Inflammatory effect on the gastrointestinal system associated with COVID-19

Delgado-González, Paulina; Gonzalez-Villarreal, Carlos A.; Roacho-Pérez, Jorge A.; Quiroz-Reyes, Adriana G.; Islas, José Francisco; Delgado-Gallegos, Juan Luis; Arellanos-Soto, Daniel; Galán-Huerta, Kame; Garza-Treviño, Elsa N.

doi:10.3748/wjg.v27.i26.4160

Cited by 12 publications

(4 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…COVID-19 could influence the body through pre-existing GI conditions, and IBD, such as ulcerative colitis and Crohn's disease, is a great concern. It is established that these conditions influence the prognosis of COVID-19 patients [50]. A population-based investigation by Maconi et al compared the risk of COVID-19 in IBD patients and control subjects [51].…”

Section: Patients With Pre-existing Gi Diseasesmentioning

confidence: 99%

Digestive System Involvement During Coronavirus Disease 2019; the Newest Clinical Features and Potential Mechanisms

Kashkooli

Jooya

Navari

et al. 2022

GMJ

View full text Add to dashboard Cite

The coronavirus disease 2019 (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has been recognized as a worldwide pandemic and mostly affects the respiratory system. A considerable proportion of patients; however, might also experience gastrointestinal (GI) manifestations. Several investigations have assessed GI and hepatic involvement in this disease, although the mechanisms of these involvements in relation to the progression of COVID-19 remain unclear. This review summarized the clinical observations and the main mechanisms behind GI, liver, and pancreatic involvement among COVID-19 patients.

show abstract

Section: Patients With Pre-existing Gi Diseasesmentioning

confidence: 99%

Digestive System Involvement During Coronavirus Disease 2019; the Newest Clinical Features and Potential Mechanisms

Kashkooli

Jooya

Navari

et al. 2022

GMJ

View full text Add to dashboard Cite

show abstract

“…Severe acute respirator y syndrome-coronavir us 2 (SARS-coV-2) is the pathogen responsible for causing SARS-coV-2 pneumonia [coronavirus disease 2019 (cOVId- 19)]. The initial clinical symptoms of viral infection are frequently atypical and include mild coughing and headaches (1,2). The increase in SARS-coV-2 infection cases has also led to the emergence of a number of characteristic stomach symptoms.…”

Section: Introductionmentioning

confidence: 99%

Digestive system infection by SARS‑CoV‑2: Entry mechanism, clinical symptoms and expression of major receptors (Review)

et al. 2023

View full text Add to dashboard Cite

Besides causing severe acute respiratory syndrome (SARS), SARS-coronavirus 2 (SARS-coV-2) also harms the digestive system. Given the appearance of numerous cases of SARS-coV-2, it has been demonstrated that SARS-coV-2 is able to harm target organs such as the gastrointestinal tract, liver and pancreas, and either worsen the condition of patients with basic digestive illnesses or make their prognosis poor. According to several previously published studies, angiotensin-converting enzyme II (AcE2) and transmembrane serine protease II (TMPRSS2) are expressed either singly or in combination in the digestive system and in other regions of the human body. In order to change the viral conformation, create a fusion hole and release viral RNA into the host cell for replication and transcription, SARS-coV-2 is capable of binding to these two proteins through the spike protein on its surface. As a result, the body experiences an immune reaction and an inflammatory reaction, which may lead to nausea, diarrhea, abdominal pain and even gastrointestinal bleeding, elevated levels of liver enzymes, acute liver injury, pancreatitis and other serious lesions. In order to provide possible strategies for the clinical diagnosis and treatment of digestive system diseases during the cOVId-19 pandemic, the molecular structure of SARS-coV-2 and the mechanism via which SARS-coV-2 enters the human body through AcE2 and TMPRSS2 were discussed in the present review, and the clinical manifestations of SARS-coV-2 infection in the digestive system were also summarized. Finally, the expression characteristics of AcE2 and TMPRSS2 in the main target organs of the digestive system were described. Contents1. Introduction 2. Structural features and molecular mechanism of SARS-coV-2 entry into cells 3. clinical manifestations of SARS-coV-2 infection and gastrointestinal expression of AcE2 and TMPRSS2 4. SARS-coV-2 and the liver 5. SARS-coV-2-infected pancreatic symptoms and expression of associated proteins 6. conclusions

show abstract

“…The ubiquitous distribution of the ACE2 receptors in several tissues may explain the multi-organ dysfunction linked to COVID-19, as well as the inflammatory and immune components [ 4 ]. Hence, the presence of the SARS-CoV-2 genome has already been reported outside the respiratory tract, most notably in the kidney, gastrointestinal system, nervous system and blood vessels, with some arguments in favor of a local replication [ 5 , 6 , 7 , 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Viruses 2022, 14, 515 2 of 10 components [4]. Hence, the presence of the SARS-CoV-2 genome has already been reported outside the respiratory tract, most notably in the kidney, gastrointestinal system, nervous system and blood vessels, with some arguments in favor of a local replication [5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Multiorgan and Vascular Tropism of SARS-CoV-2

Hartard

Chaqroun

Settembre

et al. 2022

Viruses

View full text Add to dashboard Cite

Although the respiratory tract is the main target of SARS-CoV-2, other tissues and organs are permissive to the infection. In this report, we investigated this wide-spectrum tropism by studying the SARS-CoV-2 genetic intra-host variability in multiple tissues. The virological and histological investigation of multiple specimens from a post-mortem COVID-19 patient was performed. SARS-CoV-2 genome was detected in several tissues, including the lower respiratory system, cardio-vascular biopsies, stomach, pancreas, adrenal gland, mediastinal ganglion and testicles. Subgenomic RNA transcripts were also detected, in favor of an active viral replication, especially in testicles. Ultra-deep sequencing allowed us to highlight several SARS-CoV-2 mutations according to tissue distribution. More specifically, mutations of the spike protein, i.e., V341A (18.3%), E654 (44%) and H655R (30.8%), were detected in the inferior vena cava. SARS-CoV-2 variability can contribute to heterogeneous distributions of viral quasispecies, which may affect the COVID-19 pathogeny.

show abstract

Inflammatory effect on the gastrointestinal system associated with COVID-19

Cited by 12 publications

References 74 publications

Digestive System Involvement During Coronavirus Disease 2019; the Newest Clinical Features and Potential Mechanisms

Digestive System Involvement During Coronavirus Disease 2019; the Newest Clinical Features and Potential Mechanisms

Digestive system infection by SARS‑CoV‑2: Entry mechanism, clinical symptoms and expression of major receptors (Review)

Multiorgan and Vascular Tropism of SARS-CoV-2

Contact Info

Product

Resources

About