Inflammatory mediators as surrogates of malignancy

Abstract

Inflammation related to cancer occurs in the cellular vicinity of the tumour and is involved with predictions related to the course of disease and survival prognosis in varioua malignancies. These inflammatory markers affect different phases of tumourigenesis, i.e. carcinogenesis, tumour expansion, lymphovascular invasion, and distant metastasis, and, as a result, tumour cells can activate immune mediators and cells directly and/or chemokines as well as prostaglandins. Numbers of circulating different blood cells, i.e. lymphocytes, platelets, neutrophils and levels of plasma proteins, like C-reactive protein and interleukins that are components of inflammatory responses, are hallmarks of pathways leading to tumourigenesis. Thus, they can provide vital information in stratifying patients according to the risk and precisely targeted clinical care and outcome in malignancies. ---Continue

Neutrophil lymphocyte ratio and platelet lymphocyte ratio as a marker for disease severity in children with COVID-19

“…Indeed, findings indicate that these statistics could be utilized to forecast the outcome of a variety of disorders, including coronary heart disease, malignancies, and autoimmune disorders. 10 Multivariate logistic analysis was utilized to examine data from 153 cases of acute pulmonary embolism (PE) in a retrospective analysis, and it was concluded that NLR could be employed as a predictive marker determining 30-day death in pulmonary embolism. 11 Furthermore, it has been demonstrated that NLR may be employed as a measure of inflammatory responses to screen individuals contaminated with COVID-19 and can indicate poor outcome even during admission.…”