Inflammatory bowel diseases increase future ischemic stroke risk: A Taiwanese population-based retrospective cohort study

Huang, Wei-Shih; Tseng, Chun-Hung; Chen, Pei–Chun; Tsai, Chon‐Haw; Lin, Cheng‐Li; Sung, Fung‐Chang; Kao, Chia‐Hung

doi:10.1016/j.ejim.2014.05.009

Cited by 37 publications

(42 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After the full-text screening of the remaining 37 articles, 11 were further excluded because (1) no available RRs or SMRs with 95% CIs were reported ( n = 5), 35–39 (2) studies conducted in the same population with newer data were available ( n = 6). 40–45 Manually checking the reference lists of relevant articles yielded one additional article. Thus, a total of 27 articles 5,8–33 was included in the final analysis (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Inflammatory bowel disease and cardiovascular disease incidence and mortality: A meta-analysis

Sun

Tian

2018

Eur J Prev Cardiolog

View full text Add to dashboard Cite

Background: The risk of cardiovascular disease occurrence and death in inflammatory bowel disease patients is still unclear. Design: Meta-analysis. Methods: Pertinent studies were identified by searching articles in PubMed and Web of Knowledge to December 2017 and reviewing the reference lists of the retrieved articles. We used the fixed-effect model to pool the study-specific estimates when there was no indication of heterogeneity; otherwise, the random-effect model was used. Results: A total of 27 articles was included, of which 11 studies reported the risk of cardiovascular disease incidence and 16 studies reported the risk of cardiovascular disease death. The pooled relative risks were 1.25 (95% confidence interval (CI): 1.08, 1.44), 1.17 (95% CI: 1.07, 1.27) and 1.12 (95% CI: 1.05, 1.21) for cerebrovascular disease, coronary heart disease and myocardial infarction, respectively. In particular, the pooled relative risk was much higher in females. The pooled standardized mortality ratios were 1.01 (95% CI: 0.90, 1.14) for Crohn's disease patients and 0.93 (95% CI: 0.86, 1.01) for ulcerative colitis patients with low heterogeneity across studies. No publication bias was detected. Conclusions: There was a positive association between inflammatory bowel disease and higher risk of cardiovascular disease incidence, particularly in females. Such an association was not observed for cardiovascular disease mortality.

show abstract

Section: Resultsmentioning

confidence: 99%

Inflammatory bowel disease and cardiovascular disease incidence and mortality: A meta-analysis

Sun

Tian

2018

Eur J Prev Cardiolog

View full text Add to dashboard Cite

show abstract

“…A population-based retrospective cohort study exhibited a tendency for increased risk for ischemic stroke in IBD patients. The hazard ratio (HR) of ischemic stroke was 1.12 (95% CI 1.02–1.23) among the IBD group versus the non-IBD group [75]. The stratified HR of ischemic stroke was 1.15 (95% CI 1.04–1.28) in CD patients and 1.01 (95% CI 0.84–1.21) in UC patients.…”

Section: Ischemic Stroke In Ibdmentioning

confidence: 99%

Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke

Zhao¹,

Xiong²,

Stary³

et al. 2018

J Neuroinflammation

View full text Add to dashboard Cite

Emerging evidence suggests that gut-brain-microbiota axis (GBMAx) may play a pivotal role linking gastrointestinal and neuronal disease. In this review, we summarize the latest advances in studies of GBMAx in inflammatory bowel disease (IBD) and ischemic stroke. A more thorough understanding of the GBMAx could advance our knowledge about the pathophysiology of IBD and ischemic stroke and help to identify novel therapeutic targets via modulation of the GBMAx.

show abstract

“…The inflammatory cascade that increases risk of VTE likely also places patients with IBD at increased risk of heart failure [59] and atrial fibrillation [60] during periods of disease activity. Flares of disease are also associated with increased risk of myocardial infarction, stroke [61], and cardiovascular death [62]. A recent meta-analysis concluded that patients with IBD are at increased risk of ischaemic heart disease, but not of cardiovascular mortality [57].…”

Section: Comorbiditiesmentioning

confidence: 99%

The Changing Phenotype of Inflammatory Bowel Disease

Moran

Sheehan

Shanahan

2016

Gastroenterology Research and Practice

View full text Add to dashboard Cite

It is widely known that there have been improvements in patient care and an increased incidence of Inflammatory Bowel Disease (IBD) worldwide in recent decades. However, less well known are the phenotypic changes that have occurred; these are discussed in this review. Namely, we discuss the emergence of obesity in patients with IBD, elderly onset disease, mortality rates, colorectal cancer risk, the burden of medications and comorbidities, and the improvement in surgical treatment with a decrease in surgical rates in recent decades.

show abstract

Inflammatory bowel diseases increase future ischemic stroke risk: A Taiwanese population-based retrospective cohort study

Cited by 37 publications

References 33 publications

Inflammatory bowel disease and cardiovascular disease incidence and mortality: A meta-analysis

Inflammatory bowel disease and cardiovascular disease incidence and mortality: A meta-analysis

Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke

The Changing Phenotype of Inflammatory Bowel Disease

Contact Info

Product

Resources

About