Inflammatory Markers in Induced Sputum of School Children Born Before 32 Completed Weeks of Gestation

Teig, Norbert; Allali, Manel; Rieger, Christian; Hamelmann, Eckard

doi:10.1016/j.jpeds.2012.06.007

Cited by 46 publications

(35 citation statements)

References 40 publications

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“…Such data support the hypothesis that airflow limitation in BPD survivors is unrelated to any asthma-like inflammation [16,19], indicating that another pathogenetic mechanism must be involved [19,20]. Recent reports have also suggested that prematurity may be associated with neutrophilic airway inflammation and oxidative stress later in life [21,22,23]. Available data thus support the hypothesis that the pathophysiological mechanisms behind airflow limitation in BPD and asthma probably stem from distinct mechanisms which need to be further investigated [24].…”

Section: Clinical Aspects and Functional Course Of Bpd With Agesupporting

confidence: 74%

Chronic Lung Disease of Prematurity: Long-Term Respiratory Outcome

et al. 2014

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Chronic respiratory morbidity is a common adverse outcome of preterm birth, especially in infants who develop bronchopulmonary dysplasia (BPD), which is still a major cause of long-term lung dysfunction with a heavy burden on health care services and medical resources throughout childhood. The most severely affected patients remain symptomatic even in adulthood, and this may be influenced also by environmental variables (e.g. smoking), which can contribute to persistent obstruction of airflow. Of all obstructive lung diseases in humans, BPD has the earliest onset and probably lasts the longest. Since the prevention of BPD is an elusive goal, minimizing neonatal lung injury and closely monitoring survivors remain the best courses of action. This review describes the clinical and functional changes characteristic of the long-term pulmonary sequelae of preterm birth, focusing particularly on BPD.

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Section: Clinical Aspects and Functional Course Of Bpd With Agesupporting

confidence: 74%

Chronic Lung Disease of Prematurity: Long-Term Respiratory Outcome

et al. 2014

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“…This would be in keeping with some recent studies suggesting that oxidative stress and neutrophilic inflammation persist in the lungs of prematurely born children and adolescents. 2,3 This observation is in line with the role of variable 319, which characterizes the controls with respect to the subjects with BPD. As putative biomarkers for such variable, in fact, we identified the hydroxyeicosapentaenoic acid, a compound with strong anti-inflammatory effects.…”

Section: Discussionsupporting

confidence: 76%

“…Some recent data suggest that prematurity may be associated with persistent neutrophilic airway inflammation and oxidative stress in later life. 2,3 In this study, we investigate the pathologic mechanisms behind BPD by using metabolomic approach applied to exhaled breath condensate (EBC). EBC is a biofluid collected noninvasively by cooling the air expired during tidal breathing.…”

mentioning

confidence: 99%

Airway Metabolic Anomalies in Adolescents with Bronchopulmonary Dysplasia: New Insights from the Metabolomic Approach

Carraro¹,

Giordano²,

Pirillo³

et al. 2015

The Journal of Pediatrics

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“…It may be that a better understanding of the underlying mechanisms may aid better targeted therapy especially for those with significant airway obstruction. The underlying mechanisms of airway obstruction are likely to be either inflammatory, as suggested by a single study reporting neutrophilic airway inflammation [28] and increased oxidant stress assessed by measuring 8-isoprostane concentration in exhaled breath condensate [29], or due to smooth muscle hypertrophy, as suggested by pathological studies of preterm infants dying from respiratory failure. There is a clear need to understand the underlying mechanisms before progressing to trials to assess the role of bronchodilators or anti-inflammatory treatments in this group of vulnerable children.…”

Section: Discussionmentioning

confidence: 99%

Effect of Bronchodilators on Forced Expiratory Volume in 1 s in Preterm-Born Participants Aged 5 and Over: A Systematic Review

et al. 2015

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Background and Objectives: Preterm-born participants are at risk of long-term deficits in percentage predicted forced expiratory volume in 1 s (%FEV₁). Since it is unclear if these deficits respond to bronchodilators, we systematically reviewed the evidence for reversibility of deficits in %FEV₁ by bronchodilators in preterm-born participants. Design: Studies reporting a change in %FEV₁ in response to bronchodilator treatment in preterm-born participants at ≥5 years of age, with or without a term-born control group, were identified. The quality of studies was assessed by adapted tools. Due to considerable heterogeneity between studies, formal meta-analysis was not possible. Results: From 8,839 titles, 22 studies were identified after an updated search in May 2013. Twenty-one studies assessed the response to a single inhaled dose of a bronchodilator, and 1 study assessed longer-term effects. Most studies observed decreased %FEV₁ in preterm-born participants compared with controls. Most studies observed improved %FEV₁ after a single dose of bronchodilator, with the largest improvements noted in those with bronchopulmonary dysplasia, who had greater deficits of %FEV₁ when compared with preterm and term controls. One long-term study investigated a 2-week terbutaline administration, but the initial FEV₁ after a single dose did not show a change in %FEV₁ of ≥15%, but 5/29 (17%) children had an increased %FEV₁ of ≥10%. Conclusions: In this systematic review, disparate studies were identified. Although single doses of bronchodilators appear to improve the FEV₁ in the short term, further studies are required to assess their longer-term benefits not only on airway obstruction, but also their effect on respiratory symptoms.

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Inflammatory Markers in Induced Sputum of School Children Born Before 32 Completed Weeks of Gestation

Cited by 46 publications

References 40 publications

Chronic Lung Disease of Prematurity: Long-Term Respiratory Outcome

Chronic Lung Disease of Prematurity: Long-Term Respiratory Outcome

Airway Metabolic Anomalies in Adolescents with Bronchopulmonary Dysplasia: New Insights from the Metabolomic Approach

Effect of Bronchodilators on Forced Expiratory Volume in 1 s in Preterm-Born Participants Aged 5 and Over: A Systematic Review

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