Inflammatory bowel disease: role of diet, microbiota, life style

Neuman, Manuela G.; Nanau, Radu M.

doi:10.1016/j.trsl.2011.09.001

Cited by 136 publications

(91 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ulcerative colitis (UC), characterized by permanent mucosal inflammatory processes, presents with remission and activating periods (1). Although some environmental and genetic causes are attributed to UC progression, the exact cause of the disease is still unclear (1,2).…”

Section: Introductionmentioning

confidence: 99%

The relation between Helicobacter pylori and ulcerative colitis

Caner¹,

Altınbaş²,

Yeşil³

et al. 2014

Turk J Med Sci

View full text Add to dashboard Cite

IntroductionUlcerative colitis (UC), characterized by permanent mucosal inflammatory processes, presents with remission and activating periods (1). Although some environmental and genetic causes are attributed to UC progression, the exact cause of the disease is still unclear (1,2). In the recent years, investigators have focused on some pathogens as causes of UC (3,4).Helicobacter pylori, a pathogen related to chronic gastritis and peptic ulcers, is colonized mainly in the antrum, protecting itself from hyperacidity (5,6). Almost half of the underdeveloped populations are infected by H. pylori. Apart from the gastrointestinal system disorders, H. pylori is also found to be related to several skin diseases, autoimmune disorders, and iron deficiency (7,8). The association between H. pylori and UC is controversial. Some researchers reported that incidence of H. pylori is lower in UC patients than in healthy populations (9-12). Possible causes of this low rate of H. pylori in UC patients are the immunopathological characteristics of UC and the medications used in UC, such as 5-aminosalicylic acid (5-ASA) and antibiotics (9-12).We investigated the incidence of H. pylori in individuals with UC and determined the impact of several characteristics of UC, including extent and severity of UC, on the incidence of H. pylori. Materials and methodsPatients who were diagnosed with colitis and admitted to the outpatient gastroenterology clinic of Numune Training and Research Hospital were included in the study. Specifically, 49 patients with UC who had undergone upper gastrointestinal endoscopy with various indications were included in the study. The presence of H. pylori was assessed by taking one biopsy from the antrum in each patient. Patients using antacids or antibiotics in the previous 2 months or who had previously undergone H. pylori eradication treatment were excluded from the study. Prior to the study, all UC patients were required to provide an informed consent form and the study design was submitted to local ethics committee for approval.The density of the colonization of H. pylori was assessed by using Sydney classification (13). The demographic data of the patients in each group were obtained from the Background/aim: Besides some genetic explanations of the native course of ulcerative colitis (UC), the most attributable factors are pathogenic bacterial agents. There are some conflicting data about the relationship between Helicobacter pylori and the rate of UC in the literature. Therefore, we aimed to investigate the rate of H. pylori in UC patients.Materials and methods: Forty-nine individuals diagnosed with UC who had undergone upper gastrointestinal tract endoscopy for different reasons were included in the study. The presence of H. pylori in the stomach was checked by histopathological examination.Results: H. pylori positivity was present in 57.1% of patients with UC. Interestingly, H. pylori positivity was lower (11.1%) in pancolitis patients compared to those presenting with more limited illnesses. There wer...

show abstract

Section: Introductionmentioning

confidence: 99%

The relation between Helicobacter pylori and ulcerative colitis

Caner¹,

Altınbaş²,

Yeşil³

et al. 2014

Turk J Med Sci

View full text Add to dashboard Cite

show abstract

“…Although the precise aetiology of CD, as well as the forces behind the changing epidemiology, remain unknown, most hypotheses propose that environmental factors are the predominant contributing force in the rise of CD rates and earlier disease onset [19,49,50] . The changing diet habits of Asian populations is one factor that may be responsible for the rising incidence [34,51] .…”

Section: Role Of Environmental Factors In CD Pathogenesis and Changinmentioning

confidence: 99%

Changing Patterns in the Epidemiology of Crohn Disease

Alhagamhmad

Leach

Lemberg

et al. 2015

Journal of Gastroenterology and Hepatology Research

View full text Add to dashboard Cite

Crohn disease is a chronic inflammatory disorder that primarily affects the alimentary tract. It is an increasingly global health concern, with recent data indicating rising rates across many countries in the world, along with a growing prevalence in childhood. Numerous reports indicate that Crohn disease is no longer confined to Western countries, with many reports of diagnosis in other regions including less developed nations. Changes in dietary patterns, along with other environmental factors, appear to account for these recent changes in the patterns of Crohn disease epidemiology. The objective of this work was to review current available literature concerning the epidemiology of Crohn disease and to consider the possible roles of environmental factors that may be implicated in these changing patterns. Widespread data indicates increasing incidence of Crohn disease in many countries across the world. The reasons for these rapid changes in the epidemiology of Crohn disease are not clearly understood. However, environmental changes appear to the most important factors for these recent changes.

show abstract

“…Although some environmental and genetic causes are attributed to UC progression, the exact cause of the disease is still unclear (1,2). In the recent years, investigators have focused on some pathogens as causes of UC (3,4).…”

Section: Introductionmentioning

confidence: 99%

Effects of osteocytes on vibration-induced reflex muscle activity in postmenopausal women

Karamehmetoglu¹,

Karacan²,

Çidem³

et al. 2014

Turk J Med Sci

View full text Add to dashboard Cite

IntroductionWhole-body vibration (WBV), as a method of exercise training, is becoming increasingly popular in physical therapy, rehabilitation, and professional sports, and is increasingly used in beauty and wellness applications due to its beneficial effects on the neuromusculoskeletal system. These benefits include the enhancement or improvement of strength and power of muscles, balance coordination, and bone mass, or at least the prevention of loss of strength and power of muscles, balance coordination, and bone mass (1-4).Little is known about the physiological mechanisms underlying the effects of WBV on neuromuscular performance, although the presence of reflex muscle activity during WBV has been shown (4,5). The "tonic vibration reflex" (TVR) is the most commonly cited mechanism to explain the effects of WBV on neuromuscular performance, although there is no conclusive evidence that TVR occurs (4-6). In locally applied vibration studies, it has been reported that direct vibration applied to a muscle or tendon stimulates muscle spindles, causing TVR to occur. As highlighted by these studies, muscle spindle discharges are sent to the motoneurons through Group Ia afferents during muscle or tendon vibration. There, they activate reflex arcs that cause the muscle to contract (3,4,6,7). However, it has been reported that the sensitivity of the muscle spindle decreases or does not increase and that presynaptic inhibition occurs in Group Ia afferent fibers with vibration (6,(8)(9)(10)(11)(12)(13)(14).The bone myoregulation reflex (BMR) is another neurological mechanism used to explain the effects of vibration on neuromuscular performance. BMR is a reflex mechanism in which osteocytes exposed to cyclic mechanical loading induce muscle activity. Osteocytes Background/aim: To assess whether osteocytes have an effect on reflex myoelectrical activity during whole-body vibration (WBV) in postmenopausal women. Materials and methods:Participants were classified into 2 groups: the low bone mineral density (BMD) group (n = 37) and normal BMD group (n = 43). Hip BMD was measured using dual-energy X-ray absorptiometry. Surface electromyography data recorded from the adductor longus muscle were processed to obtain vibration-induced reflex myoelectrical activity. Changes in plasma sclerostin (SOST) levels with WBV were expressed as a standardized vibration-induced SOST index. Results:The standardized vibration-induced SOST index was 1.03 ± 0.24 in the low BMD group and 0.99 ± 0.33 in the normal BMD group. For plasma SOST levels, no group-by-time interaction was found. The resting myoelectrical activities of adductor muscles increased significantly during WBV in both groups. However, there was no significant difference in the main effects of WBV on resting myoelectrical activity between the groups. The standardized vibration-induced plasma SOST index was found to be a significant independent predictor of the standardized vibration-induced reflex myoelectrical activity of the adductor muscle in both groups. Conclusion:This study s...

show abstract

Inflammatory bowel disease: role of diet, microbiota, life style

Cited by 136 publications

References 48 publications

The relation between Helicobacter pylori and ulcerative colitis

The relation between Helicobacter pylori and ulcerative colitis

Changing Patterns in the Epidemiology of Crohn Disease

Effects of osteocytes on vibration-induced reflex muscle activity in postmenopausal women

Contact Info

Product

Resources

About