Inflammatory demyelinating diseases of the central nervous system in Niger

Assadeck, Hamid; Daouda, Moussa Toudou; Omar, Eric Adehossi; Mamadou, Zakaria; Djibo, Fatimata Hassane; Maiga, Djibo Douma

doi:10.1016/j.neurol.2018.05.003

Cited by 10 publications

(13 citation statements)

References 26 publications

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“…The NMO-to-MS ratio is lower in North African countries (9:67, 36 64:503, 42 20:330, 37 8:877 38 ) and higher in studied populations from sub-Saharan Africa (2:0 29 , 4:3 41 , 95:2 43 ).…”

Section: Demographic Characteristicsmentioning

confidence: 75%

“…The data collection period varied between 1 year and 21 years (Table 1). Many studies documented a diagnosis of NMOSD using the IPND 2015 6 [39][40][41] However, definitions used to diagnose NMO/NMOSD varied between studies and differed according to the year of publication (Table 3). The time to diagnosis from onset of the symptoms ranged from weeks to years, with most studies stating a time to diagnosis of more than 9 months.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…No definite conclusions on the association of these concurrent infections, that are highly prevalent on the African continent, were drawn. 37,41,42,44,47,48,[50][51][52] Visual evoked potentials (VEP) were abnormal in the majority of the patients in whom they were performed. 36,38,39,44,48,51,52 Optical coherence tomography was mentioned only in 1 study and was abnormal in a patient with recurrent ON.…”

Section: Clinical Presentation and Comorbiditiesmentioning

confidence: 99%

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Neuromyelitis Optica Spectrum Disorders in Africa

Musubire

Derdelinckx

Reynders

et al. 2021

Neurol Neuroimmunol Neuroinflamm

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Background and ObjectivesNeuromyelitis optica (NMO) is a CNS inflammatory disease that predominantly affects the optic nerves and the spinal cord. It is more frequent in Asian and African populations than in European ones. Data on epidemiology, clinical presentation, additional investigations, and treatment in the African continent are scarce. We aim to (1) collect and analyze published data on neuromyelitis optica spectrum disorder (NMOSD), (2) indicate challenges in the diagnosis and management, and (3) discuss opportunities for future research, education, and policy making, specifically on the African continent.MethodsA systematic review was performed in January 2021 with the search terms “Neuromyelitis optica and Africa,” “Devic Disease and Africa,” and “NMOSD and Africa.” We included all study types except case reports, correspondence, or conference abstracts on NMO or NMOSD. Extracted data included study design, country, study period, demographic and clinical characteristics, results of paraclinical investigations, and outcome. Data analysis was performed with descriptive statistics.ResultsWe retrieved a total of 79 records, of which 19 were included. Ten of 54 African countries reported a total of 410 cases. Almost half of them were from North African countries. The mean age at diagnosis was 33 years (range 7–88 years), and 75% were female. Transverse myelitis followed by optic neuritis were the most frequent symptoms at the time of presentation. One hundred nineteen patients experienced at least 1 previous relapse, and 106 had a relapsing course after diagnosis. Relapses were treated with IV methylprednisolone. Azathioprine and steroids were used most often as maintenance treatments. Outcomes were rarely described.DiscussionThe majority of studies on NMOSD from the African continent are retrospective, and most countries do not report any data. Our systemic review shows that data derived from patients living in Africa correspond well to what has been previously published in meta-analyses on patients of African ancestry with NMOSD who live outside of Africa, except for a younger age at onset and a lower proportion of females. We advocate for systematic data collection to adequately capture and monitor the burden of NMOSD, for expansion of research efforts and facilities to perform fundamental and clinical research, and for improved access to health care including diagnostics, treatments, and rehabilitation services for people affected by NMOSD in the African continent.

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“…The NMO-to-MS ratio is lower in North African countries (9:67, 36 64:503, 42 20:330, 37 8:877 38 ) and higher in studied populations from sub-Saharan Africa (2:0 29 , 4:3 41 , 95:2 43 ).…”

Section: Demographic Characteristicsmentioning

confidence: 75%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Clinical Presentation and Comorbiditiesmentioning

confidence: 99%

See 1 more Smart Citation

Neuromyelitis Optica Spectrum Disorders in Africa

Musubire

Derdelinckx

Reynders

et al. 2021

Neurol Neuroimmunol Neuroinflamm

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“…The pathogenesis theories of Alzheimer’s disease include the cholinergic injury theory, AB theory, tau protein theory, neuroinflammation theory, oxidative stress theory, etc. In recent years, neuroinflammation has received increasing attention [ 3 ]. A neuroinflammatory model of lipopolysaccharide-induced microglia has become increasingly common in studies of Alzheimer’s disease using BV2 cells, which are mouse glial cells [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Isolation of Phenolic Compounds from Raspberry Based on Molecular Imprinting Techniques and Investigation of Their Anti-Alzheimer’s Disease Properties

Naeem

Zou

et al. 2022

Molecules

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Alzheimer’s disease is the most common neurodegenerative disease, characterized by memory loss and cognitive dysfunction. Raspberry fruits contain polyphenols which have antioxidant and anti-inflammatory properties. In this study, we used molecular imprinting technology to efficiently isolate phenolic components from the raspberry ethyl acetate extracts. Six phenolic components (ellagic acid, tiliroside, kaempferol-3-o-rutoside, gallic acid, ferulic acid and vanillic acid) were identified by UPLC-Q-TOF-MS analysis. Molecular docking was used to predict the anti-inflammatory effects and anti-Alzheimer’s potential of these isolated compounds, which showed a good binding ability to diseases and related proteins. However, the binding energy and docking fraction of ellagic acid, tiliroside, and kaempferol-3-o-rutoside were better than those of gallic acid, ferulic acid and vanillic acid. Additionally, by studying the effects of these six phenolic components on the LPS-induced secretion of inflammatory mediators in murine microglial (BV2) cells, it was further demonstrated that they were all capable of inhibiting the secretion of NO, IL-6, TNF-α, and IL-1β to a certain extent. However, ellagic acid, tiliroside, and kaempferol-3-o-rutoside have better inhibitory effects compared to others. The results obtained suggest that the phenolic components extracted from ethyl acetate extracts of raspberry by molecularly imprinted polymers have the potential to inhibit the progression of Alzheimer’s disease.

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“…Since Osuntokun in Nigeria in 1970, 8 cases of NMO/NMOSD have been reported in black African countries. 9 10 11 12 13 14 In Togo, nearly 55% of the population lives in multidimensional poverty, the guaranteed interprofessional minimum wage (GIMW) is 35,000 CFA francs ($US64), while the rate of health insurance coverage is estimated at nearly 5%. We conducted a hospital-based study with the objective of describing possible peculiarities of NMOSD in our setting.…”

Section: Introductionmentioning

confidence: 99%

Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020)

Apétsè

Kouassi

Anayo

et al. 2022

JNRP

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Introduction Neuromyelitis optica spectrum disorders (NMOSD) would disproportionately affect blacks within mixed populations. However, they are rarely reported in black African. The objective of this work was to report the experience of Togo, a West African country in terms of NMOSD. Methods This is a series of six cases diagnosed between 2015 and 2020 in the only three neurology departments in Togo. The diagnosis of NMOSD was made according to the criteria of the International Panel for NMO Diagnosis (2015) and the patients had a minimum clinical follow-up of 6 months after the diagnosis. The search for anti-aquaporin 4 (AQP4) antibodies was performed by immunofluorescence on transfected cells. Results The mean age was 25.33 years and the sex ratio female/male was 5/1. The average time between the first attack and the diagnosis was 122.83 days. Clinically, there was isolated medullary involvement (2/6), simultaneous opticomedullary involvement (3/6), and area postrema syndrome (1/6). Five patients were anti-AQP4 positive. All six patients had extensive longitudinal myelitis. At 6 months of follow-up, there was one case of death and one case of blindness. Conclusion The rarity of NMOSD cases in Togo could be linked to an underestimation. To better characterize the NMOSDs of the black African population, multicenter and multidisciplinary studies are necessary.

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Inflammatory demyelinating diseases of the central nervous system in Niger

Cited by 10 publications

References 26 publications

Neuromyelitis Optica Spectrum Disorders in Africa

Neuromyelitis Optica Spectrum Disorders in Africa

Isolation of Phenolic Compounds from Raspberry Based on Molecular Imprinting Techniques and Investigation of Their Anti-Alzheimer’s Disease Properties

Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020)

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