Inflammatory breast cancers in Tunisia and France show similar immunophenotypes

Charafe-Jauffret, Emmanuelle; Mrad, Karima; Labidi, Sana Intidhar; Hamida, Azza Ben; Romdhane, Khaled Ben; Abdallah, M. Ben; Ginestier, Christophe; Esterni, Benjamin; Birnbaum, Daniel; Ayed, Farhat Ben; Xerri, Luc; Viens, Patrice; Mézlini, Amel; Jacquemier, Jocelyne

doi:10.1016/j.breast.2007.01.002

Cited by 16 publications

(11 citation statements)

References 16 publications

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“…However, study participants were selected from a large pool of non-IBC patients who were matched with IBC patients on grade and histopathological type to eliminate variables that could confound the comparisons between the 2 groups. Third, several characteristics of the IBC patients recruited in this study were consistent with previous research reports from Egyptian [10]and Tunisia nIBC cases[14, 16], suggesting that the results are not likely to be affected by selection bias. Fourth, the higher incidence of IBC in a large sample of Algerian patients provides a unique opportunity to investigate the etiology and molecular abnormalities of IBC.…”

Section: Discussionsupporting

confidence: 88%

“…Our findings of 10% of patients reporting family history of breast cancer for both IBC and non-IBC patients are in agreement with studies showing no familial link for IBC. There are some differences between Egyptian, Tunisian IBC and Algerian patients: The median age for Egyptian and Tunisian IBC patients is ~43 years old [8, 10, 14, 24], but Algerian IBC patients were older (median, 48.5 years). Furthermore, a high proportion of Egyptian IBC patients (83%) presented at diagnosis with palpable masses, high number of tumor emboli, and IBC patients typically lived in rural areas, although this last factor was not significant [24].…”

Section: Discussionmentioning

confidence: 99%

“…Environmental factors such as high fat intake [7, 8], increased exposure to exogenous hormones, pesticides and herbicides [9–11], and infectious agents such as human mammary tumor virus sequences [12, 13]are plausible etiologic factors. Genetic or molecular factors have not been fully explored in IBC; some studies showed similar immuno-phenotypes between Tunisian and French patients [14, 15], but significant differences at the expression level of P-cadherin in Tunisian versus French women [16], and RhoC expression between US and Egyptian IBC patients have been reported [10]. Of interest, IBC Egyptian patients presented more often with high number of tumor emboli and RhoC levels as compared to non-IBC cases [10].…”

Section: Introductionmentioning

confidence: 99%

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Molecular and epidemiological characteristics of inflammatory breast cancer in Algerian patients

Chaher

Arias-Pulido

Terki

et al. 2011

Breast Cancer Res Treat

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Background Inflammatory breast cancer (IBC) shows a high incidence in Tunisia and Egypt but epidemiological and molecular characteristics have not been described in Algeria. Methods We compared 117 IBC and 59 non-IBC locally advanced breast cancers (LABC), for estrogen and progesterone receptors, HER2, and EGFR protein expression by immunohistochemistry, and HER2 gene amplification by chromogenic in situ hybridization. Demographic, clinico-pathological and molecular variables were compared with chi-square and Fisher’s exact tests to test for significance (P < 0.05, two-tailed). Overall survival (OS) and disease-free survival (DFS) were plotted using Kaplan–Meier curves and compared using the log-rank test. Results Tumor emboli were detected in 77% of IBC. Palpable masses were found in all LABC but only in 32% of IBC (P<0.001). Recurrences were higher in LABC than in IBC (48% vs. 35%; P=0.14) but OS was worse in IBC (68% vs. 71%; P=0.06). There were no significant differences between IBC and LABC by demographics or by clinico-pathologic parameters. The majority of IBC and LABC tumors were luminal A (62% and 64%), followed by basal (~18%, each), triple negative (~18%, each) and HER2+ (~10%, each) subtypes. In multivariate analyses, grade was associated with worse OS (P=0.04), and DFS (P<0.001) in IBC; chemo-and radio-therapy were associated with improved OS and DFS, respectively (P<0.05 for each) in LABC. Conclusions IBC in Algeria shows similar characteristics to IBC described for Egypt and Tunisia with subtle molecular differences. Current therapeutic treatments were not very effective in this population and new approaches are much needed.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Molecular and epidemiological characteristics of inflammatory breast cancer in Algerian patients

Chaher

Arias-Pulido

Terki

et al. 2011

Breast Cancer Res Treat

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“…In the literature, the IBC are characterised by their rapid spread to lymph nodes and a high metastatic potential [2] [24] [25] [26] [28].…”

Section: ) Epidemiological Characteristics -Frequencymentioning

confidence: 99%

Management of Inflammatory Breast Cancers in Subsaharian Africa Context

Dia¹,

Djanhan²,

Saki³

et al. 2018

OJOG

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Objective: To report the experience of Gynecology Department of the University Hospital of Treichville in the management of the inflammatory breast cancers. Methodology: We conducted a retrospective and descriptive study on cases of the inflammatory breast cancers managed in the Gynecology Department of the University Hospital of Treichville, from January 2011 to December 2015. Results: We collected 44 cases of inflammatory breast cancer representing 17.9% of all breast cancers. The average age of patients was 46.5 years (32 -70 years) and among them, the majority had inadequate socioeconomic level (90.9%). The risk factor for cancer found in the majority of patients was the age of first menstrual periods before the age of 12 years (52.3%). The average consultation time was long (10 months) and several patients had extensive inflammatory signs (38.6%), with lymph node involvement (84.1%) and metastases (36.4%). At the histological analysis, the most common type was invasive ductal carcinoma (81.8%), SBR grade III (54.5%). Regarding treatment, mastectomy according to Patey associated with a chemotherapy was performed in 22.7% cases. The evolution has been marked by an overall 5-year survival of 20%. Conclusion: The management of inflammatory breast cancers was late and incomplete in our service making poor prognosis.

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“…However, there is no difference between Tunisian and French IBCs in the expression of five representative proteins (E-cadherin, Estrogen receptor (ER), MIB1, MUC1, and ERBB2) (11,12). Until 2003, no biological markers were used to define the IBC phenotype.…”

Section: Introductionmentioning

confidence: 98%

Expression of WISP3 and RhoC Genes at mRNA and Protein Levels in Inflammatory and Noninflammatory Breast Cancer in Tunisian Patients

Marrakchi¹,

Khadimallah²,

Ouerhani³

et al. 2010

Cancer Invest

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Previous studies have shown the expression WISP3 and RhoC in cell lines of inflammatory breast cancer (IBC). The aim in the current study was to compare the expression of both genes, in biopsy samples collected from Tunisian patients with localized or metastatic breast cancer and patients with IBC. We investigated 127 patients enrolled in Salah Azaiez Institute in Tunis. Using the RT-PCR, we showed the phenotype (WISP3-, RhoC+) is significantly associated with IBC tumors, while the (WISP3+, RhoC-)phenotype is mostly associated to non-IBC tumors. The frequencies of these tumor phenotypes are significantly different between these tumor groups (p = 10(- 7); relative risk or RR = 3.25; confidential interval or CI 95% = 1.90-5.53). Immunohistochemical test revealing the presence of WISP3 and RhoC proteins correlates with the expression in the biopsy of their encoding genes as detected by RT-PCR. In conclusion, it appears that WISP3 and RhoC genes expression status defines a molecular signature of IBC.

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Inflammatory breast cancers in Tunisia and France show similar immunophenotypes

Cited by 16 publications

References 16 publications

Molecular and epidemiological characteristics of inflammatory breast cancer in Algerian patients

Molecular and epidemiological characteristics of inflammatory breast cancer in Algerian patients

Management of Inflammatory Breast Cancers in Subsaharian Africa Context

Expression of WISP3 and RhoC Genes at mRNA and Protein Levels in Inflammatory and Noninflammatory Breast Cancer in Tunisian Patients

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