Inflammatory Bowel Disease: Pathophysiology, Treatment, and Disease Modeling

Jang, Jiryeon; Jeong, Sehoon

doi:10.1007/s13206-023-00118-y

Cited by 4 publications

(2 citation statements)

References 187 publications

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“…Its global incidence and prevalence are rising, even in newly industrialized countries (3). Although the exact etiology is unclear, it is believed to involve a complex interplay of genetic, environmental, and immune factors (4).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Protective and Healing Effects of Heracleum lasiopetalum Boiss on a Modified Acetic Acid-Induced Ulcerative Colitis Model in Rats

Malekshahi,

Bahrami,

Babaei

et al. 2024

Jundishapur J Nat Pharm Prod

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Background: Ulcerative colitis (UC), a chronic inflammatory condition of the colon with no definitive cure, necessitates the exploration of innovative therapies. Herbal remedies combined with conventional drugs may offer complementary benefits, enhancing treatment outcomes. Objectives: This study investigates the therapeutic effects of Heracleum lasiopetalum Boiss in a rat model of acetic acid-induced UC. Methods: Forty-eight adult female Wistar rats were randomly allocated to six groups (n = 8 per group) for each of two experiments. UC was induced by intracolonic administration of 1 ml of 4% acetic acid for 10 minutes. In the treatment groups, female rats received an oral gavage of 5%, 10%, and 40% aqueous plant extract, sulfasalazine (100 mg/kg), and distilled water for 6 days, starting 3 days after acetic acid administration. The protective groups received substances via oral gavage from 7 days before to 3 days after acetic acid administration. The extent of mucosal ulcers, hyperemia, inflammation, and mucosal bleeding was evaluated based on the Gerald Classification System Score (Macroscopic). Pathological assessment was conducted on prepared slides using the modified Wallace method (Microscopic). Changes in body and colon weight, along with food and water intake, were examined. Results: Significant changes in food intake were observed in both the extract and positive control treatment groups, exhibiting a notable difference compared to the negative control group (P < 0.05). Body weight changes experienced a significant increase in the positive control treatment group compared to the negative control group (P < 0.05), while no significant difference was evident between the extract and negative control treatment groups (P > 0.05). In terms of water and food intake, as well as weight changes, no significant differences were detected among the various protective groups (P > 0.05). Both microscopic and macroscopic examinations revealed a substantial enhancement in the colon of the extract and positive control treatment groups compared to the negative control group (P < 0.05), with no significant difference observed between the protective groups (P > 0.05). Conclusions: Heracleum lasiopetalum extract demonstrates a dose-dependent reduction in colon hyperemia, mucosal ulceration, inflammation, and fibrosis. This highlights its potential as a supplementary treatment option for UC, emphasizing the need for further investigation.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Protective and Healing Effects of Heracleum lasiopetalum Boiss on a Modified Acetic Acid-Induced Ulcerative Colitis Model in Rats

Malekshahi,

Bahrami,

Babaei

et al. 2024

Jundishapur J Nat Pharm Prod

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“…4 These differences underscore the importance of understanding the molecular underpinnings of IBD within specific populations. 5 While numerous studies have explored the clinical aspects of IBD, there is a growing need to investigate the underlying genetic and genomic factors contributing to the disease's pathogenesis.…”

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confidence: 99%

Differential Gene Expression Profiles in Inflammatory Bowel Disease Patients from Kurdistan, Iraq

Mohammed,

Amin

2024

Sultan Qaboos Univ Med J

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Objectives: Inflammatory bowel disease, generally comprising Crohn's disease (CD) and ulcerative colitis (UC), has become a significant global public health concern in the last decade. The present study aimed to determine the alterations of the whole genomic expression profile among patients with inflammatory bowel disease. This study was conducted to provide the expression profile of IBD patients for the first time in this geographic location, as there are very few articles in the literature addressing this specific aspect. Methods: A study conducted in Erbil province, Kurdistan region of Iraq, from July 2021 to July 2022 compared the genome expression profiles of 10 patients with inflammatory bowel diseases to their matched controls. The sequences used in the design of this array were selected from GenBank®, dbEST, and RefSeq, Whole blood RNA extracted and hybridization on GeneChip® human genome U133A 2.0. The Scanner 3000 was used for the scanning high-resolution image and operating software (GCOS) was used for reading the results. Results: Shared upregulated genes between ulcerative colitis (UC) and Crohn's disease (CD) were (RIT2, BCL2L1, MDM2, and FKBP8) while shared downregulated genes were (NFKBIB, DDX24, and RASA3). Conclusions: Upregulated and downregulated gene expression patterns are detected in individuals with inflammatory bowel disease, offering diagnostic potential and opportunities for treatment by targeting the associated pathways. Keywords: Crohn’s disease, Expression, Erbil, Gene, Ulcerative colitis.

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Gut bacterial quorum sensing molecules and their association with inflammatory bowel disease: Advances and future perspectives

Markus

2024

Biochemical and Biophysical Research Communications

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Inflammatory Bowel Disease: Pathophysiology, Treatment, and Disease Modeling

Cited by 4 publications

References 187 publications

Evaluation of the Protective and Healing Effects of Heracleum lasiopetalum Boiss on a Modified Acetic Acid-Induced Ulcerative Colitis Model in Rats

Evaluation of the Protective and Healing Effects of Heracleum lasiopetalum Boiss on a Modified Acetic Acid-Induced Ulcerative Colitis Model in Rats

Differential Gene Expression Profiles in Inflammatory Bowel Disease Patients from Kurdistan, Iraq

Gut bacterial quorum sensing molecules and their association with inflammatory bowel disease: Advances and future perspectives

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