Inflammatory Metastatic Carcinoma

Hazelrigg, Donald E.

doi:10.1001/archderm.1977.01640010071012

Cited by 65 publications

(17 citation statements)

References 5 publications

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“…Cutaneous infiltration accompanying melanoma was seen in 15.5% of patients, while skin involvement with other types of primary tumours, such as those described in this paper, were much more rare. Tumours associated with other inflammatory skin metastases are anal tumours (Meadows & Egan 1999), lung or bronchial carcinoma (Hazelrigg & Rudolph 1977;Homler et al 1986), melanoma (Lindmaier & Wolfgang 1990;Böni et al 1997;Ozkan et al 1999), gastric cancer (Hariri et al 2000), pancreatic carcinoma, rectal carcinoma, ovarian/cervical carcinoma and parotid gland tumours. Cutaneous metastases often present as firm, discrete, reddish nodules.…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

Cancer-related secondary lymphoedema due to cutaneous lymphangitis carcinomatosa: clinical presentations and review of literature

Damstra

Jagtman

Steijlen

2009

European Journal of Cancer Care

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Lymphoedema is a clinical condition caused by impairment of the lymphatic system, leading to swelling of subcutaneous soft tissues. As a result, accumulation of protein-rich interstitial fluid and lymphostasis often causes additional swelling, fibrosis and adipose tissue hypertrophy leading to progressive morbidity and loss of quality of life for the patient. Lymphoedema can be distinguished as primary or secondary. Lymphoedema is a complication frequently encountered in patients treated for cancer, especially after lymphadenoectomy and/or radiotherapy based on destruction of lymphatics. However, although lymphatic impairment is sometimes caused by obstructive solid metastasis, we present three cases of secondary lymphoedema with minor dermatological features without detectable solid metastasis. Sometimes this type of lymphoedema is mistakenly called malignant lymphoedema. All patients were previously treated for cancer without clinical signs of recurrence, presented with progressive lymphoedema and minor dermatological features of unknown origin. Clinical and histopathological examination of the skin revealed diffuse lymphangitis carcinomatosa, leading to secondary lymphoedema and adjustment of the therapeutic approach and prognosis. We reviewed literature on these rare presentations of cancer recurrence and recommend, where appropriate, consulting a dermatologist when discrete skin abnormalities are seen in patients with a history of cancer and developing lymphoedema.

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Section: Discussion and Review Of Literaturementioning

confidence: 99%

Cancer-related secondary lymphoedema due to cutaneous lymphangitis carcinomatosa: clinical presentations and review of literature

Damstra

Jagtman

Steijlen

2009

European Journal of Cancer Care

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“…In the present patient, an infectious process was considered, but the clinical picture and history did not completely support this diagnosis. In general, specific clinical features such as lack of a febrile response, absence of leukocytosis and prolonged presence of the lesion (weeks to months) without response to antibiotics should alert the physician to the possibility of cutaneous metastasis (8).…”

Section: Discussionmentioning

confidence: 99%

“…These skin changes, characterized by red induration with distinctly marginated borders associated with skin metastases, were later described as "carcinoma erysipelatoides" by Rasch in 1931 (10) for their similarity to the infectious skin condition erysipelas (Figure 3). Thus, both terms, inflammatory carcinoma and carcinoma erysipeloides, have been used interchangeably when describing skin metastases with inflammatory skin changes and histological invasion of dermal lymphatics (6,8,(11)(12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

Metastatic cutaneous breast carcinoma: A case report and review of the literature

Nava¹,

Greer²,

Patterson³

et al. 2009

CAN J PLAST SURG

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Cutaneous metastatic carcinoma, also known as carcinoma erysipeloides, is an unusual clinical finding. In women, it is most frequently found in association with breast cancer rather than other visceral malignancies. Breast cancer patients can present with cutaneous manifestations of breast disease at the time of their initial diagnosis; however, cutaneous metastases more often present well after the initial diagnosis and treatment of the breast disease. Prompt recognition of skin metastases by the plastic surgeon, especially during the delayed setting of reconstructive surgery following mastectomy, allows for earlier intervention in treating the systemic spread of the disease. A clinical case of carcinoma erysipeloides presenting in this delayed setting is outlined in the present report, along with a review of the literature. Key Words: Breast cancer; Carcinoma erysipeloides; Cutaneous metastasesUn carcinome cutané métastatique du sein : Un rapport de cas et une analyse bibliographiqueLe carcinome cutané métastatique, ou carcinome érysipéloïde, est une observation clinique inhabituelle. Chez les femmes, il s'associe plutôt au cancer du sein qu'aux autres tumeurs malignes viscérales. Les patientes atteintes du cancer du sein peuvent présenter des manifestations cutanées de ce cancer au moment du diagnostic. Cependant, les métastases cutanées font beaucoup plus souvent leur apparition bien après le diagnostic initial et le traitement de la maladie cancéreuse. Un dépistage rapide des métastases cutanées par le chirurgien plastique, notamment dans le cadre reporté de la chirurgie reconstructive après une mastectomie, permet une intervention plus rapide pour éviter la propagation systémique de la maladie. Le présent rapport expose un cas clinique de carcinome érysi-péloïde, de même qu'une analyse bibliographique dans un tel contexte. C utaneous metastatic carcinoma is an unusual clinical finding. Review of the literature indicates that the incidence of cutaneous metastases for all types of carcinomas ranges from 0.7% to 10.0% (1-3). Similarly, a more recent meta-analysis (4) demonstrated the overall incidence to be closer to 5.3%. Metastatic cutaneous lesions are more often found in women with breast cancer, than in those with other visceral malignancies, with an incidence exceeding 20% (3-6). Often, the cutaneous lesions do not become apparent until quite some time has passed from the initial treatment of the original carcinoma.

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“…4,84 It seems that oat-cell carcinomas have a predilection for the back. Rare clinicopathologic variants include lesions with zosteriform pattern, 6,80 metastatic inflammatory carcinoma, 85 and telangiectatic metastatic lung carcinoma on the axilla and chest with neoplastic emboli within dilated lymphatic vessels of he dermis. 6 Most patients have a localized cluster of cutaneous nodules.…”

Section: Cutaneous Metastases From Lung Cancermentioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

218

104

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Skin metastases occur in 0.6%-10.4% of all patients with cancer and represent 2% of all skin tumors. Skin metastases from visceral malignancies are important for dermatologists and dermatopathologists because of their variable clinical appearance and presentation, frequent delay and failure in their diagnosis, relative proportion of different internal malignancies metastasizing to the skin, and impact on morbidity, prognosis, and treatment. Another factor to take into account is that cutaneous metastasis may be the first sign of clinically silent visceral cancer. The relative frequencies of metastatic skin disease tend to correlate with the frequency of the different types of primary cancer in each sex. Thus, women with skin metastases have the following distribution in decreasing order of frequency of primary malignancies: breast, ovary, oral cavity, lung, and large intestine. In men, the distribution is as follows: lung, large intestine, oral cavity, kidney, breast, esophagus, pancreas, stomach, and liver. A wide morphologic spectrum of clinical appearances has been described in cutaneous metastases. This variable clinical morphology included nodules, papules, plaques, tumors, and ulcers. From a histopathologic point of view, there are 4 main morphologic patterns of cutaneous metastases involving the dermis, namely, nodular, infiltrative, diffuse, and intravascular. Generally, cutaneous metastases herald a poor prognosis. The average survival time of patients with skin metastases is a few months. In this article, we review the clinicopathologic and immunohistochemical characteristics of cutaneous metastases from internal malignancies, classify the most common cutaneous metastases, and identify studies that may assist in diagnosing the origin of a cutaneous metastasis.

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Inflammatory Metastatic Carcinoma

Cited by 65 publications

References 5 publications

Cancer-related secondary lymphoedema due to cutaneous lymphangitis carcinomatosa: clinical presentations and review of literature

Cancer-related secondary lymphoedema due to cutaneous lymphangitis carcinomatosa: clinical presentations and review of literature

Metastatic cutaneous breast carcinoma: A case report and review of the literature

Cutaneous Metastases From Internal Malignancies

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