Inflammatory effects of hexavalent chromium in the lung: A comprehensive review

Kouokam, J. Calvin; Meaza, Idoia; Wise, John Pierce

doi:10.1016/j.taap.2022.116265

Cited by 17 publications

(10 citation statements)

References 74 publications

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“…Likewise, IARC have clearly noted that inhaled CR(VI) is a carcinogen element resulting in an increased lung cancer via inhalation exposure [ 97 , 100 ]. Environmental Protection Agency (EPA) classified Cr (III) compounds as a non-carcinogenic element (group D), and no information are available on the reproductive or developmental effects of Cr (III) in human [ 101 ].…”

Section: Resultsmentioning

confidence: 99%

Concentration of heavy metals in pasteurized and sterilized milk and health risk assessment across the globe: A systematic review

Alinezhad,

Hashemi,

Tavakoly Sany

2024

PLoS ONE

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Objective Although milk and dairy products are almost complete food, they can contain toxic heavy elements with potential hazards for consumers. This review aims to provide a comprehensive report on the occurrence, concentration, and health risks of selected heavy metals in pasteurized and sterilized milk recorded worldwide. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) was used to develop this systematic review. Databases included the Web of Knowledge, Scopus, Scientific Information Database, Google Scholar, and PubMed from inception until January 2023. Keywords related to the terms “Heavy metals”, “Arsenic” and “Pasteurized and sterilized milk” and “Risk Assessment” were used. The potential health risks to human health from milk daily consumption were estimated using extracted data on heavy metals concentration based on metal estimated daily intake, target hazard quotient, and carcinogenic risk. Results A total of 48 potentially relevant articles with data on 981 milk samples were included in the systematic review. Atomic Absorption Spectroscopy, atomic absorption spectroscopy, inductively coupled plasma-mass spectrometry, and inductively coupled plasma-optical emission spectrometry were the most common valid methods to measure heavy metals in milk samples. Following the initial evaluation, Cu, Cd, Zn, and Pb were the most contaminants, which exceeded the maximum permissible criteria in 94%, 67%, 62%, and 46% of the milk samples tested. Relying on target hazard quotient and carcinogenic risk results, milk consumers in 33(68.75%) and 7 (14.5%) studies were exposed to moderate to high levels of carcinogenic and non-carcinogenic risk, respectively. The highest level of risk is due to the consumption of pasteurized and sterilized milk detected in Pakistan, Brazil, Egypt, Slovakia, and Turkey. Conclusion The elevated levels of heavy metals in milk samples, especially Pb and Cd is a public health concern; therefore, maximum control and strict regulations must be adopted to decrease heavy metals contaminants in the dairy industry. Further studies are required to develop safe milk processing and handling methods for the decontamination of heavy metals in milk and its products.

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Section: Resultsmentioning

confidence: 99%

Concentration of heavy metals in pasteurized and sterilized milk and health risk assessment across the globe: A systematic review

Alinezhad,

Hashemi,

Tavakoly Sany

2024

PLoS ONE

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“…Several cytokines are responsible to control the activation or inhibition of the immune responses during the initiation of oxidative stress induced by inhalation of heavy metals. [28] Of these, IFN-γ produced by the pathogenic T-cells play a pivotal role in the pathogenesis of heavy metal induced oxidative stress. [29] The ROS generated by the heavy metals selectively activates Fyn-dependent JAK-STAT signalling for the induction of IFN responsive genes leading to an elevation in the levels IFN-γ.…”

Section: Treatment With Aerosolized Cà Mn 3 O 4 Nps Reduces Markers O...mentioning

confidence: 99%

“…[34] Oxidative damage to the lung mitochondria may lead to the initiation of the inflammation pathway NF-kβ, JAK-STAT, leading into a cytokine storm. [28] Therefore, we evaluated the mitochondrial parameters in different experimental cohorts. The results clearly suggest that Cr induced toxicity in lungs triggered detrimental alterations in the mitochondria resulting in degenerative redox signalling.…”

Section: Aerosolized Cà Mn 3 O 4 Nps Mitigates Redox-mediated Inflamm...mentioning

confidence: 99%

“…[28] The accumulation of Cr 6 + ions also triggers an enhanced ROS generation in the cellular milieu (Figure 8) acting as mediators to alter the mitochondrial functioning. [28] In accordance, in this study, we observed a dysregulation in the mitochondrial parameters (decreased Complex IV activity, elevated level of mitochondrial ROS, opening of mPTP, etc) due to excessive ROS generation as the effect of disease pathogenesis leading to the activation of the signalling cascade in the lung resulting in an induction of inflammatory interleukins (ILs). The observed overexpression of neutrophils in lung and increased IL-1β and IFN-γ levels further support this argument.…”

Section: F Aerosolized Cà Mn 3 O 4 Nps Inhibits the Vicious Cycle Of ...mentioning

confidence: 99%

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Targeted Redox Balancing through Pulmonary Nanomedicine Delivery Reverses Oxidative Stress Induced Lung Inflammation

Ghosh,

Das,

Mondal

et al. 2024

ChemMedChem

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Non‐invasive delivery of drugs is important for the reversal of respiratory diseases essentially by‐passing metabolic pathways and targeting large surface area of drug absorption. Here, we study the inhalation of a redox nano medicine namely citrate functionalized Mn3O4 (C‐Mn3O4) duly encapsulated in droplet evaporated aerosols for the balancing of oxidative stress generated by the exposure of Chromium (VI) ion, a potential lung carcinogenic agent. Our optical spectroscopic in‐vitro experiments demonstrates the efficacy of redox balancing of the encapsulated nanoparticles (NP) for the maintenance of a homeostatic condition. The formation of Cr‐NP complex as an excretion of the heavy metal is also demonstrated through optical spectroscopic and high resolution transmission optical microscopy (HRTEM). Our studies confirm the oxidative stress mitigation activity of the Cr‐NP complex. A detailed immunological assay followed by histopathological studies and assessment of mitochondrial parameters in pre‐clinical mice model with chromium (Cr) induced lung inflammation establishes the mechanism of drug action to be redox‐buffering. Thus, localised delivery of C‐Mn3O4 NPs in the respiratory tract via aerosols can act as an effective nanotherapeutic agent against oxidative stress induced lung inflammation.

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“…LC is more frequent in high-income countries, mainly due to smoking habits that represent the main risk factor for this malignancy ( McIntyre and Ganti, 2017 ; Sung et al, 2021 ). Other common risk factors are the exposure to some chemicals such as asbestos ( Markowitz, 2022 ), mustard gas ( Ghanei and Harandi, 2010 ), radon ( Lorenzo-González et al, 2019 ), arsenic ( Soza-Ried et al, 2019 ), chromium ( Kouokam et al, 2022 ), nickel ( Shen and Zhang, 1994 ), uranium ( Zhang et al, 2022 ), vinyl chloride ( Girardi et al, 2022 ) and high dose ionizing radiations ( Yan et al, 2022 ).…”

Section: Lung Cancer Epidemiologymentioning

confidence: 99%

Ion channels in lung cancer: biological and clinical relevance

Capitani,

Chioccioli Altadonna,

Santillo

et al. 2023

Front. Pharmacol.

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Despite improvements in treatment, lung cancer is still a major health problem worldwide. Among lung cancer subtypes, the most frequent is represented by adenocarcinoma (belonging to the Non-Small Cell Lung Cancer class) although the most challenging and harder to treat is represented by Small Cell Lung Cancer, that occurs at lower frequency but has the worst prognosis. For these reasons, the standard of care for these patients is represented by a combination of surgery, radiation therapy and chemotherapy. In this view, searching for novel biomarkers that might help both in diagnosis and therapy is mandatory. In the last 30 years it was demonstrated that different families of ion channels are overexpressed in both lung cancer cell lines and primary tumours. The altered ion channel profile may be advantageous for diagnostic and therapeutic purposes since most of them are localised on the plasma membrane thus their detection is quite easy, as well as their block with specific drugs and antibodies. This review focuses on ion channels (Potassium, Sodium, Calcium, Chloride, Anion and Nicotinic Acetylcholine receptors) in lung cancer (both Non-Small Cell Lung Cancer and Small Cell Lung Cancer) and recapitulate the up-to-date knowledge about their role and clinical relevance for a potential use in the clinical setting, for lung cancer diagnosis and therapy.

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Inflammatory effects of hexavalent chromium in the lung: A comprehensive review

Cited by 17 publications

References 74 publications

Concentration of heavy metals in pasteurized and sterilized milk and health risk assessment across the globe: A systematic review

Concentration of heavy metals in pasteurized and sterilized milk and health risk assessment across the globe: A systematic review

Targeted Redox Balancing through Pulmonary Nanomedicine Delivery Reverses Oxidative Stress Induced Lung Inflammation

Ion channels in lung cancer: biological and clinical relevance

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