Inflammatory Bowel Diseases: Pathogenesis

Ananthakrishnan, Ashwin N.; Xavier, Ramnik J.; Podolsky, Daniel K.

doi:10.1002/9781118512074.ch70

Cited by 3 publications

(4 citation statements)

References 162 publications

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“…However, the pathogenesis of IBD remains unclear due to lack of investigation. IBD is a multifactorial disorder induced by the interaction of genetic factors, environment, microbiota, and immune response, which are involved in pathogenesis [4,5]. Recently, many studies have indicated that the breakdown of homeostasis among the immune system, epithelial barrier, and gut microbiome might be the critical underlying mechanism responsible for the development of IBD [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…IBD is a multifactorial disorder induced by the interaction of genetic factors, environment, microbiota, and immune response, which are involved in pathogenesis [4,5]. Recently, many studies have indicated that the breakdown of homeostasis among the immune system, epithelial barrier, and gut microbiome might be the critical underlying mechanism responsible for the development of IBD [4,5]. Previous reports suggested that the products of gut microbiota could positively have an effect on the pathogenesis of inflammation-associated diseases [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Dietary Supplementation with Sea Bass (Lateolabrax maculatus) Ameliorates Ulcerative Colitis and Inflammation in Macrophages through Inhibiting Toll-Like Receptor 4-Linked Pathways

Chen

Jayachandran

Zhang

et al. 2019

IJMS

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Sea bass (Lateolabrax maculatus) is a kind of food material commonly consumed in daily life. In traditional Chinese medicinal books, it has been indicated that sea bass can be applied for managing many inflammation-associated conditions. However, the studies on the pharmacological mechanisms of inflammation of sea bass remain scarce. Hence, this study aims to investigate the molecular mechanisms of the anti-inflammatory activity of sea bass. Anti-inflammatory activities of sea bass were assessed using dextran sulfate sodium (DSS)-induced colitis in a mice model and lipopolysaccharide (LPS)-activated macrophages model. Low body weight and short colon length were observed in DSS-fed mice that were significantly recovered upon sea bass treatments. Moreover, the colon histopathology score showed that sea bass-treated mice had decreased crypt damage, focal inflammation infiltration and the extent of inflammation, suggesting that treatment with sea bass could attenuate intestinal inflammation. In addition, the in-vitro study conjointly indicated that sea bass could suppress the inflammatory mediators in LPS-activated macrophage by inhibiting the TLR4-linked pathway. The present findings demonstrated that sea bass has an inhibitory effect on TLR4 signaling; thus, it could be a promising candidate for treating inflammation-associated conditions. A further justification for the clinical application of sea bass in treating inflammation-associated conditions is necessary.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dietary Supplementation with Sea Bass (Lateolabrax maculatus) Ameliorates Ulcerative Colitis and Inflammation in Macrophages through Inhibiting Toll-Like Receptor 4-Linked Pathways

Chen

Jayachandran

Zhang

et al. 2019

IJMS

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“…In UC patients, the colon is influenced by the excess and inappropriate responses of the immune system and limited inflammation to the colon . Although the etiology of UC is still unknown, the interaction between three important factors known as genetic, immune system, and the environment is of high importance in the development of colitis . In a person who is genetically subjected to UC, magnified T‐cell response against luminal bacteria as environmental factors with elevation in initiating inflammatory cascade .…”

Section: Introductionmentioning

confidence: 99%

Association study between two polymorphisms of tumor necrosis factor ligand superfamily member 15 (TNFSF15) gene and ulcerative colitis in south‐west of Iran

Taheri

Ghandil

Hashemi

et al. 2018

J of Cellular Biochemistry

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Background and aims Ulcerative colitis (UC) is the most prevalent clinical manifestation of the inflammatory bowel disease (IBD). Several candidate genes have been suggested to be involved in the genetic susceptibility or resistance in the development of UC. Among them, tumor necrosis factor ligand superfamily member 15 (TNFSF15) have been reported in association with IBD in several studies. The aim of this study was to investigate the association of TNFSF15 gene polymorphisms located in the promoter region, including rs6478108 (G/A −9706) and rs3810936 (G/A −15524) in Iranian patients with UC. Methods In this way, the two single nucleotide polymorphisms were studied in 115 patients with UC and 115 healthy controls with the same ethnic group from south‐west of Iran. The genomic DNA of samples was genotyped using TaqMan Real‐time PCR assay. This case‐control study was conducted at the Department of Immunology, Jundishapur University of Medical Sciences, Ahvaz, Iran. Results and conclusion Our results did not confirm the formerly reported association of the studied polymorphisms with UC disease in comparison with healthy controls, neither with the type of the clinical forms of Colitis in the studied Iranian population. Comparing the genotype frequency of single nucleotide polymorphism (SNP) rs6478108, wild‐type homozygous and heterozygote and mutant homozygote were 33%, 55.7%, and 11.3% in cases vs. 34.8%, 50.4%, and 14.8% in the controls (P = 0.6). The genotype frequency of SNP rs3810936 were 20.9%, 40.9%, and 38.2% in the cases compared to 18.3%, 44.3%, and 37.4% in controls, which was not significant ( P = 0.8). As multiple ethnic groups reside in all around the country, further studies using different ethnicities and/or larger sample size are required to clarify the role of these polymorphisms in the genetic susceptibility of UC in Iranian populations.

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“…Although Crohn's disease is a global health problem [ 5 ], its pathology remains poorly understood [ 1 , 6 ]. Nevertheless, it has been established that its etiology is associated with complex interactions between environmental, immune, microbial, and genetic factors [ 4 , 7 ], though a number of authors have suggested that the primary defect in Crohn's disease is one of relative immunodeficiency [ 6 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Systems Pharmacological Approach of Pulsatillae Radix on Treating Crohn’s Disease

Suh

2017

Evidence-Based Complementary and Alternative Medicine

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In East Asian traditional medicine, Pulsatillae Radix (PR) is widely used to treat amoebic dysentery and renowned for its anti-inflammatory effects. This study aimed to confirm evidence regarding the potential therapeutic effect of PR on Crohn's disease using a system network level based in silico approach. Study results showed that the compounds in PR are highly connected to Crohn's disease related pathways, biological processes, and organs, and these findings were confirmed by compound-target network, target-pathway network, and gene ontology analysis. Most compounds in PR have been reported to possess anti-inflammatory, anticancer, and antioxidant effects, and we found that these compounds interact with multiple targets in a synergetic way. Furthermore, the mRNA expressions of genes targeted by PR are elevated significantly in immunity-related organ tissues, small intestine, and colon. Our results suggest that the anti-inflammatory and repair and immune system enhancing effects of PR might have therapeutic impact on Crohn's disease.

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Inflammatory Bowel Diseases: Pathogenesis

Cited by 3 publications

References 162 publications

Dietary Supplementation with Sea Bass (Lateolabrax maculatus) Ameliorates Ulcerative Colitis and Inflammation in Macrophages through Inhibiting Toll-Like Receptor 4-Linked Pathways

Dietary Supplementation with Sea Bass (Lateolabrax maculatus) Ameliorates Ulcerative Colitis and Inflammation in Macrophages through Inhibiting Toll-Like Receptor 4-Linked Pathways

Association study between two polymorphisms of tumor necrosis factor ligand superfamily member 15 (TNFSF15) gene and ulcerative colitis in south‐west of Iran

Systems Pharmacological Approach of Pulsatillae Radix on Treating Crohn’s Disease

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