Inflammatory markers are elevated in overweight Mexican-American children

McFarlin, Brian K.; Johnston, Craig A.; Tyler, Chermaine; Hutchison, Alexander; Kueht, Michael; Reeves, Rebecca S.; Foreyt, John P.

doi:10.1080/17477160701440455

Cited by 25 publications

(32 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TNF-a was also unrelated to the abdominal obesity of our participants and had an independent predictive value only for the decreased concentrations of HDL-C. Similar data in children were demonstrated by Steene-Johannessen et al (10) and others (26,31), while Caballero et al (11) and Aygun et al (19) reported raised TNF-a in obese children.…”

Section: Discussionsupporting

confidence: 73%

Circulating proinflammatory peptides related to abdominal adiposity and cardiometabolic risk factors in healthy prepubertal children

Galcheva¹,

Iotova²,

Yotov

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

Objectives: To analyze the circulating levels of proinflammatory peptides in healthy prepubertal children in relation to abdominal obesity, measured by waist circumference (WC), and to investigate their interactions with cardiometabolic risk factors. Design and methods: A cross-sectional study of 137 healthy prepubertal children with a mean age of 8.0G0.1 years divided into three groups according to their WC as a measure of abdominal obesity: 'normal-WC' children (25th-75th percentile, nZ48), 'children at risk' (75th-90th percentile, nZ39), and 'abdominally obese' (R90th percentile, nZ50) children. Auxological measurements and blood pressure (BP) were taken. Fasting levels of high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL6), tumor necrosis factor-a (TNF-a), glucose, insulin, and lipid profile were measured. Insulin resistance (IR) was assessed by homeostasis model assessment of IR (HOMA-IR). Results: Abdominally obese children had significantly higher BP, insulin, HOMA-IR, total cholesterol and triglycerides (TG) compared with their normal-WC counterparts (P!0.05). HsCRP concentrations increased proportionally with the degree of abdominal obesity (rZ0.443, P!0.0001), whereas IL6 and TNF-a were not significantly associated with any of the adiposity variables. After controlling for adiposity, hsCRP was significantly correlated with systolic BP (rZ0.257, PZ0.004), TNF-a levels were related to high-density lipoprotein cholesterol (HDL-C; rZK0.216, PZ0.016) and TG (rZ0.196, PZ0.029), whereas the relationship between IL6 and HDL-C reduced its magnitude to an insignificant level (rZK0.173, PZ0.055). Conclusions: Healthy prepubertal children with abdominal obesity have associated inflammatory and cardiometabolic alterations, interacting with each other.

show abstract

Section: Discussionsupporting

confidence: 73%

Circulating proinflammatory peptides related to abdominal adiposity and cardiometabolic risk factors in healthy prepubertal children

Galcheva¹,

Iotova²,

Yotov

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…20,37 While we are not the first group to highlight the increased disease risk associated with childhood obesity, 18,20,37,38 we are the first, to our knowledge, to demonstrate a concurrent increase in systemic inflammation and monocyte concentration in obese Mexican American children. Future research should seek to further explore the long-term relationship between the circulating markers used in the study and incidence of CVD and DM2.…”

Section: Figurementioning

confidence: 84%

“…This sample size was selected based on a previously published study from a different cohort examining other inflammatory disease biomarkers. 18 Parental consent forms were given to all students enrolled in sixth or seventh grade, and students were asked to return the forms with a parent' s signature indicating whether they wished to participate in the study. Child assent was obtained after parent consent.…”

Section: Subjectsmentioning

confidence: 99%

“…[15][16][17][18] None of these studies, however, have explored the relationship between monocytes, systemic inflammation, and disease risk markers in overweight and obese children. Currently, approximately one-third of American children are overweight or obese (standardized BMI [zBMI] .85th percentile for age/gender), with slightly higher prevalence in Mexican American children compared with non-Hispanic white children.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Obese Mexican American Children Have Elevated MCP-1, TNF-α, Monocyte Concentration, and Dyslipidemia

Breslin

Johnston²,

Strohacker

et al. 2012

Pediatrics

Self Cite

View full text Add to dashboard Cite

show abstract

“…10,11,14 For example, increases in fat mass are associated with decreased production of adiponectin as well as increased production of leptin and proinflammatory cytokines (TNF-a, IL-1b, and IL-6). 15 By controlling for changes in fat mass, we are able to demonstrate that the feeding pattern described in this report mirrors body fat distributions in obese humans. Collectively, these results indicate that by increasing the amount of macronutrient fat content, it is possible to increase weight gain and reduce the number of animals needed for a desired outcome.…”

mentioning

confidence: 78%

Considerations to maximize fat mass gain in a mouse model of diet-induced weight gain

2013

View full text Add to dashboard Cite

Mouse experimental models of diet-induced weight gain are commonly used as analogs to human obesity; however, a wide variety of feeding methods have been used and the most effective way to maximize weight gain is not known. Maximizing weight gain may allow for a reduction in the number of animals required for a given experiment. The purpose of this study was how to cause the greatest amount of weight gain in CD-1 mice by modifying the composition and source of their diet. To accomplish this goal, we completed two experiments: (1) Effect of dietary macronutrient fat intake (60% (HF60), 45% (HF45), 30% (HF30), or 13.5% (CON) fat diet for 18 weeks); and (2) Effect of 1:1 mixed HF60 and CON diets. Outcome measures included food intake, body mass, and body composition, which were measured bi-weekly and statistically analyzed using a repeated measures analysis of variance (RM-ANOVA). In Experiment 1, the greatest increase in body and fat mass was observed in HF60 (36%) and HF45 (29%) compared with HF30 and CON (P < 0.05). In Experiment 2, HF þ stock diet (SK) gained 25% more body mass and 70% more fat mass than HF (P < 0.05). Collectively, these findings suggest that using a high-fat based diet (>45% calories from fat), mixed with a stock diet, results in substantially more weight gain over a similar period, of time, which would allow an investigator to use $40% fewer animals in their experimental model. Keywords mouse diet-induced weight gain, dietary fat, obesity, disease, mixed dietsIn the past decade, the prevalence of overweight/obesity has reached epidemic levels in many parts of the world, resulting in a rise in morbidity and premature mortality.1,2 Studying the longitudinal effects of dietinduced weight gain in humans is problematic due to ethical considerations. Thus, rodent weight gain models are an attractive analog for human obesity. One limitation of the current studies is that a wide variety of weight gain methodology has been used and it is not clear which method most effectively maximizes weight gain. [3][4][5][6][7][8][9] Through a series of investigations, our laboratory has sought to address this limitation in the current literature. We have previously demonstrated that mice that are group-housed (groups of five) and restricted from structured physical activity have greater weight gain than normal growth rates.10,11 Consistent with reports from other laboratories, we have also demonstrated that extremely high-fat diets (60% of calories from fat) result in excessive weight gain above normal growth.10 Neither our laboratory nor others have specifically compartmentalized weight gain into lean and

show abstract

Inflammatory markers are elevated in overweight Mexican-American children

Abstract: Overweight Mexican-American children had a higher concentration of inflammatory biomarkers than healthy weight children. To our knowledge, this is the first study to report that sCD14 is elevated in overweight compared with healthy weight Mexican-American children.

Cited by 25 publications

References 52 publications

Circulating proinflammatory peptides related to abdominal adiposity and cardiometabolic risk factors in healthy prepubertal children

Circulating proinflammatory peptides related to abdominal adiposity and cardiometabolic risk factors in healthy prepubertal children

Obese Mexican American Children Have Elevated MCP-1, TNF-α, Monocyte Concentration, and Dyslipidemia

Considerations to maximize fat mass gain in a mouse model of diet-induced weight gain

Contact Info

Product

Resources

About