Inflammatory cell infiltration and resolution of kidney inflammation is orchestrated by the cold-shock protein Y-box binding protein-1

Bernhardt, Anne; Fehr, Alexander; Brandt, Sabine; Jerchel, Saskia; Ballhause, Tobias Malte; Philipsen, Lars; Stolze, Saskia; Geffers, Robert; Weng, Honglei; Fischer, Klaus–Dieter; Isermann, Berend; Brunner‐Weinzierl, Monika C.; Batra, Arvind; Siegmund, Britta; Zhu, Cheng; Lindquist, Jonathan A.; Mertens, Peter R.

doi:10.1016/j.kint.2017.03.035

Cited by 48 publications

(42 citation statements)

References 36 publications

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“…Moreover, YB-1 was phosphorylated at serine 102 localised to the fourth intron, the IL10 gene locus, which was paralleled by enhanced IL-10 mRNA expression in mice following lipopolysaccharide (LPS) challenge and I/R. Furthermore, half-maximal expression of YB-1 led to diminished IL-10 expression upon LPS challenge, consistent with the results of a previous study [6]. However, higher YB-1 expression enhanced IL-10 mRNA expression [10].…”

Section: Yb-1 and Akisupporting

confidence: 89%

“…Interestingly, half-maximal YB-1 expression results in the amelioration of AKI by inhibiting CCL5 gene expression [19]. Moreover, increased tubular cell CCL5 expression was found in conditional Ybx1 knockout animals with specific depletion in monocytes/macrophages (YB-1 ∆LysM ) [6]. Regulatory T cell-derived IL-10 plays an important renoprotective role in murine models of ischaemia-reperfusion (I/R) [24].…”

Section: Yb-1 and Akimentioning

confidence: 99%

“…YB-1 regulates proliferation, matrix protein synthesis, chemotaxis, and phenotypic alterations in monocytic cells; it is also crucially involved in the orchestration of inflammatory responses [1]. Bernhardt et al [6] revealed increased inflammatory cell infiltration and tubular cell CCL5 expression in YB-1 ∆LysM mice following tubulointerstitial injury by unilateral ureteral obstruction. Furthermore, YB-1 ∆LysM mice exhibited enhanced tissue damage, myofibroblast activation, and fibrosis.…”

Section: Yb-1 and Ckdmentioning

confidence: 99%

“…Moreover, YB-1 is a major component of messenger ribonucleoprotein particles in mammalian cells and regulates the stabilisation of mRNA and translation of mediators, such as profibrotic cytokine transforming growth factor (TGF)-β and pro-inflammatory cytokine C-C motif chemokine ligand 2 (CCL2)/monocyte chemoattractant protein 1 (MCP-1) [4, 5]. YB-1 has a prominent and distinct role in the regulation of the inflammation process [6]. YB-1 seems to fulfil a pacemaker role in diverse diseases, functioning in both inflammatory/ pro-fibrogenic and tumourigenic pathways [7].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, increasing evidence has shown that YB-1 plays a protective role in acute or chronic kidney injury [6, 10]. Furthermore, YB-1 may be involved in the pathogenesis of obesity-related kidney disease (ORKD) [11].…”

Section: Introductionmentioning

confidence: 99%

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The Role of Y-Box Binding Protein 1 in Kidney Injury: Friend or Foe?

Ke¹,

Fan²,

Tu³

et al. 2018

Cell Physiol Biochem

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Y-box-binding protein 1 (YB-1) is a multifunctional protein involved in various cellular processes via the transcriptional and translational regulation of target gene expression. YB-1 promotes acute or chronic kidney injury through multiple molecular pathways; however, accumulating evidence suggests that significantly increased YB-1 levels are of great importance in renoprotection. In addition, YB-1 may contribute to obesity-related kidney disease by promoting adipogenesis. Thus, the role of YB-1 in kidney injury is complicated, and no comprehensive review is currently available. In this review, we summarise recent progress in our understanding of the function of YB-1 in kidney injury and provide an overview of the dual role of YB-1 in kidney disease. Moreover, we propose that YB-1 is a potential therapeutic target to restrict kidney disease.

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Section: Yb-1 and Akisupporting

confidence: 89%

Section: Yb-1 and Akimentioning

confidence: 99%

Section: Yb-1 and Ckdmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Role of Y-Box Binding Protein 1 in Kidney Injury: Friend or Foe?

Ke¹,

Fan²,

Tu³

et al. 2018

Cell Physiol Biochem

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Stem Cells for Next Level Toxicity Testing in the 21st Century

Fritsche

Haarmann‐Stemmann

Kapr

et al. 2020

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Self Cite

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The call for a paradigm change in toxicology from the United States National Research Council in 2007 initiates awareness for the invention and use of human‐relevant alternative methods for toxicological hazard assessment. Simple 2D in vitro systems may serve as first screening tools, however, recent developments infer the need for more complex, multicellular organotypic models, which are superior in mimicking the complexity of human organs. In this review article most critical organs for toxicity assessment, i.e., skin, brain, thyroid system, lung, heart, liver, kidney, and intestine are discussed with regards to their functions in health and disease. Embracing the manifold modes‐of‐action how xenobiotic compounds can interfere with physiological organ functions and cause toxicity, the need for translation of such multifaceted organ features into the dish seems obvious. Currently used in vitro methods for toxicological applications and ongoing developments not yet arrived in toxicity testing are discussed, especially highlighting the potential of models based on embryonic stem cells and induced pluripotent stem cells of human origin. Finally, the application of innovative technologies like organs‐on‐a‐chip and genome editing point toward a toxicological paradigm change moves into action.

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Solid Organ Injury

Land

2020

Damage-Associated Molecular Patterns in Human Diseases

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Inflammatory cell infiltration and resolution of kidney inflammation is orchestrated by the cold-shock protein Y-box binding protein-1

Cited by 48 publications

References 36 publications

The Role of Y-Box Binding Protein 1 in Kidney Injury: Friend or Foe?

The Role of Y-Box Binding Protein 1 in Kidney Injury: Friend or Foe?

Stem Cells for Next Level Toxicity Testing in the 21st Century

Solid Organ Injury

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