Inflammatory Disorders of the Skin

Murphy, Michael J.; Phelps, Amanda; Braun‐Falco, Markus

doi:10.1007/978-1-60761-171-4_14

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Inflammatory Dermatoses1

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2012

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“…For routine clinical applications, the goal may be to interface molecular diagnostic strategies with more widely available methodologies (i.e. immunohistochemistry), which would facilitate rapid and inexpensive investigation of encoded protein expression in skin samples and correlation of genomic/proteomic changes with the microscopic features of a particular disease 56 . For example, as predicted by gene expression profiling, high levels of human beta defensin‐2 protein expression have been confirmed by immunohistochemistry in lesional skin of psoriasis, with minimal or absent staining for this protein in lesional skin of eczematous dermatoses (AD, ACD, and ICD) 44,57 …”

Section: Inflammatory Dermatosesmentioning

confidence: 99%

Molecular diagnostic strategies: a role in the practice of dermatology

2012

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Molecular diagnostic strategies are gaining wider acceptance and use in dermatology and dermatopathology as more practitioners in this field develop an understanding of the principles and applications of genomic technologies. Molecular testing is facilitating more accurate diagnosis, staging, and prognostication, in addition to guiding the selection of appropriate treatment, monitoring of therapy, and identification of novel therapeutic targets, for a wide variety of skin diseases.

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Section: Inflammatory Dermatosesmentioning

confidence: 99%