Inflammatory mediators causing cutaneous chronic itch in some diseases via transient receptor potential channel subfamily V member 1 and subfamily A member 1

Xie, Bo; Li, Xinyu

doi:10.1111/1346-8138.14749

Cited by 31 publications

(39 citation statements)

References 61 publications

(133 reference statements)

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“…The signal is transmitted from afferent C terminal nerve fibers to neurons in the dorsal root ganglion and then spreads to the cerebral cortex resulting in pruritus. 34,35 In this study, there was a strong correlation between serum level of IL-2 and severity of RP (r = 0.750; p = 0,000). The results of the study are consistent with Fallahzadeh et al (2011), which reported a significant correlation between serum level of IL-2 and the severity of RP (p <0.0001).…”

Section: Chorazyczewska Et Al (2016) Reported Xerosissupporting

confidence: 52%

Correlation between the Serum Level of Interleukin-2 in Hemodialysis Patients and Severity of Renal Pruritus

Pranata

Kurniawati

Fitriani

et al. 2021

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A B S T R A C TRenal pruritus (RP) is a condition or symptom that is often found in end-stagechronic kidney disease (CKD) undergoing hemodialysis (HD). The etiology of RP ismultifactorial, one of it due to inflammation mediated by interleukin 2 (IL-2). Studyon the correlation between serum level of IL-2 and the severity of RP is still limited.This study will analyze the correlation between serum level of IL-2 in patientsundergoing HD and the severity of RP. Our method is cross sectional design atHemodialysis Installation of Dr. Mohammad Hoesin Hospital. Serum level of IL-2examined by ELISA, the severity of RP assessed by a 5 dimensional pruritus scale.Inclusion criteria in this study included HD patients with RP ≥ 9, age ≥ 18 years andwilling to sign informed consent. The results from 28 male (59.6%) and 19 female(40.4%) are the mean serum level of IL-2 (pg/ml) is 0.424 ± 0.077. The mean RPseverity score is 18.98 ± 2.74. A strong positive correlation between serum level ofIL-2 and the severity of RP (r = 0.750, p = 0,000). Our conclusion is the increase ofserum level IL-2 in line with severity of RP.

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Section: Chorazyczewska Et Al (2016) Reported Xerosissupporting

confidence: 52%

Correlation between the Serum Level of Interleukin-2 in Hemodialysis Patients and Severity of Renal Pruritus

Pranata

Kurniawati

Fitriani

et al. 2021

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“…Brain-type natriuretic peptide (BNP) is a surrogate marker of volume overload; in addition, BNP and its receptor have also been found in transient receptor potential (TRP) vanilloid 1 (TRPV1)–expressing neurons [ 38 , 39 ]. The TRPV1-expressing neuron transmit itch sensation from the peripheral C-fiber to the central nervous system [ 40 ]. Therefore, the increase of BNP with volume overload may have a role in itching transmission.…”

Section: Discussionmentioning

confidence: 99%

Uremic pruritus and long-term morbidities in the dialysis population

et al. 2020

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Background Uremic pruritus (UP) is a multifactorial problem that contributes to low quality of life in dialysis patients. The long-term influences of UP on dialysis patients are still poorly understood. This study aims to elucidate the contribution of UP to long-term outcomes. Materials and method We used the Taiwan National Health Insurance Research Database to conduct this study. Patients on chronic dialysis were included and divided into UP and non-UP groups according to the long-term prescription of antihistamine in the absence of other indications. The outcomes include infection-related hospitalization, catheter-related infection, major adverse cardiac and cerebrovascular events (MACCE) and parathyroidectomy. Results After propensity score matching, 14,760 patients with UP and 29,520 patients without UP were eligible for analysis. After a mean follow-up of 5 years, we found that infection-related hospitalization, MACCE, catheter-related infection, heart failure and parathyroidectomy were all slightly higher in the UP than non-UP group (hazard ratio: 1.18 [1.16–1.21], 1.05 [1.01–1.09], 1.16 [1.12–1.21], 1.08 [1.01–1.16] and 1.10 [1.01–1.20], respectively). Subgroup analysis revealed that the increased risk of adverse events by UP was generally more apparent in younger patients and patients who underwent peritoneal dialysis. Conclusion UP may be significantly associated with an increased risk of long-term morbidities.

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“…Numerous literature reports that inflammatory mediators are highly associated with immune alterations in the initiation and development of chronic inflammatory diseases [ 8 , 9 ]. Interleukin- (IL-) 17A mediates the early inflammatory stages of wound repair and may hinder normal healing [ 10 ] as evidenced by the application of IL-17 suppressive antibody that reverses delayed wound closure in leptin-deficient ob/ob mice [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

KLF4 Promotes Diabetic Chronic Wound Healing by Suppressing Th17 Cell Differentiation in an MDSC-Dependent Manner

Yang

Mathis

Huang

et al. 2021

Journal of Diabetes Research

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Objectives. Diabetic wound inflammation deficiencies lead to ulcer development and eventual amputation and disability. Our previous research demonstrates that myeloid-derived suppressor cells (MDSCs) accumulate during inflammation and promote chronic wound healing via the regulation of Kruppel-like factor 4 (KLF4). In this study, we aimed to investigate the potential roles of MDSCs and KLF4 in diabetic wound healing. Methods. An ob/ob mouse pressure ulcer (PU) model was used to evaluate the process of wound healing. The expression levels of KLF4 and IL-17A were measured by real-time PCR, and the population of MDSCs and Th17 cells was measured by flow cytometry. The levels of cytokines were determined by an immunosuppression assay. Results. KLF4 deficiency in the diabetic PU model resulted in decreased accumulation of MDSCs, increased expansion of Th17 cells, and significantly delayed wound healing. Conversely, KLF4 activation by APTO-253 accelerated wound healing accompanied by increased MDSC populations and decreased numbers of Th17 cells. MDSCs have been proven to mediate Th17 differentiation via cytokines, and our in vitro data showed that elevated KLF4 expression in MDSCs resulted in reduced Th17 cell numbers and, thus, decreased levels of cytokines indispensable for Th17 differentiation. Conclusions. Our study revealed a previously unreported function of KLF4-regulated MDSCs in diabetic wound healing and identified APTO-253 as a potential agent to improve the healing of pressure ulcers.

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Inflammatory mediators causing cutaneous chronic itch in some diseases via transient receptor potential channel subfamily V member 1 and subfamily A member 1

Cited by 31 publications

References 61 publications

Correlation between the Serum Level of Interleukin-2 in Hemodialysis Patients and Severity of Renal Pruritus

Correlation between the Serum Level of Interleukin-2 in Hemodialysis Patients and Severity of Renal Pruritus

Uremic pruritus and long-term morbidities in the dialysis population

KLF4 Promotes Diabetic Chronic Wound Healing by Suppressing Th17 Cell Differentiation in an MDSC-Dependent Manner

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