Inflammatory markers and risk of cardiovascular mortality in relation to diabetes status in the HUNT study

Løfblad, Lena; Hov, Gunhild Garmo; Åsberg, Arne; Videm, Vibeke

doi:10.1038/s41598-021-94995-8

Cited by 16 publications

(9 citation statements)

References 42 publications

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“…In two previous large population-based cohort studies, higher levels of hs-CRP were also related to higher risk of cardiovascular mortality, in line with our current findings [ 28 , 29 ]. Both of the studies found no difference in results for patients with or without diabetes.…”

Section: Discussionsupporting

confidence: 93%

Low-grade inflammation as a risk factor for cardiovascular events and all-cause mortality in patients with type 2 diabetes

Sharif

Graaf

Cramer

et al. 2021

Cardiovasc Diabetol

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Background Type 2 diabetes is a condition associated with a state of low-grade inflammation caused by adipose tissue dysfunction and insulin resistance. High sensitive-CRP (hs-CRP) is a marker for systemic low-grade inflammation and higher plasma levels have been associated with cardiovascular events in various populations. The aim of the current study is to evaluate the relation between hs-CRP and incident cardiovascular events and all-cause mortality in high-risk type 2 diabetes patients. Methods Prospective cohort study of 1679 type 2 diabetes patients included in the Second Manifestations of ARTerial disease (SMART). Cox proportional hazard models were used to evaluate the risk of hs-CRP on cardiovascular events (composite of myocardial infarction, stroke and vascular mortality) and all-cause mortality. Hs-CRP was log-transformed for continuous analyses. Findings were adjusted for age, sex, BMI, current smoking and alcohol use, non-HDL-cholesterol and micro-albuminuria. Results 307 new cardiovascular events and 343 deaths occurred during a median follow-up of 7.8 years (IQR 4.2–11.1). A one unit increase in log(hs-CRP) was related to an increased vascular- and all-cause mortality risk (HR 1.21, 95% CI 1.01–1.46 and HR 1.26, 95% CI 1.10–1.45 respectively). No relation was found between log(hs-CRP) and myocardial infarction or stroke. The relations were similar in patients with and without previous vascular disease. Conclusion Low grade inflammation, as measured by hs-CRP, is an independent risk factor for vascular- and all-cause mortality but not for cardiovascular events in high-risk type 2 diabetes patients. Chronic low-grade inflammation may be a treatment target to lower residual cardiovascular risk in type 2 diabetes patients.

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Section: Discussionsupporting

confidence: 93%

Low-grade inflammation as a risk factor for cardiovascular events and all-cause mortality in patients with type 2 diabetes

Sharif

Graaf

Cramer

et al. 2021

Cardiovasc Diabetol

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“…First, compared to fat stored in other parts of the body, abdominal fat greatly afects infammation [27]. Further, recently, infammatory markers such as C-reactive protein have been reported to be associated with cardiovascular mortality [28]. Second, abdominal visceral adiposity is associated with impaired inhibition of adipocyte lipolysis and elevated levels of non-esterifed fatty acids, leading to vascular endothelial dysfunction [29].…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in the Relationship between Abdominal Obesity and Cardiovascular Death in Elderly Patients with Permanent Pacemakers Implantation: A Retrospective Cohort Study

Xue

Zhao

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Objectives. This study aims to investigate the association between waist circumference (WC) and cardiovascular death in patients with permanent pacemakers (PPMs). Methods. This is a retrospective cohort study that enrolled patients who underwent PPM implantation in Fuwai Hospital from May 2010 to April 2014, according to the BIOTRONIK Home Monitoring database. The WC was treated as sex-specific quartiles, and patients were divided into three groups according to body mass index (BMI): normal (≤22.9 kg/m2), overweight (23–24.9 kg/m2), and obese (≥25 kg/m2). Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals for cardiovascular death according to WC and BMI in patients. Results. 492 patients with PPMs implantation were analyzed (mean age: 71.9 ± 10.8 years; 55.1% men (n = 271)). Data showed that after a mean follow-up 67.2 ± 17.5 months, 24 (4.9%) patients had experienced cardiovascular death and 71 (14.4%) were cases of all-cause mortality. Men in the third quartile of WC had an HR of 10.67 (Model 4, 95% CI: 1.00–115.21, p trend = 0.04) for cardiovascular death. However, the association disappeared in female patients (Model 4, HR = 3.99, 95% CI: 0.37–42.87, p trend = 0.25). There was no association between BMI and cardiovascular death or all-cause mortality in both male and female patients. Conclusions. Abdominal obesity was associated with an increased risk of cardiovascular death in patients with PPMs, and this relationship was only in male patients.

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“…Some researchers found that CRP was a signi cant predictor of cardiovascular disease only among individuals without diabetes (18, 39, 40). The others, in contrast, have demonstrated that the association between CRP and cardiovascular mortality did not differ by diabetes status (19,20,41). The same is true for brinogen research.…”

Section: Discussionmentioning

confidence: 94%

Association between Superoxide Dismutase, C-Reactive Protein, Fibrinogen and Heart Failure in Patients with Diabetes and Acute Coronary Syndrome

Jiang

Chen

et al. 2022

Preprint

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Background: Superoxide dismutase (SOD) and inflammatory markers are reported to have association with cardiovascular disease. However, no previous study has assessed the value of SOD and inflammatory markers as predictive indicator of heart failure in patients with diabetes and acute coronary syndrome (ACS) in the same study. Objective: The objective of this study is to compare the predictive implications of SOD activity, C-reactive protein (CRP) and fibrinogen for reduced left ventricular ejection fraction (LVEF) in patients with diabetes and ACS. Method: The study included 2377 inpatients with type 2 diabetes who had an ACS admitted to the Shandong Provincial Hospital affiliated to Shandong First Medical University from January 2016 to January 2021. Result: Despite taking the lowest quartile as reference (OR 0.368, 95% CI 0.493–0.825, P = 0.001) or examining 1 normalized unit increase (OR 0.651, 95% CI 0.482–0.880, P = 0.005), the SOD activity was exhibited to be the strongest predictive indicator of reduced LVEF, independent of confounding factors. The SOD activity showed the most powerful predictor value for reduced LVEF with the highest area under the receiver operating characteristic curve of 0.658. Conclusions: SOD activity is a stronger predictor of reduced LVEF than CRP and fibrinogen in patients with diabetes and ACS.

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Inflammatory markers and risk of cardiovascular mortality in relation to diabetes status in the HUNT study

Cited by 16 publications

References 42 publications

Low-grade inflammation as a risk factor for cardiovascular events and all-cause mortality in patients with type 2 diabetes

Low-grade inflammation as a risk factor for cardiovascular events and all-cause mortality in patients with type 2 diabetes

Sex Differences in the Relationship between Abdominal Obesity and Cardiovascular Death in Elderly Patients with Permanent Pacemakers Implantation: A Retrospective Cohort Study

Association between Superoxide Dismutase, C-Reactive Protein, Fibrinogen and Heart Failure in Patients with Diabetes and Acute Coronary Syndrome

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