Inflammatory Mediators in Exhaled Breath Condensate of Children With Obstructive Sleep Apnea Syndrome

Goldbart, Aviv; Krishna, Jyoti; Li, Richard; Serpero, Laura D.; Gozal, David

doi:10.1378/chest.130.1.143

Cited by 160 publications

(103 citation statements)

References 42 publications

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“…4,[23][24] The results we observed in our study are consistent with the current evidence showing elevated cytokines and inflammatory markers in exhaled breath as well as upper airway tissues of OSA patients. 4,[9][10][11][12][13][14][15][16][17]23,[25][26][27][28] Salerno et al and Devouassoux et al detected increased neutrophils and reduced macrophages in the induced sputum of OSA patients. 27,28 The latter study also observed a concurrent higher interleukin-8 concentration in the induced sputum specimen of these patients.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Continuous Positive Airway Pressure Therapy Normalizes High Exhaled Nitric Oxide Levels in Obstructive Sleep Apnea

Chua

Aboussouan

Minai

et al. 2013

Journal of Clinical Sleep Medicine

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Section: Discussionmentioning

confidence: 99%

Long-Term Continuous Positive Airway Pressure Therapy Normalizes High Exhaled Nitric Oxide Levels in Obstructive Sleep Apnea

Chua

Aboussouan

Minai

et al. 2013

Journal of Clinical Sleep Medicine

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“…It has now become apparent that both nasal and oropharyngeal mucosal inflammation are present in children with OSA, and may contribute to increased adenotonsillar proliferation in children with OSA [8]. The recently reported increase in the expression of glucocorticoid receptors in upper airway lymphoid tissues would globally predict favourable outcomes when using intranasal corticosteroids (CS) in paediatric OSA [9], and indeed intranasal CS have shown promising efficacy in reducing the size of the upper airway lymphoid tissues [10][11][12][13][14].…”

mentioning

confidence: 99%

Corticosteroids suppress in vitro tonsillar proliferation in children with obstructive sleep apnoea

Kheirandish‐Gozal¹,

Serpero²,

Dayyat³

et al. 2008

European Respiratory Journal

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Intranasal corticosteroids (CS) are potentially useful interventions for children with obstructive sleep apnoea (OSA), and may reduce lymphadenoid tissue size in the upper airway. The present authors hypothesised that CS would reduce cellular proliferation and the production of pro-inflammatory cytokines in a tonsil/adenoid mixed-cell culture system. Dissociated tonsils or adenoids harvested intra-operatively from children with polysomnographically diagnosed OSA were cultured in control medium (CO) or after stimulation with lipopolysaccharide and concanavalin A (STIM), and incubated with dexamethasone (DEX; 10 ; n554). DEX, FLU and BUD reduced cellular proliferation rates, and exhibited dose-dependent effects, with the potency being FLU.BUD.DEX (n525 per group). Conversely, CS increased cellular apoptosis (n520 per group). Furthermore, TNF-a, IL-8 and IL-6 concentrations in the supernatant were increased by STIM, and markedly reduced by all CS (n548 per group).Whole tissue cell cultures of adenoids and tonsils provide a useful approach for in vitro assessment of therapeutic efficacy of corticosteroids in the management of lymphadenoid hypertrophy that underlies obstructive sleep apnoea in children.

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“…Upper airway inflammation is consistently present among children with either habitual snoring or OSA [34,35], and inflammatory processes within the upper airway are likely to exacerbate upper airway collapsibility, as well as promote the proliferation of adenotonsillar tissues. In this context, it has become apparent that short-term exposures to traffic-related air pollutants may increase airway inflammation and/or oxidative stress in urban children [36][37][38] and, therefore, such processes would be unlikely to be restricted to the lower airways and could, in fact, be even more prominent in the upper airways considering the relative concentrations of particles more likely to deposit in the upper segments of the airways [39,40].…”

Section: Discussionmentioning

confidence: 99%

Neighbourhood air quality and snoring in school-aged children

Kheirandish‐Gozal

Ghalebandi

Salehi

et al. 2013

European Respiratory Journal

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The prevalence of habitual snoring has been extensively explored in paediatric populations. Although exposure to cigarette smoke increases the risk of habitual snoring in a dose-dependent fashion, the potential contribution of air quality to habitual snoring remains unclear. 6000 questionnaires were distributed to 6-to 12-year-old children attending public schools in five distinct neighbourhoods within the city of Tehran, Iran, that were preselected based on air quality measures. Habitual snoring was defined as loud snoring o3 nights per week. Information regarding clinical and family-related habitual snoring risk factors was also obtained. Descriptive statistics followed by adjusted risk assessments were conducted.Among the 4322 (72%) completed datasets, the prevalence of habitual snoring was 11.6%. Partition of habitual snoring rates according to neighbourhood air quality characteristics revealed significantly higher habitual snoring frequencies among children residing in neighbourhoods with greatest pollution (24.5% and 12.1% in South and Central neighbourhoods versus 7.0% and 7.7% in North and East neighbourhoods, respectively). The regional variance in habitual snoring was primarily accounted for by an integrated measure of air quality, even after controlling for other risk factors.Environmental air quality emerges as a significant and potentially modifiable contributor to the risk for developing habitual snoring during childhood. @ERSpublications Environmental pollution is an important and modifiable contributor to habitual snoring in schoolaged children

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Inflammatory Mediators in Exhaled Breath Condensate of Children With Obstructive Sleep Apnea Syndrome

Cited by 160 publications

References 42 publications

Long-Term Continuous Positive Airway Pressure Therapy Normalizes High Exhaled Nitric Oxide Levels in Obstructive Sleep Apnea

Long-Term Continuous Positive Airway Pressure Therapy Normalizes High Exhaled Nitric Oxide Levels in Obstructive Sleep Apnea

Corticosteroids suppress in vitro tonsillar proliferation in children with obstructive sleep apnoea

Neighbourhood air quality and snoring in school-aged children

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