Inflammatory Cell Infiltrates in Vessels With Different Susceptibility to Atherosclerosis in Rheumatic and Non-Rheumatic Patients A Controlled Study of Biopsy Specimens Obtained at Coronary Artery Surgery

Hollan, Ivana; Prayson, Richard A.; Saatvedt, Kjell; Sm, Almdahl; Nossent, Jiri; Mikkelsen, Knut; Liang, Matthew H.; Kvelstad, Ingjerd Lien; Aamodt, Geir; Førre, Ø.

doi:10.1253/circj.cj-08-0473

Cited by 29 publications

(16 citation statements)

References 41 publications

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“…10 -12 These effects may be due, in part, to direct vascular inflammation in RA. Although large-vessel vasculitis in RA is said to be rare, and clinically apparent in only 1% to 3% of patients, 13,14 histological studies in patients undergoing coronary bypass graft surgery demonstrate greater mononuclear cell infiltration within the aortic media and adventitia in patients with inflammatory rheumatic disease than controls, 15 suggesting a subclinical vasculitis. This may also explain our previous observations of increased aortic stiffness in RA, which is reversible with anti-inflammatory therapies.…”

Section: Editorial See P 2449 Clinical Perspective On P 2480mentioning

confidence: 99%

Anti-Tumor Necrosis Factor-α Therapy Reduces Aortic Inflammation and Stiffness in Patients With Rheumatoid Arthritis

et al. 2012

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Background— Rheumatoid arthritis (RA) is a systemic inflammatory condition associated with increased cardiovascular risk. This is not fully explained by traditional risk factors, but direct vascular inflammation and aortic stiffening may play a role. We hypothesized that patients with RA exhibit aortic inflammation, which can be reversed with anti-tumor necrosis factor-α therapy and correlates with aortic stiffness reduction. Methods and Results— Aortic inflammation was quantified in 17 patients with RA, before and after 8 weeks of anti-tumor necrosis factor-α therapy by using 18 F-fluorodeoxyglucose positron emission tomography with computed tomography coregistration. Concomitantly, 34 patients with stable cardiovascular disease were imaged as positive controls at baseline. Aortic fluorodeoxyglucose target-to-background ratios (TBRs) and aortic pulse wave velocity were assessed. RA patients had higher baseline aortic TBRs in comparison with patients who have cardiovascular disease (2.02±0.22 versus 1.74±0.22, P =0.0001). Following therapy, aortic TBR fell to 1.90±0.29, P =0.03, and the proportion of inflamed aortic slices (defined as TBR >2.0) decreased from 50±33% to 33±27%, P =0.03. Also, TBR in the most diseased segment of the aorta fell from 2.51±0.33 to 2.05±0.29, P <0.0001. Treatment also reduced aortic pulse wave velocity significantly (from 9.09±1.77 to 8.63±1.42 m/s, P =0.04), which correlated with the reduction of aortic TBR ( R =0.60, P =0.01). Conclusions— This study demonstrates that RA patients have increased aortic 18 F-fluorodeoxyglucose uptake in comparison with patients who have stable cardiovascular disease. Anti-tumor necrosis factor-α therapy reduces aortic inflammation in patients with RA, and this effect correlates with the decrease in aortic stiffness. These results suggest that RA patients exhibit a subclinical vasculitis, which provides a mechanism for the increased cardiovascular disease risk seen in RA.

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Section: Editorial See P 2449 Clinical Perspective On P 2480mentioning

confidence: 99%

Anti-Tumor Necrosis Factor-α Therapy Reduces Aortic Inflammation and Stiffness in Patients With Rheumatoid Arthritis

et al. 2012

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“…13 Aortic atherosclerosis is present in most patients with distal type AAD, 14 and aortic wall inflammation might be involved in athrogenesis. 15 The other is an acute phase reaction. Schillinger et al reported that elevated admission CRP levels were associated with poor prognosis in patients with AAD.…”

Section: Discussionmentioning

confidence: 99%

Reduction of the PaO2/FiO2 Ratio in Acute Aortic Dissection - Relationship Between the Extent of Dissection and Inflammation -

Kurabayashi

Okishige

Azegami

et al. 2010

Circ J

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Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp cute aortic dissection (AAD) is frequently accompanied by acute respiratory failure. This respiratory failure has been hypothesized by some investigators to be due to activation of systemic inflammatory reactions in AAD, 1-3 given that acute respiratory distress syndrome (ARDS) and its less severe form, acute lung injury (ALI), can have etiology that is systemic, rather than pulmonary, such as in disseminated intravascular coagulation. The systemic inflammatory reaction in AAD is provoked by acute aortic injury and is reflected in an increment in serum C-reactive protein (CRP), 1-4 white blood cell (WBC) count 2 and proinflammatory cytokine levels. 1 We hypothesized that some measure of the extent of aortic dissection, such as its volume, might correlate with the severity of the inflammatory response, and in turn, with respiratory function. To our knowledge, these relationships have never been studied, with the exception of one study in which inflammatory markers were shown to be higher in DeBakey type IIIb AAD than in type IIIa AAD. 2 The specific aims of our study were to identify predictors of oxygenation impairment and to assess the relationship between the incidence of respiratory failure and the extent of aortic dissection. Because proximal type AAD (DeBakey type I or II 5 ) often requires surgical intervention, which could also lead to pulmonary complications, we chose to limit our study to patients with distal type AAD (DeBakey type III 5 ). Background: Acute aortic dissection (AAD) often accompanies acute respiratory failure. The aim of this study was to clarify the relationship between the incidence of oxygenation impairment and the extent of distal type AAD. Methods Study Population

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“…The most important inflammatory cells for atherosclerosis are the monocytes that differentiate into macrophages or dendritic cells in plaque, and the T-helper and suppressor lymphocytes that coordinate the inflammatory reaction in plaque. 25 Inflammatory cells express P2RY2 with multiple effects. P2RY2 is expressed on both T lymphocytes and macrophages, and it has been suggested that is has an important role in atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Association of the Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2) Gene With Myocardial Infarction in Japanese Men

Wang

Nakayama

Sato

et al. 2009

Circ J

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Background: Atherosclerosis leads to myocardial infarction (MI) and P2RY2 plays an important role in this process. The aim of the present study was to investigate the association between human P2RY2 and MI via a haplotype-based case-control study that additionally analyzed the group by sex. Methods and Results:The 310 MI patients and 254 controls were genotyped for 5 single-nucleotide polymorphisms (SNPs) of the human P2RY2 gene (rs4944831, rs1783596, rs4944832, rs4382936, rs10898909). Data were separately analyzed for the total, male, and female subjects. For men, the GA+AA genotype of rs10898909 was significantly higher in MI patients as compared with controls (P=0.040). Logistic regression analysis found a significant difference for the genotype (P=0.016). As compared with controls, the frequencies of the C-A and T-C-A haplotypes were significantly higher (P=0.016, and P=0.045, respectively) in men, whereas the frequencies of the C-G and T-A-A haplotypes were significantly lower (P=0.023, and P=0.025, respectively) in MI patients. Conclusions: The GA+AA genotype, as well as the C-A and T-C-A haplotypes, of human P2RY2 could be genetic markers for MI in Japanese men. (Circ J 2009; 73: 2322 -2329

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Inflammatory Cell Infiltrates in Vessels With Different Susceptibility to Atherosclerosis in Rheumatic and Non-Rheumatic Patients A Controlled Study of Biopsy Specimens Obtained at Coronary Artery Surgery

Cited by 29 publications

References 41 publications

Anti-Tumor Necrosis Factor-α Therapy Reduces Aortic Inflammation and Stiffness in Patients With Rheumatoid Arthritis

Anti-Tumor Necrosis Factor-α Therapy Reduces Aortic Inflammation and Stiffness in Patients With Rheumatoid Arthritis

Reduction of the PaO2/FiO2 Ratio in Acute Aortic Dissection - Relationship Between the Extent of Dissection and Inflammation -

Association of the Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2) Gene With Myocardial Infarction in Japanese Men

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