Inflammatory Bowel Disease in Pregnancy

Meyers, Abigail J.; Kane, Sunanda V.

doi:10.1007/978-3-031-14744-9_53

Cited by 2 publications

(3 citation statements)

References 94 publications

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“…In Northern Italy, the average incidence of IBD registered in the period 2016–2021 was 18 per 100.000 inhabitants/year [ 5 ]. IBD specific symptoms are fever, weight and appetite loss, bloody stool, vomiting and anemia [ 6 , 7 ]. A high percentage of other symptoms such as abdominal pain, bloating, diarrhea and watery stools, transversally exhibited in IBD and Irritable Bowel Syndrome (IBS) patients are reported.…”

Section: Introductionmentioning

confidence: 99%

Four-year follow-up of psychiatric and psychosomatic profile in patients with Inflammatory Bowel Disease (IBD)

Gostoli,

Ferrara,

Quintavalle

et al. 2024

BMC Psychol

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Psychological characterization of patients affected by Inflammatory Bowel Disease (IBD) focuses on comorbidity with psychiatric disorders, somatization or alexithymia. Whereas IBD patients had higher risk of stable anxiety and depression for many years after the diagnosis of the disease, there is a lack of studies reporting a comprehensive psychosomatic assessment addressing factors of disease vulnerability, also in the long-term. The objective of this investigation is to fill this gap in the current literature. The aims were thus to assess: a) changes between baseline and a 4-year follow-up in psychiatric diagnoses (SCID), psychosomatic syndromes (DCPR), psychological well-being (PWB-I), lifestyle, gastrointestinal symptoms related to IBD and Irritable Bowel Syndrome (IBS)-like symptoms b) stability of psychiatric and psychosomatic syndromes at 4-year follow-up. A total of 111 IBD outpatients were enrolled; 59.5% of them participated at the follow-up. A comprehensive assessment, including both interviews and self-report questionnaires, was provided at baseline and follow-up. Results showed increased psychiatric diagnoses, physical activity, consumption of vegetables and IBS-like symptoms at follow-up. Additionally, whereas psychiatric diagnoses were no longer present and new psychopathological pictures ensued at follow-up, more than half of the sample maintained psychosomatic syndromes (particularly allostatic overload, type A behavior, demoralization) from baseline to follow-up. Long-term presence/persistence of such psychosocial burden indicates the need for integrating a comprehensive psychosomatic evaluation beyond traditional psychiatric nosography in IBD patients. Moreover, since psychosomatic syndromes represent vulnerability factors of diseases, further studies should target subgroups of patients presenting with persistent psychosomatic syndromes and worse course of the disease.

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Section: Introductionmentioning

confidence: 99%

Four-year follow-up of psychiatric and psychosomatic profile in patients with Inflammatory Bowel Disease (IBD)

Gostoli,

Ferrara,

Quintavalle

et al. 2024

BMC Psychol

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“…Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the intestinal tract that encompasses Crohn’s disease and ulcerative colitis [ 9 ]. Although the etiology of IBD remains unclear, the combined effects of genetic, microbial, immune, and environmental factors appear to trigger an abnormal and excessive immunological response [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although the etiology of IBD remains unclear, the combined effects of genetic, microbial, immune, and environmental factors appear to trigger an abnormal and excessive immunological response [ 10 , 11 ]. IBD is characterized by chronic, relapsing and remitting episodes of inflammation of the gastrointestinal tract caused by an abnormal immune response [ 9 ]. The most widely used mouse model for ulcerative colitis employs dextran sodium sulfate (DSS), because it reproduces some of the key features of human ulcerative colitis (inflammation, diarrhea, and abnormal feces), making it an excellent model for evaluating possible treatments for this disease [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Yerba Mate (Ilex paraguariensis) Reduces Colitis Severity by Promoting Anti-Inflammatory Macrophage Polarization

Olate-Briones,

Albornoz-Muñoz,

Rodríguez-Arriaza

et al. 2024

Nutrients

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Yerba Mate (YM) (Ilex paraguariensis) is a natural herbal supplement with a well-described anti-inflammatory capacity and beneficial effects in different inflammatory contexts such as insulin resistance or obesity. However, whether YM could improve other inflammatory conditions such as colitis or the immune cell population that can be modulated by this plant remains elusive. Here, by using 61 male and female C57BL/6/J wild-type (WT) mice and the dextran sodium sulfate (DSS)-induced acute colitis model, we evaluated the effect of YM on colitis symptoms and macrophage polarization. Our results showed that the oral administration of YM reduces colitis symptoms and improves animal survival. Increasing infiltration of anti-inflammatory M2 macrophage was observed in the colon of the mice treated with YM. Accordingly, YM promoted M2 macrophage differentiation in vivo. However, the direct administration of YM to bone marrow-derived macrophages did not increase anti-inflammatory polarization, suggesting that YM, through an indirect mechanism, is able to skew the M1/M2 ratio. Moreover, YM consumption reduced the Eubacterium rectale/Clostridium coccoides and Enterobacteriaceae groups and increased the Lactobacillus/Lactococcus group in the gut microbiota. In summary, we show that YM promotes an immunosuppressive environment by enhancing anti-inflammatory M2 macrophage differentiation, reducing colitis symptoms, and suggesting that YM consumption may be a good cost-effective treatment for ulcerative colitis.

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Inflammatory Bowel Disease in Pregnancy

Cited by 2 publications

References 94 publications

Four-year follow-up of psychiatric and psychosomatic profile in patients with Inflammatory Bowel Disease (IBD)

Four-year follow-up of psychiatric and psychosomatic profile in patients with Inflammatory Bowel Disease (IBD)

Yerba Mate (Ilex paraguariensis) Reduces Colitis Severity by Promoting Anti-Inflammatory Macrophage Polarization

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