Scleritis and peripheral ulcerative keratitis (PUK) can present as isolated conditions or as part of a systemic inflammatory or infectious disorder. Both are serious ocular conditions that can result in vision loss and therefore require early diagnosis and treatment. Nearly two-thirds of patients with non-infectious scleritis require systemic glucocorticoid therapy, and one fourth need a glucocorticoid-sparing agent, as well. Essentially all patients with non-infectious PUK require systemic glucocorticoids. Detailed clinical history, thorough physical examination, and thoughtful laboratory evaluations are all important in the exclusion of underlying disorders and extraocular involvement.
KeywordsScleritis; peripheral ulcerative keratitis; glucocorticoids; cyclophosphamide; vasculitis; rheumatoid arthritis Scleritis and peripheral ulcerative keratitis (PUK) are two ocular disorders that require urgent attention for the purpose of diagnosis, treatment, and detection of underlying systemic inflammatory diseases.