Inflammatory Fibroid Polyp of the Gastrointestinal Tract: A Systematic Review for a Benign Tumor

Garmpis, Nikolaos; Damaskos, Christos; Garmpi, Anna; Georgakopoulou, Vasiliki; Sakellariou, Stratigoula; Liakea, Aliki; Schizas, Dimitrios; Diamantis, Evangelos; Farmaki, Paraskevi; Voutyritsa, Errika; Syllaios, Athanasios; Patsouras, Alexandros; Sypsa, Georgia; Agorogianni, Alexandra; Stelianidi, Athanasia; Antoniou, Efstathios; Kontzoglou, Konstantinos; Τράκας, Νικόλαος; Dimitroulis, Dimitrios

doi:10.21873/invivo.12235

Cited by 16 publications

(21 citation statements)

References 121 publications

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“…Clinical presentation can be acute, subacute or chronic and depends on tumour location and size. Gastric lesions usually present with epigastric pain and bleeding, whereas pain obstruction due to intussussepcion -as occurred in our report-are the most the frequent presentation in the small bowel (17.0% -77%, 27%-12.5%, respectively) [6,16]. Other gastrointestinal symptoms include vomiting, diarrhoea, tenesmus, alterations in bowel habits, and weight loss.…”

Section: Case Presentationsupporting

confidence: 55%

“…Small bowel lead points are mostly benign in nature (lipomas, hamartomous polyps, inflammatory polyps, hyperplastic polyps and Meckel's diverticulum, Peutz-Jager Syndrome, Henoch Schoenlein Purpura and tuberculosis), although there have been reports of metastatic lesions. Contrarily, large bowel lesions are frequently associated to a malignant etiology [2, 4,6,7]. This discrepancy accounts for the different management approaches proposed and described ahead.…”

Section: Discussionmentioning

confidence: 99%

“…In our report, an IFP was the cause of an ileoileal intussusception. Recent studies have shown that these lesions are rare and mostly present in around the fifth to seventh decades [3,6]. Even though a slight female predominance has been reported, the female-to-male ratio may vary from ranging from 2.8: 1 to 0.7: 1.…”

Section: Discussionmentioning

confidence: 99%

“…We hereby present a case of an adult ileoileal intussusception, diagnosticated preoperatively, managed by open surgery and subsequently attributed to an Inflammatory Fibroid Polyp. Even though it is not difficult to find reports of such lesions in literature [3,5,9], our particular histological findings of a CD34+ CD117+ lesion, raises awareness to the existence of different hystological variants and antigen expressions of the IFPs and emphasizes the complexity of their diagnosis [4][5][6].…”

Section: Introductionmentioning

confidence: 91%

“…We decided to implement an en bloc resection in our patient having in mind the -even if small-, non-negligible incidence of malignancy in small bowel intussusception (1 -47% ileoileal vs 43 -100% in ileocolic and colocolic intussusceptions) and the inherent inability to accurately differentiate benign form malignant etiologies intraoperatively. Furthermore, IFP resection is usually curative since there have been no reports of recurrence in literature [6].…”

Section: Case Presentationmentioning

confidence: 99%

See 4 more Smart Citations

Inflammatory Fibroid Polyp causing small bowel intussusception: a case report

Santo¹,

Cottier²,

Sguinzi³

et al. 2021

Med Case Rep Rev

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Inflammatory fibroid polyps (IFP), or Vanek's tumours, are rare lesions of the gastrointestinal tract whose clinical presentation and management vary according to lesion's size and location. We hereby present a case of an ileoileal intussusception accurately diagnosed by computer tomography. Laparotomy and small bowel resection were performed. A PDGFRA+ IFP was identified as the lead point and its rare CD117(c-kit) positivity emphasizes the histological variety of these lesions as well as the complexity thus inherent to a conclusive diagnosis.

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Section: Case Presentationsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Section: Case Presentationmentioning

confidence: 99%

See 3 more Smart Citations

Inflammatory Fibroid Polyp causing small bowel intussusception: a case report

Santo¹,

Cottier²,

Sguinzi³

et al. 2021

Med Case Rep Rev

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Benign Diseases of the Stomach

Majumdar

Ganguly

Das

2022

Surgical Pathology of the Gastrointestinal System

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Inflammatory fibroid polyp of the renal pelvis: first report at an extra-gastrointestinal site with molecular confirmation

et al. 2023

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Inflammatory fibroid polyps (IFP) are rare and benign mesenchymal tumours of the gastrointestinal tract. They are submucosal spindle cell lesions with an eosinophilic-rich inflammatory infiltrate and mutations in the platelet-derived growth factor receptor alpha (PDGFRA) gene. In this report, we present the case of a 74-year-old female with a solid tumour of the kidney, which presented as a bland proliferation of spindle cells with thin-walled blood vessels and an inflammatory infiltrate with eosinophilic granulocytes. Immunohistochemistry revealed a positivity for vimentin and a weak staining for CD99 and CD34 in the spindle cells. Because of the morphological similarity to IFPs of the gastrointestinal tract, a molecular pathology analysis was performed. This identified an oncogenic mutation in exon 18 of the PDGFRA gene, which is characteristic for inflammatory fibroid polyps of the gastrointestinal tract. To the best of our knowledge, this is the first case of an IFP in the urogenital tract.

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Inflammatory Fibroid Polyp of the Gastrointestinal Tract: A Systematic Review for a Benign Tumor

Cited by 16 publications

References 121 publications

Inflammatory Fibroid Polyp causing small bowel intussusception: a case report

Inflammatory Fibroid Polyp causing small bowel intussusception: a case report

Benign Diseases of the Stomach

Inflammatory fibroid polyp of the renal pelvis: first report at an extra-gastrointestinal site with molecular confirmation

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