Inflammatory Bowel Diseases Were Associated With Risk of Sexual Dysfunction in Both Sexes: A Meta-analysis

Zhao, Shankun; Wang, Jiamin; Liu, Yangzhou; Luo, Lianmin; Zhu, Zhiguo; Li, Ermao; Luo, Jin-Yan; Zhao, Zhigang

doi:10.1093/ibd/izy345

Cited by 29 publications

(25 citation statements)

References 34 publications

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“…The included meta-analyses were published in English between 2014 and 2019. Various disease outcomes included cancers (n=7) [26][27][28][29][30][31], cardiovascular and cerebrovascular diseases (n=8) [32][33][34][35], obstetrical diseases (n=4) [36], neuropsychiatric disease (n=1) [38], otolaryngology and stomatology diseases (n=2) [41,43] and others (n=6) [37,[39][40]42,44] (Table 1). A total of 249 individual study estimates were included among the 19 articles.…”

Section: Resultsmentioning

confidence: 99%

The Associations between Inflammatory Bowel Disease and a Range of Other Diseases：Umbrella Review of Systematic Reviews and Meta-analyses

Cen

Liu

et al. 2021

Preprint

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Background Multiple meta-analyses have reported inflammatory bowel diseases (IBD) are associated with an increased risk of diverse diseases, but the evidence quality remains unclear. Objectives We aimed to summarize and evaluate this existing evidence on the associations between IBD and a range of diseases a-crossed from meta-analyses. Methods PubMed, the Cochrane Library Database, Embase, Web of Science, CNKI Databases, Wanfang Databases and VIP Database were searched to obtain eligible literatures from inception to November 1, 2019. We appraised the methodological quality of the included meta-analyses using AMSTAR 2 tool, and evaluated the quality of evidence for each outcome using the GRADE approach. Results Nineteen articles covering associations between IBD and 28 types of health outcomes were included. The methodological quality of meta-analyses was rated moderate for 5.26%, low for 21.05%, and critically low for 73.68%. Overall, summary effect estimates were significant in 26 meta-analyses. The evidence quality was rated high for 3.57%, moderate for 21.43%, low for 28.57%, and very low for 46.43%. Evidence quality was high for association between IBD and an increased periodontitis risk (OR = 4.55; 95% CI, 3.00-6.19). Evidence quality was moderate for associations between IBD and an increased thyroid cancer risk (OR = 1.75; 95% CI, 1.48–2.07), myocardial infarction incidence (RR = 1.12; 95% CI, 1.05–1.21), preterm birth incidence (OR = 1.85; 95% CI, 1.67–2.05), stillbirth incidence (OR = 1.57; 95% CI, 1.03–2.38), gallstone disease prevalence (OR = 1.72; 95% CI, 1.40–2.12), and vitamin D deficiency prevalence (OR = 1.64; 95% CI, 1.30–2.08). Conclusions Though, associations between IBD and diverse diseases have been extensively studied, few of the reported associations have robust support. Further well-designed studies are essential to determine whether IBD increases the risk of other diseases.

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Section: Resultsmentioning

confidence: 99%

The Associations between Inflammatory Bowel Disease and a Range of Other Diseases：Umbrella Review of Systematic Reviews and Meta-analyses

Cen

Liu

et al. 2021

Preprint

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“…(1.09-1.81) meaning men with IBD have a 41% higher risk of sexual dysfunction, mainly measured through erectile function, than their healthy counterparts (Zhao et al, 2019). This supports a case for further investigation but does not provide detailed insight into the concerns of men with IBD pertaining to sexual health and well-being.…”

Section: Con Clus Ionmentioning

confidence: 95%

“…Both men and women have an increased risk of sexual dysfunction in IBD (Zhao et al, 2019). Previous literature reviews have identified that disease activity, medications, surgery and poor perception of body image all lead to a negative impact upon sexual health (Giese & Terrell, 1996;Jedel, Hood, & Keshavarzian, 2015;Mantzouranis, Fafliora, Glanztounis, Christodoulou, & Katsanos, 2015).…”

Section: Introductionmentioning

confidence: 99%

The impact of inflammatory bowel disease on sexual health in men: A scoping review

Veysey

Ersser

et al. 2020

Journal of Clinical Nursing

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Aims and objectives To review the literature on the impact of inflammatory bowel disease on the sexual health of men and make recommendations for nursing practice and research. Background Inflammatory bowel disease is a chronic condition of the gastrointestinal tract, causing symptoms that may impact upon sexual health. Specialist nurses are well positioned to assess and manage sexual health, but there is a lack of clinical guidance, especially in relation to men. Design A systematic scoping review following the Arksey and O’Malley (International Journal of Social Research Methodology, 8, 2005, 19) framework reported in line with the PRISMA‐ScR checklist (Tricco et al., Annals of Internal Medicine, 169, 2018, 467). Methods OVID MEDLINE ALL [R], OVID EMBASE [R], OVID PsychINFO, EBSCO CINAHL Complete, The Cochrane Library and ProQuest were searched. Inclusion and exclusion criteria were applied independently by two reviewers. Data were extracted, charted and summarised from eligible studies. Results Thirty‐one studies met the inclusion criteria. These were synthesised under three categories: mediators, moderators and descriptors of sexual health. Depression, disease activity and surgery were the most commonly cited disease‐related factors to affect sexual health in men. The most commonly used assessment tool was The International Index of Erectile Function. Descriptors of function included frequency of intercourse, libido and the ability to maintain a desired sexual role. Conclusions The effect of inflammatory bowel disease on sexual health in men involves a complex interaction of physical and psychosocial factors. Researchers must explore areas outside of erectile function to understand how the disease impacts sexuality, sexual well‐being and masculinity. This can be achieved through qualitative exploration of patient, partner and health professional experiences. Relevance to clinical practice A holistic nursing assessment of men with inflammatory bowel disease should include sexual health. Developing understanding of how the disease influences sexual interaction and expression will facilitate support that is relevant, accessible and of value to men living with the disease.

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“…QoL and patient-related outcomes are the treatment targets for managing patients who are suffering from inflammatory bowel disease (IBD)[2]. Sexual health is a main determinant of QoL and is negatively impacted in patients with IBD[3,4]. IBD patients expect more open listening and better information from care providers[5].…”

Section: Introductionmentioning

confidence: 99%

Sexual health and fertility for individuals with inflammatory bowel disease

Leenhardt¹,

Rivière²,

Papazian³

et al. 2019

WJG

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The impact of a chronic disease such as inflammatory bowel disease (IBD) on sexual functioning and body image can significantly impair the quality of life of patients. This review considers the sexual and fertility aspects of IBD patients and their daily management. Modern IBD healthcare management should include appropriate communication on sexuality and consider psychological, physiological, and biological issues. Patients with IBD have less children than the general population, and voluntary childlessness is frequent. The most influential factors reported by IBD patients who experience fertility alteration are psychological and surgery-related problems. Pregnancy is a major concern for patients, and any pregnancy for IBD patients should be closely followed-up to keep the chronic disease in a quiescent state. Preconceptional consultation is of great help.

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Inflammatory Bowel Diseases Were Associated With Risk of Sexual Dysfunction in Both Sexes: A Meta-analysis

Cited by 29 publications

References 34 publications

The Associations between Inflammatory Bowel Disease and a Range of Other Diseases：Umbrella Review of Systematic Reviews and Meta-analyses

The Associations between Inflammatory Bowel Disease and a Range of Other Diseases：Umbrella Review of Systematic Reviews and Meta-analyses

The impact of inflammatory bowel disease on sexual health in men: A scoping review

Sexual health and fertility for individuals with inflammatory bowel disease

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