Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy

Vásquez-Procopio, Johana; Espejel-Núñez, Aurora; Torres-Torres, Johnatan; Martinez‐Portilla, R.J.; Sosa, Salvador Espino Y; Mateu-Rogell, Paloma; Ortega-Castillo, Veronica; Tolentino-Dolores, Maricruz; Perichart-Perera, Otilia; Franco-Gallardo, José Osman; Carranco-Martínez, José Alberto; Prieto-Rodríguez, Scarleth; Guzmán-Huerta, Mario; Missirlis, Fanis; Estrada-Gutiérrez, Guadalupe

doi:10.3389/fcell.2022.935363

Cited by 2 publications

(2 citation statements)

References 108 publications

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“…COVID-19 infection has a negative impact on the cytokine profile of pregnant women, varying according to the trimesters of pregnancy ( 18 ). Increased levels of cytokines, mainly proinflammatory cytokines, are correlated with the severity of the disease and predispose to miscarriage or premature birth ( 19 , 20 ).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of IL-6 signaling prevents serum-induced umbilical cord artery dysfunction from patients with severe COVID-19

Almeida

Lima

Machado

et al. 2023

American Journal of Physiology-Regulatory, Integrative and Comp

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Coronavirus disease 2019 (COVID-19) infection has a negative impact on the cytokine profile of pregnant women. Increased levels of pro-inflammatory cytokines seem to be correlated with the severity of the disease, in addition to predisposing to miscarriage or premature birth. Pro-inflammatory cytokines increase the generation of reactive oxygen species (ROS). It is unclear how interleukin-6 (IL-6) found in the circulation of severe COVID-19 patients might affect gestational health, particularly concerning umbilical cord function. This study tested the hypothesis that IL-6 present in the circulation of women with severe COVID-19 causes umbilical cord artery dysfunction by increasing ROS generation and activating redox-sensitive proteins. Umbilical cord arteries were incubated with serum from healthy women and women with severe COVID-19. Vascular function was assessed using concentration-effect curves to serotonin in the presence or absence of pharmacological agents, such as tocilizumab (antibody against the IL-6 receptor), tiron (ROS scavenger), ML171 (Nox1 inhibitor), and Y27632 (Rho kinase inhibitor). ROS generation was assessed by the dihydroethidine probe and Rho kinase activity by an enzymatic assay. Umbilical arteries exposed to serum from women with severe COVID-19 were hyperreactive to serotonin. This effect was abolished in the presence of tocilizumab, tiron, ML171, and Y27632. In addition, serum from women with severe COVID-19 increased Nox1-dependent ROS generation and Rho kinase activity. Increased Rho kinase activity was abolished by tocilizumab and tiron. Serum cytokines in women with severe COVID-19 promote umbilical artery dysfunction. IL-6 is key to Nox-linked vascular oxidative stress and activation of the Rho kinase pathway.

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Section: Introductionmentioning

confidence: 99%

Inhibition of IL-6 signaling prevents serum-induced umbilical cord artery dysfunction from patients with severe COVID-19

Almeida

Lima

Machado

et al. 2023

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…Pregnant women present changes in the immune system; therefore, they are generally considered vulnerable to infectious diseases [ 5 , 6 ]. Several studies have reported that pregnant women who experienced severe symptoms of COVID-19 were at higher risk for cesarean delivery, postpartum hemorrhage, hypertensive disorders of pregnancy, preterm birth, and maternal death [ 7 , 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women

Vásquez-Procopio

Torres-Torres

Borboa-Olivares

et al. 2022

IJMS

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Evidence from studies in the general population suggests an association between vitamin D insufficiency/deficiency and COVID-19 susceptibility and disease severity. The present study was performed on 165 third-trimester pregnant women at the time of delivery. Seventy-nine women tested negative for SARS-CoV-2. From 86 women testing positive, 32 were asymptomatic, 44 presented a mild form of the disease, and 10 experienced severe symptoms. Serum 25-OH vitamin D levels were measured on blood samples collected on admission. Low vitamin D levels were detected in symptomatic but not asymptomatic COVID-19 patients compared to healthy women (p = 0.0227). In addition, 20 (45.4%) pregnant women in the mild COVID-19 group and 6 (60%) in the severe group were vitamin D deficient (p = 0.030). On the other hand, lasso regression analysis showed that 25-OH vitamin D deficiency is an independent predictor of severe COVID-19 with an odds ratio (OR) of 5.81 (95% CI: 1.108–30.541; p = 0.037). These results show the relationship between vitamin D deficiency in pregnant women and the severity of COVID-19 infection and support the recommendation to supplement with vitamin D to avoid worse COVID-19 outcomes during pregnancy.

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Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy

Cited by 2 publications

References 108 publications

Inhibition of IL-6 signaling prevents serum-induced umbilical cord artery dysfunction from patients with severe COVID-19

Inhibition of IL-6 signaling prevents serum-induced umbilical cord artery dysfunction from patients with severe COVID-19

Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women

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