Inflammatory cytokine alterations in women veterans from pregnancy to postpartum: Exploratory analyses with depression

Szpunar, Mercedes J.; Malaktaris, Anne; Baca, Selena A.; Hauger, Richard L.; Láng, András

doi:10.1016/j.bbi.2021.08.181

Cited by 1 publication

(3 citation statements)

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“…Serumal interferon-γ (IFN-γ) and the ratio of IFN-γ/IL-10 were decreased in PPD, according to Maureen W Groer et al (Groer and Morgan, 2007). Besides, the secretion of IL-8 has been reported to increase in the postpartum period (Szpunar et al, 2021). Increased plasma IL-8 or reduced IL-2 was associated with higher risk for PPD (Achtyes et al, 2020).…”

Section: Cytokinesmentioning

confidence: 98%

“…Other studies (Ahn and Corwin, 2015;Nagayasu et al, 2021) did not find the correlation between IL-6 levels and the scores of Edinburgh Postpartum Depression Scale (EPDS), depressive symptoms, or stress variables. In an exploratory study among postpartum veterans (Szpunar et al, 2021), the researchers found that elevated IL-1β and tumor necrosis factorα (TNF-α) might have a positive correlation with the severity of depressive symptom. And the high level of IL-1β was also related to suicidal thoughts during pregnancy (Szpunar et al, 2021).…”

Section: Cytokinesmentioning

confidence: 99%

“…In an exploratory study among postpartum veterans (Szpunar et al, 2021), the researchers found that elevated IL-1β and tumor necrosis factorα (TNF-α) might have a positive correlation with the severity of depressive symptom. And the high level of IL-1β was also related to suicidal thoughts during pregnancy (Szpunar et al, 2021). Similarly, other studies showed that uric or plasmic IL-1β was increased in mothers with depressive symptoms or high scores of EPDS (≥13) (Corwin et al, 2008;Sha et al, 2022).…”

Section: Cytokinesmentioning

confidence: 99%

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Inflammatory pathophysiological mechanisms implicated in postpartum depression

2022

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Postpartum Depression (PPD) is a serious psychiatric disorder of women within the first year after delivery. It grievously damages women’s physical and mental health. Inflammatory reaction theory is well-established in depression, and also has been reported associated with PPD. This review summarized the inflammatory pathophysiological mechanisms implicated in PPD, including decreased T cell activation, increased proinflammatory cytokines secretion, active kynurenine pathway, and initiated NLRP3 inflammasome. Clinical and preclinical research are both gathered. Potential therapeutical alternatives targeting the inflammatory mechanisms of PPD were introduced. In addition, this review briefly discussed the differences of inflammatory mechanisms between PPD and depression. The research of inflammation in PPD is limited and seems just embarking, which indicates the direction we can further study. As a variety of risky factors contribute to PPD collectively, therapy for women with PPD should be comprehensive, and clinical heterogeneity should be taken into consideration. As PPD has a predictability, early clinical screening and interventions are also needed. This review aims to help readers better understand the inflammatory pathological mechanisms in PPD, so as to identify biomarkers and potential therapeutic targets in the future.

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Section: Cytokinesmentioning

confidence: 98%