Inflammatory mediators involved in the progression of the metabolic syndrome

Ma, Kuifen; Jin, Xi; Liang, Xiaoyang; Zhao, Qiu; Zhang, Xingguo

doi:10.1002/dmrr.2291

Cited by 20 publications

(19 citation statements)

References 89 publications

(96 reference statements)

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“…High-sensitivity C reactive protein (hsCRP) was measured by nephelometry on an IMMAGE analyser (Beckman-Coulter, Villepinte, France). We measured plasma levels of high-sensitive interleukin 6 level, reflecting global inflammation and ageing, soluble CD14 (sCD14) and soluble CD163 (sCD163) (Quantikine ELISA Kit, R&D Systems, Oxford, UK), two markers of monocyte/macrophage activation involved in HIV-related chronic immune activation,37 and leptin (Quantikine; R&D Systems, Oxford, UK) and total adiponectin (ALPCO, EUROBIO, Les Ulis, France), two adipokines involved in MetS38 39 and OA 40…”

Section: Methodsmentioning

confidence: 99%

Increased prevalence and severity of radiographic hand osteoarthritis in patients with HIV-1 infection associated with metabolic syndrome: data from the cross-sectional METAFIB-OA study

et al. 2016

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Objective To determine radiographic hand osteoarthritis (HOA) prevalence in patients with HIV-1 infection in comparison with the general population and to address whether metabolic syndrome (MetS) may increase the risk of HOA during HIV-1 infection. Patients Patients with HIV-1 infection and MetS (International Diabetes Federation, IDF criteria) aged 45–65 years were matched by age and gender to HIV-1-infected subjects without MetS and underwent hand radiographs. Framingham OA cohort was used as general population cohort. Methods Radiographic HOA was defined as Kellgren–Lawrence (KL) score ≥2 on more than one joint. Radiographic severity was assessed by global KL score and number of OA joints. HOA prevalence was compared with that found in the Framingham study, stratified by age and sex. Logistic and linear regression models were used to determine the risk factors of HOA in patients with HIV-1 infection. Results 301 patients (88% male, mean age 53.4 ±5.0 years) were included, 152 with MetS and 149 without it. Overall, HOA prevalence was 55.5% and was higher for those with MetS than those without it (64.5% vs 46.3%, p=0.002). When considering men within each age group, HOA frequency was greater in patients with HIV-1 infection than the general population (all ages: 55.8% vs 38.7%; p<0.0001), due to the subgroup with MetS (64.9%; p<0.0001), as well as the subgroup without MetS, although not significant (46.6%; p=0.09). Risk of HOA was increased with MetS (OR 2.23, 95% 95% CI 1.26% to 3.96%) and age (OR 1.18, 95% CI 1.12 to 1.25). HOA severity was greater for patients with MetS than those without. HOA was not associated with previous or current exposure to protease inhibitors or HIV infection-related markers. Conclusions HOA frequency is greater in patients with HIV-1 infection, especially those with MetS, than the general population.

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Section: Methodsmentioning

confidence: 99%

Increased prevalence and severity of radiographic hand osteoarthritis in patients with HIV-1 infection associated with metabolic syndrome: data from the cross-sectional METAFIB-OA study

et al. 2016

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“…Leptin, resistin, and adiponectin originate predominately in adipose tissue (Rajala and Scherer 2003; Klempel and Varady 2011) and are known to contribute to the inflammatory milieu (Ma et al. 2012). While leptin and resistin are positively correlated with body mass index (Friedman 2002; Pagano et al.…”

Section: Discussionmentioning

confidence: 99%

An energy‐reduced dietary pattern, including moderate protein and increased nonfat dairy intake combined with walking promotes beneficial body composition and metabolic changes in women with excess adiposity: a randomized comparative trial

Shlisky¹,

Durward

Zack

et al. 2015

Food Science & Nutrition

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Moderate protein and nonfat dairy intake within an energy-reduced diet (ERD) may contribute to health benefits achieved with body weight (BW) loss. The current study examined the effectiveness of a weight-loss/weight-loss maintenance intervention using an ERD with moderate dietary protein (30% of kcals) and increased nonfat dairy intake (4–5 svg/d), including yogurt (INT group) and daily walking compared to an ERD with standard protein (16–17% of kcals) and standard nonfat dairy intake (3 svg/d) (COM group) with daily walking. A randomized comparative trial with 104 healthy premenopausal women with overweight/obesity was conducted in a university setting. Women were randomized to INT group or COM group. Anthropometric measurements, as well as dietary intake, selected vital signs, resting energy expenditure, blood lipids, glucose, insulin, and selected adipose-derived hormones were measured at baseline, and weeks 2, 12, and 24. Targets for dietary protein and nonfat dairy intake, while initially achieved, were not sustained in the INT group. There were no significant effects of diet group on anthropometric measurements. Women in the INT group and COM group, respectively, reduced BW (−4.9 ± 3.2 and −4.3 ± 3.3 kg, P < 0.001) and fat mass (−3.0 ± 2.2 and −2.3 ± 2.3 kg, P < 0.001) during the 12-week weight-loss phase and maintained these losses at 24 weeks. Both groups experienced significant decreases in body mass index, fat-free soft tissue mass, body fat percentage, waist and hip circumferences and serum triglycerides, total cholesterol, and leptin (all P < 0.001). Healthy premenopausal women with excess adiposity effectively lost BW and fat mass and improved some metabolic risk factors following an ERD with approximately 20% protein and 3 svg/d of nonfat dairy intake.

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“…Treatment of celecoxib was then stopped, and the FBG levels rebounded to 6.9±0.4 and 7.1±0.1 mmol/l in approximately 3 days, respectively. Nevertheless, the influence (Table 3) [13][14][15]. We found that 238 differentially expressed secretory genes were inflammatory mediators and the number was about half that of the differentially expressed secretory genes (ESM Table 4).…”

Section: An Inflammatory Mediator Of Inflammation (Tnfsf13) Is Correlmentioning

confidence: 95%

Analysis of global gene expression profiles suggests a role of acute inflammation in type 3C diabetes mellitus caused by pancreatic ductal adenocarcinoma

Gao

Zhou

et al. 2015

Diabetologia

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Aims/hypothesis Pancreatic ductal adenocarcinoma (PDAC) can cause type 3C diabetes, known as PDAC-associated diabetes mellitus (PDAC-DM), but the mechanism is unknown. This study aimed to reveal the mechanism. Methods PDAC lesions from patients with or without PDAC-DM (n=4 in each group) were individually profiled for 23,512 mRNAs with microarrays. Bioinformatic analysis and in vivo and in vitro assays were then conducted. Results We determined that 2,778 genes were differentially expressed; over-representation of ten genes was validated with quantitative RT-PCR. The analysis of gene ontology showed that the differentially expressed secretory genes were related mainly to inflammation. High levels of a marker of inflammation (C-reactive protein [CRP]) and an inflammatory mediator (TNF super-family member 13 [TNFSF13]) were found in the serum of patients with PDAC-DM. After surgical resection of PDAC lesions, CRP and TNFSF13 levels significantly decreased (p<0.01). Furthermore, we found that the levels of TNFSF13 in PDAC lesions and TNFSF13 and CRP in serum were significantly correlated with the diabetic status of patients with PDAC-DM (p<0.01). Assays in vivo showed that after exposure to an inhibitor of inflammation (celecoxib), the fasting blood glucose level in the mouse model of PDACWenchao Gao, Yu Zhou and Qingyan Li contributed equally to this work Electronic supplementary material The online version of this article

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Inflammatory mediators involved in the progression of the metabolic syndrome

Cited by 20 publications

References 89 publications

Increased prevalence and severity of radiographic hand osteoarthritis in patients with HIV-1 infection associated with metabolic syndrome: data from the cross-sectional METAFIB-OA study

Increased prevalence and severity of radiographic hand osteoarthritis in patients with HIV-1 infection associated with metabolic syndrome: data from the cross-sectional METAFIB-OA study

An energy‐reduced dietary pattern, including moderate protein and increased nonfat dairy intake combined with walking promotes beneficial body composition and metabolic changes in women with excess adiposity: a randomized comparative trial

Analysis of global gene expression profiles suggests a role of acute inflammation in type 3C diabetes mellitus caused by pancreatic ductal adenocarcinoma

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