Inflammatory bowel disease on the risk of acute pancreatitis: A population‐based cohort study

Chen, Yu-Tso; Su, Jiann-Sheng; Tseng, Chih‐Wei; Chen, Chia-Chang; Lin, Cheng‐Li; Kao, Chia‐Hung

doi:10.1111/jgh.13171

Cited by 33 publications

(42 citation statements)

References 18 publications

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“…UC patients are reported to be at an increased risk of developing acute pancreatitis compared to the general population[31]. According to a study performed in 2003, the annual incidence of acute pancreatitis in South Korea was 19.4 per 100000 persons[32].…”

Section: Discussionmentioning

confidence: 99%

“…It is interesting that two cases of AIP occurred before the diagnosis of UC. There have been several reports of AIP occurring before the diagnosis of CD[31,32,39,40], but to the best of our knowledge, there have been no reports of AIP that preceded UC. Our results suggest that patients with repeated episodes of unexplained acute pancreatitis should be evaluated for inflammatory bowel disease.…”

Section: Discussionmentioning

confidence: 99%

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Clinical course of ulcerative colitis patients who develop acute pancreatitis

Kim

Hwang

Park

et al. 2017

WJG

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AIMTo investigate the clinical course of ulcerative colitis (UC) patients who develop acute pancreatitis.METHODSWe analyzed 3307 UC patients from the inflammatory bowel disease registry at Asan Medical Center from June 1989 to May 2015. The clinical course of UC patients who developed acute pancreatitis was compared with that of non-pancreatitis UC patients.RESULTSAmong 51 patients who developed acute pancreatitis, 13 (0.40%) had autoimmune, 10 (0.30%) had aminosalicylate-induced, and 13 (1.73%) had thiopurine-induced pancreatitis. All 13 patients with autoimmune pancreatitis (AIP) had type 2 AIP. Two (15.4%) patients had pre-existing AIP, and three (23.1%) patients developed AIP and UC simultaneously. Compared to non-pancreatitis patients, AIP patients had UC diagnosed at a significantly younger age (median, 22.9 years vs 36.4 years; P = 0.001). AIP and aminosalicylate-induced pancreatitis patients had more extensive UC compared to non-pancreatitis patients. All patients with pancreatitis recovered uneventfully, and there were no recurrences. Biologics were used more frequently in aminosalicylate- and thiopurine-induced pancreatitis patients compared to non-pancreatitis patients [adjusted OR (95%CI), 5.16 (1.42-18.67) and 6.90 (1.83-25.98), respectively]. Biologic utilization rate was similar among AIP and non-pancreatitis patients [OR (95%CI), 0.84 (0.11-6.66)]. Colectomy rates for autoimmune, aminosalicylate-induced, and thiopurine-induced pancreatitis, and for non-pancreatitis patients were 15.4% (2/13), 20% (2/10), 15.4% (2/13), and 7.3% (239/3256), respectively; the rates were not significantly different after adjusting for baseline disease extent.CONCLUSIONPancreatitis patients show a non-significant increase in colectomy, after adjusting for baseline disease extent.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical course of ulcerative colitis patients who develop acute pancreatitis

Kim

Hwang

Park

et al. 2017

WJG

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“…10 AP may be the initial extraintestinal manifestation of a systemic illness such as inflammatory bowel disease. A study conducted by Chen et al 11 found that AP preceded the diagnosis of IBD in more than 2% of patients.…”

Section: When To Suspect Pancreatitismentioning

confidence: 99%

An Update on Pediatric Pancreatitis

Shukla-Udawatta¹,

Madani²,

Kamat³

2017

Pediatr Ann

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There has been a rise in the incidence and number of admissions of children with pancreatitis over the past 20 years. Current management practices for pancreatitis in children are adapted from standards of care for adults, and there are a lack of multicenter, prospective research studies on pancreatitis in children. There are inherent differences in the clinical presentation and natural course of pancreatitis between adults and children. This review focuses on the current understanding of the epidemiology, etiologies, evaluation, and management of children with pancreatitis. [Pediatr Ann. 2017;46(5):e207-e211.].

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“…Уровень заболеваемости составил 4,3% и 2,1% соответствен но [49]. Кроме того, в популяционном когортном ис следовании на Тайване общая частота ОП была в 3,56 раза выше у пациентов с ВЗК по сравнению с пациентами без ВЗК [11]. Предполагают, что ВЗК, проявляющийся ОП, более распространен среди пе диатрической популяции с ВЗК, чем у взрослых с ВЗК.…”

Section: опunclassified

“…Этиология В патогенез ОП при ВЗК включен широкий спектр механизмов (табл. 2, 3 [5,11,49,75]). Желчные кам ни и лекарственные препараты являются наиболее распространенными причинами ОП при ВЗК; эндо скопическая ретроградная холангиопанкреатогра фия, баллонная энтероскопия, гиперкальциемия и гипертриглицеридемия как причины ОП встреча ются реже [46].…”

Section: опunclassified

Pancreatic involvement in inflammatory bowel disease: a review

Fousekis

Theopistos

Katsanos

et al. 2019

Bul. of the Club of Pancr.

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Inflammatory bowel disease (IBD) is a multisystemic disease, and pancreatic manifestations of IBD are not uncommon. The incidence of several pancreatic diseases in Crohn’s disease and ulcerative colitis is more frequent compared to the general population. Pancreatic manifestations in IBD include a wide heterogenic group of disorders and abnormalities of the pancreas and range from mild self-limited diseases to severe disorders. Acute pancreatitis, chronic pancreatitis, autoimmune pancreatitis, pancreatic autoantibodies, exocrine pancreatic insufficiency and asymptomatic imaging and laboratory abnormalities are included in related-IBD pancreatic manifestations. Involvement of the pancreas in IBD may be the result of IBD itself or of medications used.

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Inflammatory bowel disease on the risk of acute pancreatitis: A population‐based cohort study

Abstract: IBD is a risk factor for acute pancreatitis.

Cited by 33 publications

References 18 publications

Clinical course of ulcerative colitis patients who develop acute pancreatitis

Clinical course of ulcerative colitis patients who develop acute pancreatitis

An Update on Pediatric Pancreatitis

Pancreatic involvement in inflammatory bowel disease: a review

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