Inflammatory Diseases of the Peripheral Cornea

Mondino, Bartly J.

doi:10.1016/s0161-6420(88)33164-7

Cited by 151 publications

(72 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In his study improvement was in 3 cases and 6 cases remained same. 9 This is in agreement with our study that soft contact lenses are useful in majority of corneal perforation and descemetocoel as they cause rapid reformation of anterior chamber and healing if uses temporarily. In present study improvement in case of corneal ulcer was reported in 70 % cases.…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

A clinical study to evaluate therapeutic efficacy of soft contact lenses in corneal diseases

Punjabi

Bedi

2016

Int J Res Med Sci

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 93%

“…10 Mondino BJ also reported improvement in patients of corneal ulcer. 9 The results of our study are comparable with the studies done by other workers that contact lenses promote healing by rapid epithelisation of ulcer.…”

Section: Discussionsupporting

confidence: 91%

A clinical study to evaluate therapeutic efficacy of soft contact lenses in corneal diseases

Punjabi

Bedi

2016

Int J Res Med Sci

View full text Add to dashboard Cite

“…Abnormal T cell responses have been found in several studies on PUK [39][40][41]. It is hypothesized that T cells lead to antibody production and the formation of immune complexes that deposit in the peripheral cornea [42]. The complement pathway is activated with recruitment of inflammatory cells to the cornea.…”

Section: Pathogenesis Of Pukmentioning

confidence: 99%

Scleritis and Peripheral Ulcerative Keratitis

Galor

Thorne

2007

Rheumatic Disease Clinics of North America

141

138

View full text Add to dashboard Cite

Scleritis and peripheral ulcerative keratitis (PUK) can present as isolated conditions or as part of a systemic inflammatory or infectious disorder. Both are serious ocular conditions that can result in vision loss and therefore require early diagnosis and treatment. Nearly two-thirds of patients with non-infectious scleritis require systemic glucocorticoid therapy, and one fourth need a glucocorticoid-sparing agent, as well. Essentially all patients with non-infectious PUK require systemic glucocorticoids. Detailed clinical history, thorough physical examination, and thoughtful laboratory evaluations are all important in the exclusion of underlying disorders and extraocular involvement. KeywordsScleritis; peripheral ulcerative keratitis; glucocorticoids; cyclophosphamide; vasculitis; rheumatoid arthritis Scleritis and peripheral ulcerative keratitis (PUK) are two ocular disorders that require urgent attention for the purpose of diagnosis, treatment, and detection of underlying systemic inflammatory diseases.

show abstract

“…Although corneal clarity can be diminished by inflammatory reactions, inflammation characterized by an infiltration of neutrophils can be generated within diseased or damaged corneal tissues (1)(2)(3). The mechanisms by which neutrophils are recruited to the eye surface from blood vessels surrounding the clear cornea surface are not clear.…”

mentioning

confidence: 99%

Calcitonin Gene-Related Peptide Induces IL-8 Synthesis in Human Corneal Epithelial Cells

Tran

Ritchie

Lausch

et al. 2000

The Journal of Immunology

View full text Add to dashboard Cite

Calcitonin gene-related peptide (CGRP), a neuropeptide with proinflammatory activities, is released from termini of corneal sensory neurons in response to pain stimuli. Because neutrophil infiltration of the clear corneal surface is a hallmark of corneal inflammation in the human eye, we determined whether CGRP can bind to human corneal epithelial cells (HCEC) and induce expression of the neutrophil chemotactic protein IL-8. It was found that HCEC specifically bound CGRP in a saturable manner with a Kd of 2.0 × 10−9 M. Exposure of HCEC to CGRP induced a significant increase in intracellular cAMP levels and enhanced IL-8 synthesis nearly 4-fold. The capacity of CGRP to stimulate cAMP and IL-8 synthesis was abrogated in the presence of the CGRP receptor antagonist CGRP8–37. CGRP stimulation had no effect on the half-life of IL-8 mRNA while increasing IL-8 pre-mRNA synthesis >2-fold. In contrast to IL-8, CGRP did not induce monocyte chemotactic protein-1 or RANTES synthesis, nor did the neuropeptide enhance detectable increases in steady state levels of mRNA specific for these two β-chemokines. The results suggest that HCEC possess CGRP receptors capable of initiating a signal transduction cascade that differentially activates expression of the IL-8 gene but not the genes for monocyte chemotactic protein-1 or RANTES. The capacity of CGRP to stimulate IL-8 synthesis in HCEC suggests that sensory neurons are involved in induction of acute inflammation at the eye surface.

show abstract

Inflammatory Diseases of the Peripheral Cornea

Cited by 151 publications

References 38 publications

A clinical study to evaluate therapeutic efficacy of soft contact lenses in corneal diseases

A clinical study to evaluate therapeutic efficacy of soft contact lenses in corneal diseases

Scleritis and Peripheral Ulcerative Keratitis

Calcitonin Gene-Related Peptide Induces IL-8 Synthesis in Human Corneal Epithelial Cells

Contact Info

Product

Resources

About