Inflammatory cytologic alterations in the oral epithelium associated with HIV pre-exposure prophylaxis: a preliminary study

Baggio, Gabriela Leite; Macedo, Nayara Flores; Merlin, Júlio Cezar; Anghebem, Mauren Isfer; Santos, Juliane Cardoso Villela; Ignácio, Sérgio Aparecido; Rubira-Bullen, Izabel Regina Fischer; Azevedo‐Alanis, Luciana Reis; Souza, Paulo Henrique Couto

doi:10.1016/j.oooo.2021.01.010

Cited by 2 publications

(3 citation statements)

References 38 publications

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“…Almost all of the participants reported access to dental care (97.8%). The sample was entirely composed of patients belonging to a key population at risk of exposure to HIV ( 1 ). These key populations are subject to disproportionate risks and vulnerabilities, do not have equiTable access to health care, experience health outcomes below those recommended, and deserve a priority response based on basic human rights ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

“…The patient’s demographic data and medical history were obtained from the database of the Orientation and Counseling Center in Curitiba ( 1 ).…”

Section: Methodsmentioning

confidence: 99%

“…By the end of 2018, 37.9 million people worldwide had HIV infection. Besides, in that year, approximately 1.7 million new infections occurred, with 54% of these new infections affecting key populations and their sexual partners, such as people who use alcohol and other drugs, serodiscordant couples, transvestites and trans people, gays, men who have sex with men, sex workers, and people deprived of their liberty ( 1 ). Given that no single prevention method or approach can stop the HIV epidemic, some new methods and interventions have been adopted to reduce the risk of HIV infection, including the use of antiretroviral drugs, such as preexposure prophylaxis (PrEP) ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

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Oral conditions and salivary analysis in HIV-uninfected subjects using preexposure prophylaxis

Macedo¹,

Baggio²,

Henn³

et al. 2022

Med Oral

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Background New prevention strategies have been advocated to control the progression of HIV/AIDS, such as preexposure prophylaxis (PrEP). The aim of this study is to evaluate the potential changes in the oral and salivary conditions of HIV-uninfected subjects using PrEP. Material and Methods Subjects were evaluated before beginning the medication (T0), at the first follow-up (T1), and at the second follow-up (T2). Xerostomia, presence of untreated cavitated caries, oral hygiene habits, taste, gingival and plaque index, stimulated salivary flow rate (SSFR), and salivary concentrations of calcium, glucose, urea, and total proteins were evaluated. Data obtained were analyzed using statistical tests ( p <0.05). Results Forty-seven participants (41 men; 6 women) were evaluated at T0. Thirty (28 men; 2 women) and 17 men were reassessed at T1 and T2, respectively. There was no difference between the SSFR and oral and salivary conditions between T0, T1, and T2 ( p >0.05), except for the salivary calcium concentration, that increased at T2 compared to T1 ( p =0.02). There was significant difference between taste and xerostomia at T1 ( p =0.017), and the need to drink to swallow at T2 ( p =0.015). There was significant correlation between the reported amount of saliva and taste ( p =0.039, r=-0.378) at T1. Conclusions The prolonged use of PrEP seems to be associated with reports of dry mouth and worsening of taste, possibly associated with increased salivary calcium concentration. Key words: Antiretroviral agents, pre-exposure prophylaxis, saliva, oral health.

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Section: Discussionmentioning

confidence: 99%

“…The patient’s demographic data and medical history were obtained from the database of the Orientation and Counseling Center in Curitiba ( 1 ).…”

Section: Methodsmentioning

confidence: 99%