Inflammatory cytokines in robot-assisted thoracic surgery versus video-assisted thoracic surgery

Jaradeh, Mark; Curran, Brett; Poulikidis, Kostantinos; Rodrigues, Adrian E.; Jeske, Walter; Abdelsattar, Zaid M.; Lubawski, James; Walenga, Jeanine M.; Vigneswaran, Wickii T.

doi:10.21037/jtd-21-1820

Cited by 5 publications

(3 citation statements)

References 45 publications

(60 reference statements)

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“…Grzelak et al [37] showed that even a minor procedure like a cholecystectomy can produce a rise in systemic cytokines, including interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-10 and IFN-γ. In addition, one study [38] compared two procedures performed for anatomic lung resection in patients with malignant cancer, taking into consideration 11 types of cytokines. The researchers concluded that the plasma levels of interleukin (IL)-6 and the monocyte chemo-attractant protein-1 (MCP-1) were higher for the video-assisted thoracic surgery (VATS) group than for the roboticassisted thoracic surgery (RATS) group.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Inflammatory Systemic Biomarkers and Surgical Trauma in Elderly Patients with Hip Fractures

Moldovan

Ivănescu

Fodor

et al. 2023

JCM

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The treatment for hip fractures consists of a wide variety of orthopedic implants ranging from prosthesis to intramedullary nails. The purpose of this study is to determine the correlation between blood-count-derived biomarkers such as the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), the monocyte-to-lymphocyte ratio (MLR) and the systemic immune-inflammation index (SII) and the level of aggression sustained by elderly patients during these surgical procedures. A total of 129 patients aged over 70 and diagnosed with acute hip fractures who underwent surgical treatment between November 2021 and February 2023 were included in our observational retrospective cohort study. Two groups were formed depending on the anatomic location of the fracture for statistical comparison: group 1 with extracapsular fractures, who received a closed reduction internal fixation (CRIF) with a gamma nail (GN) as treatment, and group 2 with intracapsular fractures, who received a bipolar hemiarthroplasty (BHA) as treatment. The length of hospital stay (LHS), duration of surgery, preoperative days, pre- and postoperative red blood count (RBC) and hemoglobin (HGB) levels and postoperative NLR, PLR and SII were significantly different between the two groups (p < 0.05). Furthermore, the multivariate analysis indicated that the postoperative NLR (p = 0.029), PLR (p = 0.009), SII (p = 0.001) and duration of surgery (p < 0.0001) were independently related to the invasiveness of the procedures. The ROC curve analysis demonstrated that a postoperative SII > 1564.74 is a more reliable predictor of surgical trauma in terms of specificity (58.1%) and sensitivity (56.7%). Postoperative SII as a biomarker appears to be closely correlated with surgical trauma sustained by an older population with hip fractures.

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Section: Discussionmentioning

confidence: 99%

Correlation between Inflammatory Systemic Biomarkers and Surgical Trauma in Elderly Patients with Hip Fractures

Moldovan

Ivănescu

Fodor

et al. 2023

JCM

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“…Inflammatory cytokines such as interleukin (IL)-1, IL-6, and tumour necrosis factor-alpha (TNFalpha) are known to surge in the bloodstream after a traumatic operation. Studies have shown decreased immune-chemokine disturbance with VATS procedures, but no studies have studied systemic inflammatory response [33] .…”

Section: Trans-sternal Thymectomy Vs Video Assisted Thoracoscopic Sur...mentioning

confidence: 99%

An Overview of Thymectomy Approaches among Myasthenia Graves Patients: Review Article

Desoky¹,

Emam²,

Ragab³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Myasthenia gravis (MG) is a syndrome characterized by fatigue-and activity-induced improvements in skeletal muscular weakening. There is a wide range of possible involvement, including but not limited to the muscles of the eyes, face, oropharynx, trunk, and limbs. Once the patient's level of weakness has been managed to the point that surgery is possible, thymectomy is recommended. Preoperatively, patients are typically treated with mild doses of intravenous immunoglobulins as well as glucocorticoids. Objective: Review of the literature on thymectomy approaches among myasthenia graves' patients. Methods: We scoured medical journals and databases including PubMed, Google Scholar, and Science Direct for information on thymectomy and myasthenia graves. Between September 2006 and August 2022, however, only the latest or most comprehensive study was considered. The authors also assessed the usefulness of references drawn from similar books. Documents written in languages other than English have been overlooked because of lack of funding to translate them. Unpublished articles, oral talks, conference abstracts, and dissertations were all generally agreed upon not to constitute valid scientific investigation. Conclusion: It has been argued that a maximum thymectomy, in which both the transsternal and transcervical techniques are used on the same MG patient, yields superior results. After extensive transsternal thymectomy or video-assisted thoracoscopic thymectomy, half of patients with non-thymomatous MG had complete stable remissions at 6 years of follow-up.

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“…These factors promote the proliferation and migration of endothelial cells, the building blocks of blood vessels, leading to the expansion of the tumor's vascular network [7]. In addition, it has been reported that these factors are induced after surgery, but those levels are lower in robotic surgery, a minimally invasive surgical technique, compared to conventional surgery [8,9].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis for Anti-Cancer Target-Indication Prioritization of Placental Growth Factor Inhibitor (PGF) by Use of Omics and Patient Survival Data

Kim

Shin

et al. 2023

Biology

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The expression of the placental growth factor (PGF) in cancer cells and the tumor microenvironment can contribute to the induction of angiogenesis, supporting cancer cell metabolism by ensuring an adequate blood supply. Angiogenesis is a key component of cancer metabolism as it facilitates the delivery of nutrients and oxygen to rapidly growing tumor cells. PGF is recognized as a novel target for anti-cancer treatment due to its ability to overcome resistance to existing angiogenesis inhibitors and its impact on the tumor microenvironment. We aimed to integrate bioinformatics evidence using various data sources and analytic tools for target-indication identification of the PGF target and prioritize the indication across various cancer types as an initial step of drug development. The data analysis included PGF gene function, molecular pathway, protein interaction, gene expression and mutation across cancer type, survival prognosis and tumor immune infiltration association with PGF. The overall evaluation was conducted given the totality of evidence, to target the PGF gene to treat the cancer where the PGF level was highly expressed in a certain tumor type with poor survival prognosis as well as possibly associated with poor tumor infiltration level. PGF showed a significant impact on overall survival in several cancers through univariate or multivariate survival analysis. The cancers considered as target diseases for PGF inhibitors, due to their potential effects on PGF, are adrenocortical carcinoma, kidney cancers, liver hepatocellular carcinoma, stomach adenocarcinoma, and uveal melanoma.

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Inflammatory cytokines in robot-assisted thoracic surgery versus video-assisted thoracic surgery

Cited by 5 publications

References 45 publications

Correlation between Inflammatory Systemic Biomarkers and Surgical Trauma in Elderly Patients with Hip Fractures

Correlation between Inflammatory Systemic Biomarkers and Surgical Trauma in Elderly Patients with Hip Fractures

An Overview of Thymectomy Approaches among Myasthenia Graves Patients: Review Article

Comprehensive Analysis for Anti-Cancer Target-Indication Prioritization of Placental Growth Factor Inhibitor (PGF) by Use of Omics and Patient Survival Data

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