Inflammatory cytokines and NT-proCNP in Parkinson’s disease patients

Koziorowski, Dariusz; Tomasiuk, Ryszard; Szlufik, Stanisław; Friedman, Andrzej

doi:10.1016/j.cyto.2012.07.030

Cited by 116 publications

(83 citation statements)

References 33 publications

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“…Data are presented as a mean ± SD. demonstrated in the PD patients, possibly due to a high SD (Koziorowski et al, 2012). However, Blum-Degen et al demonstrated increased levels of IL-1β in the CSF of PD patients (Blum-Degen et al, 1995).…”

Section: Discussionmentioning

confidence: 88%

The interleukin 1 alpha, interleukin 1 beta, interleukin 6 and alpha-2-macroglobulin serum levels in patients with early or late onset Alzheimer's disease, mild cognitive impairment or Parkinson's disease

Dursun

Gezen-Ak

Hanağası

et al. 2015

Journal of Neuroimmunology

206

118

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Section: Discussionmentioning

confidence: 88%

The interleukin 1 alpha, interleukin 1 beta, interleukin 6 and alpha-2-macroglobulin serum levels in patients with early or late onset Alzheimer's disease, mild cognitive impairment or Parkinson's disease

Dursun

Gezen-Ak

Hanağası

et al. 2015

Journal of Neuroimmunology

206

118

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“…MPTP-mediated toxicity is induced by 1-methyl-4-phenyl-2,3-dihydropyridiumion (MPP + ), which was converted by monoamine oxidase B in astrocytes [20]. Recently, many studies showed that damaged substantianigra striatum regions had T, B lymphocyte cell infiltration in PD, and damaged regions had high levels of inflammatory factor, tumour necrosis factor α (TNF-α), interleukin 1β (IL-1β), IL-1, IL-2, IL-4, IL-6 and some chemokines [21,22,23,24]. Further studies found the peripheral T-cells pool had been changed, specifically that CD4 + T cells had been decreased in PD [12,14,25].…”

Section: Discussionmentioning

confidence: 99%

Damage of Neuroblastoma Cell SH-SY5Y Mediated by MPP+ Inhibits Proliferation of T-Cell Leukemia Jurkat by Co-Culture System

Wang

Awan

Wang

et al. 2014

IJMS

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The adaptive immune system has implications in pathology of Parkinson’s disease (PD). Research data demonstrated that the peripheral CD4+ T-cell population decreased in pathogenesis of PD. The effect of damaged dopaminergic neurons on peripheral T cells of PD is still unknown. In this study, we constructed a neuronal and glial cells co-culture model by using human neuroblastoma cells SH-SY5Y and gliomas cells U87. After the co-culture cells were treated with neurotoxin 1-methyl-4-phenylpyridinium (MPP+) for 24 h, the conditioned media was harvested and used to cultivate T-cell leukemia Jurkat cells for another 24 h. We then analyzed the cell proliferation, cell cycle and necrosis effect of Jurkat cells. The results showed that co-culture medium of SH-SY5Y and U87 cells with MPP+ treatment inhibited the proliferation of Jurkat cells compared to control medium without MPP+, even though the same concentration of MPP+ had very little toxicity to the Jurkat cell. Furthermore, co-culture medium with low concentration of MPP+ (100 µM) arrested Jurkat cells cycle in G2/M phase through increasing cell cycle division 2 (CDC2) and CyclinB1 expression level, whereas co-culture medium with high concentration of MPP+ (500 µM) induced Jurkat cell necrosis through cellular swelling and membrane breakage. Our data implies that damaged dopamine neurons with glial cells can lead to the reduced number or inhibited proliferation activity of peripheral T cells.

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“…This finding suggests that innate immune activation occurred in association with or in response to Lewy body formation [40]. Serum levels of TNFα are elevated in PD patients and the serum levels of IL-6 correlate with Hoehn and Yahr staging [41]. Taken together, this evidence indicates that an active inflammatory process with definite innate immune involvement is ongoing in the CNS of PD patients.…”

Section: Evidence For Inflammation and Innate Immunity In Pdmentioning

confidence: 99%