Inflammatory markers in cord blood or maternal serum for early detection of neonatal sepsis—a systemic review and meta-analysis

Su, Hsuan; Chang, Shy Shin; Han, Cheng-Bo; Wu, Kun-Chan; Li, Ming-Chieh; Huang, Chung-Chi; Lee, C. L.; Wu, Jialun; Lee, C. C.

doi:10.1038/jp.2013.186

Cited by 74 publications

(71 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Rapid diagnosis and management of HCA are essential [9][10][11] . Unfortunately, clinical signs of HCA and microbiological assessment of the amniotic fluid appear to be unreliable diagnostic critera 2,3 . We investigated the role of procalcitonin (PCT) measurement in diagnosing HCA.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, PCT shows a physiological increase in the first few days of life, which complicates the interpretation of results 3 .…”

Section: Chorioamnionitis N=28 (%)mentioning

confidence: 99%

“…Howman et al observed a modest increase of inflammatory markers in the maternal and cord blood in pregnancies complicated by histological chorioamnionitis 2 . Su et al found PCT to be a relatively good rule-in and rule-out marker for prediction of neonatal sepsis 3 . One study reported elevated cord blood levels of PCT as an independant risk factor for mortality in preterm populations less than 33 weeks gestation 14 .…”

Section: Chorioamnionitis N=28 (%)mentioning

confidence: 99%

“…The most common cause of preterm birth is chorioamnionitis which is implicated in the majority of extremely preterm births. Chorioamnionitis is often asymptomatic and clinical signs lack both sensitivity and specificityover one third of women with these signs do not have histological evidence of placental inflammation as other causes may produce similar clinical features to chorioamnionitis 2,3 . Chorioamnionitis can occur without microbiologically-proven amniotic fluid infection in over half of the cases.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, PCT may be more useful than CRP in the early diagnosis of infection and monitoring of the disease 2,3 . For this reason, PCT plays an important role in the diagnosis of neonatal sepsis despite the fact that it may be elevated in non-infected infants with other complications 2 .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Procalcitonin is more likely to be released by the fetus rather than placental tissue during chorioamnionitis

Straňák¹,

Feyereisl²,

Korček³

et al. 2016

BIOMED PAP

View full text Add to dashboard Cite

Aims. To analyze the relationship between maternal, cord blood and neonatal procalcitonin (PCT) levels in preterm deliveries with and without histologically proven chorioamnionitis (HCA). Methods. 91 mother-infant pairs from 24+0 to 33+0 gestational weeks were analyzed. Procalcitonin was measured in all mothers within 24 hours before and subsequently in cord blood and in neonates within the first two hours after delivery. PCT levels were analysed in relationship to HCA and clinical outcome. Results. HCA was confirmed in 28 cases (31%). We found no differences in PCT values between HCA positive and negative groups in maternal blood (0.1±0.1 vs 0.09±0.09 ng/L, P = 0.76). PCT values in cord blood and neonates were significantly higher in the HCA positive compared to HCA negative group (0.23±0.1 vs 1.2±2.7 ng/L, P < 0.001 and 0.89±3.4 vs 4.2±9.3 ng/L, P < 0.0001 respectively). PCT values in neonates were significantly higher than those of cord blood. Levels were not influenced by the mode of delivery, gestational age or premature rupture of membranes. Chorioamnionitis was more frequently associated with early onset neonatal sepsis (36% in HCA group vs 5% in non HCA group, P < 0.0001). Comparison of other clinical data revealed no differences between HCA positive and negative groups. Conclusion. This study showed higher PCT in cord and neonatal blood in the presence of proven histological chorioamnionitis. The measurement of PCT in mothers' blood is not helpful for diagnosis of HCA. The changes in PCT values shown suggest its production and release by fetal tissue.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Furthermore, PCT shows a physiological increase in the first few days of life, which complicates the interpretation of results 3 .…”

Section: Chorioamnionitis N=28 (%)mentioning

confidence: 99%

Section: Chorioamnionitis N=28 (%)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Procalcitonin is more likely to be released by the fetus rather than placental tissue during chorioamnionitis

Straňák¹,

Feyereisl²,

Korček³

et al. 2016

BIOMED PAP

View full text Add to dashboard Cite

show abstract

Progress of Research in Neonatal Sepsis

Chen

Shi

2019

Severe Trauma and Sepsis

View full text Add to dashboard Cite

Neonatal sepsis remains a significant global problem with little progress made despite major efforts. At present, there is a lack of an accepted international consensus on the definition, diagnosis, and treatment of neonatal sepsis; the unclear understanding of the pathogenesis of neonatal sepsis leads to blindness in treatment, which will result in an unsatisfactory therapeutic outcome. In addition, some serious diseases caused by noninfectious factors, such as trauma, stress, asphyxia, and so on, have very similar pathophysiological results with neonatal sepsis. In this review we synthesize the recent advances in definition, incidence, causative agents, risk factors, pathophysiology, clinical manifestations, and diagnosis and treatment of neonatal sepsis. Of course, there are still many challenges to neonatal sepsis in many ways.

show abstract

Soluble TREM-1 as a predictive factor of neonatal sepsis: a meta-analysis

et al. 2018

View full text Add to dashboard Cite

Current evidence suggests that sTREM-1 may become a useful biomarker for the prediction of neonatal sepsis. However, the small number of studies and the variation of the threshold values limit its implementation in clinical practice. Future large-scale studies are needed to determine the optimal cut-off value that may discriminate normal levels from those suggestive of the presence of neonatal sepsis.

show abstract

Inflammatory markers in cord blood or maternal serum for early detection of neonatal sepsis—a systemic review and meta-analysis

Cited by 74 publications

References 34 publications

Procalcitonin is more likely to be released by the fetus rather than placental tissue during chorioamnionitis

Procalcitonin is more likely to be released by the fetus rather than placental tissue during chorioamnionitis

Progress of Research in Neonatal Sepsis

Soluble TREM-1 as a predictive factor of neonatal sepsis: a meta-analysis

Contact Info

Product

Resources

About