Inflammatory markers in post-traumatic stress disorder: a systematic review, meta-analysis, and meta-regression

Passos, Ives Cavalcante; Vasconcelos-Moreno, Mirela Paiva; Costa, Leonardo Gazzi; Kunz, Maurício; Brietzke, Elisa; Quevedo, Joao L De; Salum, Giovanni Abrahão; Magalhães, Pedro Vieira da Silva; Kapczinski, Flávio; Kauer-Sant’Anna, Márcia

doi:10.1016/s2215-0366(15)00309-0

Cited by 577 publications

(454 citation statements)

References 57 publications

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Section: Observational Studies In Humansmentioning

confidence: 99%

“…Metaanalyses showed that PTSD patients have moderate-tolarge elevation in several pro-inflammatory cytokines (Passos et al, 2015). Of note, these associations were not simply explained by comorbid depression (Passos et al, 2015). In addition, genetic (Michopoulos et al, 2015) and longitudinal (Eraly et al, 2014) studies suggest that inflammation is a preexisting vulnerability factor for the development of PTSD in trauma-exposed individuals rather than simply a correlate of subjective distress, disease severity, or maladaptive coping strategies following PTSD onset.…”

Section: Observational Studies In Humansmentioning

confidence: 99%

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Psychoneuroimmunology of Early-Life Stress: The Hidden Wounds of Childhood Trauma?

Danese

Lewis

2016

Neuropsychopharmacol

297

191

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The brain and the immune system are not fully formed at birth, but rather continue to mature in response to the postnatal environment. The two-way interaction between the brain and the immune system makes it possible for childhood psychosocial stressors to affect immune system development, which in turn can affect brain development and its long-term functioning. Drawing from experimental animal models and observational human studies, we propose that the psychoneuroimmunology of early-life stress can offer an innovative framework to understand and treat psychopathology linked to childhood trauma. Earlylife stress predicts later inflammation, and there are striking analogies between the neurobiological correlates of early-life stress and of inflammation. Furthermore, there are overlapping trans-diagnostic patterns of association of childhood trauma and inflammation with clinical outcomes. These findings suggest new strategies to remediate the effect of childhood trauma before the onset of clinical symptoms, such as anti-inflammatory interventions and potentiation of adaptive immunity. Similar strategies might be used to ameliorate the unfavorable treatment response described in psychiatric patients with a history of childhood trauma.

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Section: Observational Studies In Humansmentioning

confidence: 99%

Section: Observational Studies In Humansmentioning

confidence: 99%

Psychoneuroimmunology of Early-Life Stress: The Hidden Wounds of Childhood Trauma?

Danese

Lewis

2016

Neuropsychopharmacol

297

191

View full text Add to dashboard Cite

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“…We can conclude that epidural analgesia positively affects the immune system, preventing severe postoperative immuno suppression, which is particularly due to the increase in the number of CD-3-cells, B-cells, CD4/ CD8 ratio, and partially of NK-cells. In a previous study, higher cortisol levels postoperatively were shown to be associated with a higher chance of developing POCD [4,5,7,8] . Epidural anesthesia has an important influence on the modulation of the immune response in patients who underwent major orthopedic surgery.…”

Section: Discussionmentioning

confidence: 85%

“…It is essentially "deterioration in cognition temporally associated with surgery" [4,5] , and might lead to a higher mortality rate within three post-operative months [6] . A number of studies have revealed that the inflammatory response is a key factor in the development of postoperative cognitive dysfunction (POCD) [7][8][9][10] .…”

mentioning

confidence: 99%

Minimizing Stress Response and Cognitive Dysfunction in Orthopedic Surgery: The Prospects of Epidural Anesthesia

Ezhevskaya¹,

Prusakova²,

Загреков³

et al. 2017

J Anesth Surg

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“…However, both conditions appear to have similar risk for posttraumatic stress disorder (25% for miscarriage and 21% for stillbirth) 6, 7. In cross‐sectional studies, posttraumatic stress disorder has been associated with inflammatory markers and alterations in circulating lipids 29. In addition, individuals who endure highly stressful life events often alter their lifestyle choices in a way that would affect cardiovascular health 30.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Loss and Carotid Intima–Media Thickness in Mexican Women

Hartasanchez

Flores-Torres²,

Monge³

et al. 2018

JAHA

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BackgroundCardiovascular disease in women often develops without conventional risk factors. Prenatal loss is a common pregnancy outcome that may result in physiological changes can increase the potential future risk of cardiovascular disease. Insufficient information exists regarding the impact of pregnancy loss on early markers of cardiovascular disease risk.Methods and ResultsCross‐sectional analysis of 1767 disease‐free women from the MTC (Mexican Teachers' Cohort) who had been pregnant was used to evaluate the relationship between pregnancy loss and carotid intima–media thickness (IMT). Participants responded to a questionnaire regarding their reproductive history, risk factors, and medical conditions. We defined pregnancy loss as history of miscarriage and/or stillbirth. Trained neurologists measured IMT using ultrasound. We log‐transformed IMT and defined subclinical carotid atherosclerosis (SCA) as IMT ≥0.8 mm and/or plaque. We used multivariable linear and logistic regression models to assess the relation of pregnancy loss, IMT, and SCA. The mean age of participants was 49.8±5.1 years. The prevalence of pregnancy loss was 22%, and we observed SCA in 23% of participants. Comparing participants who reported a pregnancy loss and those who did not, the multivariable‐adjusted odds ratio for SCA was 1.52 (95% confidence interval, 1.12–2.06). Women who experienced a stillbirth had 2.32 higher odds (95% confidence interval, 1.03–5.21) of SCA than those who did not. Mean IMT appeared to be higher in women who reported a pregnancy loss relative to those who did not; nevertheless, this was not statistically significant.ConclusionsPregnancy loss could be linked to cardiovascular disease later in life. The key findings of our study await confirmation and further investigation of the potential underlying mechanisms for this association is required.

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Inflammatory markers in post-traumatic stress disorder: a systematic review, meta-analysis, and meta-regression

Cited by 577 publications

References 57 publications

Psychoneuroimmunology of Early-Life Stress: The Hidden Wounds of Childhood Trauma?

Psychoneuroimmunology of Early-Life Stress: The Hidden Wounds of Childhood Trauma?

Minimizing Stress Response and Cognitive Dysfunction in Orthopedic Surgery: The Prospects of Epidural Anesthesia

Pregnancy Loss and Carotid Intima–Media Thickness in Mexican Women

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