Inflammatory Markers in COVID-19

Bhandari, Sudhir; Sharma, Shrikant; Bhargava, Abhishek; Keswani, Prakash; Sharma, Rakesh; Shekhawat, Ajeet

doi:10.47102/annals-acadmedsg.2020110

Cited by 7 publications

(6 citation statements)

References 15 publications

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“…These results are in concordance with the findings of other researchers. [ 13 14 15 16 17 18 19 20 21 22 23 24 25 ] Waris et al . [ 26 ] also demonstrated similar results except that they did not find a significant association between disease severity and lymphocytopenia ( P value = 0.28).…”

Section: Discussionmentioning

confidence: 99%

Identification of hematological and inflammatory parameters associated with disease severity in hospitalized patients of COVID-19

Sana¹,

Malviya²

2022

Journal of Family Medicine and Primary Care

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Background and Objectives: India has emerged as the second worst hit nation by the Coronavirus pandemic in terms of total number of cases. Our data on hematological and inflammatory markers associated with COVID-19 is very limited. This study was conducted to assess the utility of various biomarkers in identifying severe disease. Materials and Methods: All confirmed cases of COVID-19 admitted in our tertiary care centre from 1 st March 2021 to 31 st March 2021 were enrolled in the study. They were categorized into severe and non-severe disease categories based on pre-decided criteria. Their complete blood count parameters, D-dimer levels, serum C-reactive protein (CRP), ferritin and Lactate dehydrogenase (LDH) values were retrieved. Statistical Analysis: All parameters were expressed as Mean ± Standard deviation for the two groups of patients. Student's t -test was used to test significance of the above markers between severe and non- severe disease. ( P value < 0.05 was taken as statistically significant). Results: A total of 150 COVID RT-PCR positive patients were evaluated. The patients with higher Absolute Neutrophil Count (ANC), Neutrophil to lymphocyte Ratio (NLR), Platelet to lymphocyte ratio (PLR), D-dimer levels and raised serum CRP, LDH, ferritin along with lymphocytopenia were associated with severe disease ( P < 0.05). Hemoglobin, total leucocyte count and platelet count showed no correlation with disease severity. Conclusion: These biomarkers associated with disease severity especially NLR, PLR, D-dimer and serum CRP levels could be used to triage patients at the time of admission thereby identifying those requiring intensive care and enabling optimal resource utilization.

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Section: Discussionmentioning

confidence: 99%

Identification of hematological and inflammatory parameters associated with disease severity in hospitalized patients of COVID-19

Sana¹,

Malviya²

2022

Journal of Family Medicine and Primary Care

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“…Among the 196 cases of NCP in this study, there were 107 males and 89 females (1.2:1). The ratio of male to female, BMI, and age of the severe group were greater than those of the mild group (31 vs. 13, 23.34

2.78 vs. 21.92

1.89, and 60.18

10.13 vs. 49.24

12.70, respectively), probably related to the weakened immunity of elderly obese patients [ 15 , 16 ]. In addition, 117 cases of NCP had a history of contact with confirmed patients, and 80 cases had underlying diseases.…”

Section: Discussionmentioning

confidence: 99%

Prediction and follow-up of risk factors for severe SARS-CoV-2 pneumonia and application of CT visual scoring

et al. 2021

THC

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BACKGROUND: The SARS-CoV-2 pneumonia infection is associated with high rates of hospitalization and mortality and this has placed healthcare systems under strain. Our study provides a novel method for the progress prediction, clinical treatment and prognosis of NCP, and has important clinical value for timely treatment of severe NCP patients. OBJECTIVE: To summarize the clinical features and severe illness risk factors of the patients with novel coronavirus pneumonia (NCP), in order to provide support for the progression prediction, clinical treatment and prognosis of NCP patients. MATERIALS AND METHODS: A total of 196 NCP patients treated in our hospital from January 25, 2020 to June 21, 2020 were divided into the severe group and the mild group. The clinical features of the two groups were analyzed and compared. The risk factors were explored by using multivariate logistic regression, and the receiver operating characteristic (ROC) curve was obtained. The correlations of the risk factors with the prognosis of NCP were investigated combined with the lung function test. RESULTS: The primary clinical symptoms of 196 cases of NCP included fever in 167 cases (85.2%) and cough in 121 cases (61.73%). The chest computed tomography (CT) scans of the 178 cases (90.81%) showed a typical ground-glass opacification. In 149 cases, the lymphocyte count was decreased, while the levels of creatine kinase (CK), lactate dehydrogenase (LDH), c-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and D-dimer (D-D) increased. 44 cases (22.45%) were found to be severely ill. The multivariate logistic regression analysis demonstrated that age, underlying disease, length of hospital stay, body mass index (BMI), LDH, chest CT visual score, absolute lymphocyte count (ALC) and CRP were risk factors for severe

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“…COVID-19 infection caused stimulation to the epithelial cells at the early stage, leading to intrapulmonary cell proliferation and squamous metaplasia. Patients with a course of disease shorter than ten days had hyaline membrane formation in the lungs, alveolar cell proliferation, and edema; those with a longer course of disease presented with diffuse alveolar damage 13,14 . Nicholls JM further divided the lesions into exudative, proliferative, and brotic stages 15 .…”

Section: Discussionmentioning

confidence: 99%

Natural History of Radiological Changes on CT Chest from COVID-19 Infection Rehabilitation Patients

Peng¹

2021

Preprint

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Object： To investigate the chest CT manifestations of convalescent patients with COVID-19 in recovery phase. Methods: 118 convalescent patients diagnosed as COVID-19 were followed up. According to their medical history, they were divided into 47 cases of severe disease group and 71 cases of mild disease group. Multi-slice spiral CT, high-resolution CT and pulmonary function were examined. Results: 67 rehabilitated cases are normal on CT scan. The other CT findings were: (1) ground glass opacity lesions, including: localized patchy ground glass density lesions; Multi lobes and multi-stage ground glass opacities; Diffuse ground glass opacities lesions in both lungs. (2) The interlobular interstitium and interlobular septum were thickened. (3) Subpleural arc shadow/Subpleural lines. (4) Irregular fiber cord shadow/Irregular lines. (5) Tractive bronchiectasis. (6) Nodular consolidation of air space. (7) Cavitary lesions. No obvious mediastinal lymph node enlargement and pleural effusion were found. Pulmonary imaging and pulmonary function were improved after repeated reexamination. There was significant difference in CT findings and pulmonary function indexes between severe group and mild group (P < 0.05). Conclusion: The pulmonary manifestations of some convalescent patients with COVID-19 are basically normal. Ground glass density lesions are the main CT manifestations of convalescent patients, accompanied by varying degrees of pulmonary interstitial hyperplasia. The severe group had more severe pulmonary manifestations and poor pulmonary function than the mild group. With the extension of time, pulmonary lesions and pulmonary function gradually improved.

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Inflammatory Markers in COVID-19

Cited by 7 publications

References 15 publications

Identification of hematological and inflammatory parameters associated with disease severity in hospitalized patients of COVID-19

Identification of hematological and inflammatory parameters associated with disease severity in hospitalized patients of COVID-19

Prediction and follow-up of risk factors for severe SARS-CoV-2 pneumonia and application of CT visual scoring

Natural History of Radiological Changes on CT Chest from COVID-19 Infection Rehabilitation Patients

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