: role of depression and impact on quality of life

Probable Neuropsychological and Cognitive Complications Due to Cytokine Storm in Patients With COVID-19

COVID-19 pandemic: disease impact on nervous system, cognitive functioning and mental health

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