Inflammatory indices predict pharyngocutaneous fistula formation after total laryngectomy

Yücel, Levent; Yıldırım, Sibel Aksu; Guliyev, Hasay; Başak, Hazan; Büyükatalay, Zahide Çiler; Beton, Süha

doi:10.5152/b-ent.2021.21539

Cited by 1 publication

(4 citation statements)

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“…diagnostic OR was calculated as (TP/FP)/(FN/TN) with 95% confidence intervals (CI) using random-effects models that accounted for both withinstudy and between-study variation. 1,4,5,10, diagnostic OR ranges from zero to infinity with a higher ratio indicating better diagnostic performance. A value of 1 is null, meaning that the test cannot determine whether a disease has occurred.…”

Section: Data Extraction and Risk Of Bias Assessmentmentioning

confidence: 99%

“…The results measured were diagnostic odds ratio (OR) for diagnostic accuracy, sROC curve, and AUC. diagnostic OR was calculated as (TP/FP)/(FN/TN) with 95% confidence intervals (CI) using random‐effects models that accounted for both within‐study and between‐study variation 1,4,5,10,15–68 . diagnostic OR ranges from zero to infinity with a higher ratio indicating better diagnostic performance.…”

Section: Participants Interventions Comparisons Outcomes Timings and ...mentioning

confidence: 99%

“…2 However, the significance of these parameters varies from study to study. 5 In addition, the diagnostic value of risk factors has not been fully assessed. Also, previous studies did not provide diagnostic measures, such as sensitivity, specificity, summary receiver operating characteristic (sROC) curves, and area under the curve (AUC) values.…”

Section: Introductionmentioning

confidence: 99%

“…Several potential risk factors, such as age, smoking status, coronary artery disease, chronic obstructive pulmonary disease, preoperative low albumin level, preoperative low hemoglobin level, T stage, tumor site, type of pharyngeal closure method used, preoperative tracheostomy, previous radiation therapy, and salvage surgery, have been proposed as causes of PCF 2 . However, the significance of these parameters varies from study to study 5 . In addition, the diagnostic value of risk factors has not been fully assessed.…”

Section: Introductionmentioning

confidence: 99%

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Predictive Value of Risk Factors for Pharyngocutaneous Fistula After Total Laryngectomy

Kim

Hwang

2022

The Laryngoscope

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Objectives: To assess the predictive value of various risk factors for pharyngocutaneous fistula (PCF) after total laryngectomy.Methods: The characteristics of each study were collected from six databases up to January of 2022. Risk for bias was assessed using the QUADAS-2 tool.Results: A total of 58 studies in 9845 patients were included in the analysis. The incidence of PCF was 21.69%, 95% confidence intervals (CI) [0.20; 0.24] in the included studies. Age (OR = 1.33, 95% CI [1.12; 1.58]), postoperative anemia (OR = 2.29, 95% CI [1.47; 3.57]), diabetes mellitus (OR = 1.81, 95% CI [1.20; 2.71]), tumor site (above or below the glottis) (OR = 1.47, 95% CI [1.15; 1.88]), previous radiation therapy (OR = 2.06, 95% CI [1.56; 2.72]), previous tracheostomy (OR = 1.26, 95% CI [1.04; 1.53]), surgery timing (salvage vs. primary) (OR = 2.08, 95% CI [1.46; 2.97]), extended total laryngectomy (including pharyngectomy) (OR = 1.96, 95% CI [1.28; 3.00]), primary tracheoesophageal puncture (OR = 0.61, 95% CI [0.40; 0.93]), and postoperative hypoproteinemia (OR = 9.98, 95% CI [3.68; 27.03]) were significantly associated with the occurrence of PCF. In view of predictive ability, postoperative hypoproteinemia showed the highest accuracy (sensitivity = 51%, specificity = 90%, area under the curve = 0.84).Conclusion: Multiple patient-, disease-, and surgery-related factors are risk factors for PCF. In particular, postoperative hypoproteinemia could be a good predictive factor for PCF in patients undergoing total laryngectomy.

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Section: Data Extraction and Risk Of Bias Assessmentmentioning

confidence: 99%

Section: Participants Interventions Comparisons Outcomes Timings and ...mentioning

confidence: 99%